volume 85, issue 4, P431-433 2009
DOI: 10.1038/clpt.2009.1
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Abstract: Understanding the causes and consequences of variability in responses to medicines is a foundation of rational therapeutics. This relies on a detailed understanding of the pharmacokinetic and pharmacodynamic characteristics of medicines and the factors that influence them in patients.1 Ultimately the optimal dose regimen is determined by the pharmacological phenotype of the patient, which is a consequence of the person's genes and the environment in which they are expressed.1 Older people display considerable…

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