Vancomycin syringe study shows significant reduction in dosing variability after introducing a revised protocol

Foinard, Aurélie; Décaudin, Bertrand; Simon, Nicolas; Barthélémy, Christine; Storme, Laurent; Odou, Pascal

doi:10.1111/apa.12484

Cited by 7 publications

(7 citation statements)

References 1 publication

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“…Indeed, different specialties may produce different particulate contamination,26 which is affected by numerous parameters, such as the quality of the active substance, excipients, solvents, conditions, manufacturing processes and clinical preparation practices. An optimised protocol can reduce vancomycin dosage variations and enable homogeneous preparations 27. Indeed, variations in vancomycin dosage were due to the reconstitution solvent (saline solution) and the non-systematic practice of homogeneously mixing the lyophilisate 27…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the stability of vancomycin solutions at concentrations used in clinical services

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Evaluation of the stability of vancomycin solutions at concentrations used in clinical services

et al. 2020

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“…Following a finding in our NICU concerning vancomycin administration, we were able to show great disparities during the preparation of this antibiotic and which were related to the use of the needle [33].…”

Section: Risksmentioning

confidence: 70%

Avoid Drug Incompatibilities: Clinical Context in Neonatal Intensive Care Unit (NICU)

Flamein

Storme

Maiguy-Foinard

et al. 2017

Pharmaceutical Technology in Hospital Pharmacy

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AbstractThe administration of several intravenous products on the same catheter is a very common situation in neonatology, where the stakes are high and the dangers sometimes unknown to clinicians. A large number of factors are involved in this administration, directly related to the installation of the infusion line. Moreover, the therapeutics used are often limited, and excluding classic “Marketing Authorization”. Some of these products may prove to be incompatible and thus lose their effectiveness, or even generate particles that are likely to be administered to the patient. We must be aware of these risks in order to optimize the prescription and administration of these intravenous products, especially as we treat fragile and immature patients. The aim of this work is to review the literature on the subject for the prescribers of neonatology units.

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“…In a neonatal ICU, a piece of research work demonstrated that the dosing variability of vancomycin syringes was mainly due to the solvent used to reconstitute the powder and the non-systematic practice of stirring for complete dissolution of the powder [43]. Reconstitution of IV medications by a centralized intravenous admixture service (CIVAS) ensures the microbiological quality and chemical stability of ready-to-use injectable drugs and thus contributes to the quality and efficient management of the patient in hospital [44,45].…”

Section: Undissolved Solids In Drug Solutionsmentioning

confidence: 99%

Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients

Perez

Maiguy-Foinard

Barthélémy

et al. 2016

Pharmaceutical Technology in Hospital Pharmacy

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AbstractOne of the fundamental principles guiding the pharmaceutical quality of parenteral products is to prevent injecting contaminants from microbiological, chemical or physical sources. It is just as difficult to ensure the absence of chemical and particulate contaminants in injectable products as it is to weigh up the microbiological risk. The problem of particulate matter is mainly related to the preparing and administrating of injectable drugs rather than through the contamination of marketed products. Particulate contamination also arises

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Vancomycin syringe study shows significant reduction in dosing variability after introducing a revised protocol

Cited by 7 publications

References 1 publication

Evaluation of the stability of vancomycin solutions at concentrations used in clinical services

Evaluation of the stability of vancomycin solutions at concentrations used in clinical services

Avoid Drug Incompatibilities: Clinical Context in Neonatal Intensive Care Unit (NICU)

Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients

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