Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: A retrospective study

Abstract

Background: Atherosclerosis is associated with chronic inflammation and lipid metabolism. The neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation has been confirmed to be associated with cardiovascular disease prognosis. However, few studies have explored the effects of blood lipid variability on NLR. The aim of this study was to explore the relationship between variability in blood lipid levels and NLR. Methods: The association between variability in blood lipids and NLR was assessed with both univariate and multivariate linear regression. Multivariate linear regression was also performed for a subgroup analysis. Results: The variability of high-density lipoprotein cholesterol (HDL-C) (regression coefficients [β] 4.008, standard error (SE) 0.503, P-value<0.001) and low-density lipoprotein cholesterol (LDL-C) ([β] 0.626, SE 0.164, P-value<0.001) were risk factors for the NLR value, although baseline LDL-C and HDL-C were not risk factors for NLR values. Variability of HDL-C ([β] 4.328, SE 0.578, P-value<0.001) and LDL-C ([β] 0.660, SE 0.183, P-value<0.001) were risk factors for NLR variability. Subgroup analysis demonstrated that the relationship between variability of LDL-C and NLR was consistent with the trend of the total sample for those with diabetes mellitus, controlled blood lipid, statins, atorvastatin. The relationship between the variability of HDL-C and NLR was consistent with the trend of the total sample in all subgroups. Conclusion: The variability of HDL-C and LDL-C are risk factors for the value and variability of NLR, while the relationship between variability of HDL-C and NLR is more stable than the variability of LDL-C in the subgroup analysis, which provides a new perspective for controlling inflammation in patients undergoing PCI.

Blood Neutrophil/Lymphocyte Ratio Is Associated With Cerebral Large-Artery Atherosclerosis but Not With Cerebral Small-Vessel Disease

“…The exact mechanism of these results remains unknown. One explanation is NLR is associated with the variability of cholesterol, rather than baseline cholesterol level ( 49 ). Further study is required to clarify the association between hyperlipidemia and NLR.…”

Variability In Non-HDL-C and Lp(a) Affect The Neutrophil To Lymphocyte Ratio In Patients Undergoing Elective Percutaneous Coronary Intervention

“…In recent years, in addition to the average level of blood lipids, the stability of lipid metabolism has also been considered critical. In our previous studies, it was found that the variation rate of LDL-C is signi cantly related to in ammation [13]. The study of Clark.D et al also found that the variation rate of LDL-C was an important indicator related to the progression of coronary atherosclerosis [23].…”

“…The stability index of lipid level may be another intuitive re ection of the individual's own lipid metabolism level. Our previous study has found that the variation rate of serum LDL-C and HDL-C levels are predictors of in ammation index NLR [13]. However, few studies concern the variability of non-HDL-C and Lp(a).…”

High visit-to-visit cholesterol variability predicts heart failure and adverse cardiovascular events: a population-based cohort study

“…Additionally, some exploratory studies have suggested a possible link between cholesterol variability and inflammation, with HDL-C variability demonstrating particularly strong associations. (25,26) Given that inflammation plays important roles in the pathogenesis of heart failure, (27,28) this is a possible mechanism mediating the observed association between elevated HDL-C variability and elevated risk of heart failure. This was further supported by a recent study by Park et al who observed that both elevated C-reactive protein levels and HDL-C variability were associated with the risk of subclinical left ventricular diastolic dysfunction.…”