Vanadocene complexes bearing N,N′-chelating ligands: Synthesis, structures and in vitro cytotoxic studies on the A549 lung adenocarcinoma cell line

Melounková, Lucie; Machálková, Aneta; Havelek, Radim; Honzı́ček, Jan; Řezáčová, Martina; Cı́sařová, Ivana; Peterová, E; Vinklárek, Jaromı́r

doi:10.1016/j.jinorgbio.2019.03.015

Cited by 9 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the clinically used drug cisplatin demonstrated only moderate cytotoxicity, which was more than six times lower than the activity of Pt–dpp-Bian analogues. Importantly, complexes 1 , 4 , and 6 showed higher anticancer activity than other metal complexes with Bian ligands, including complexes with V, Co, or Mo metal centers. For example, Mo complexes were completely devoid of cytotoxicity in MDA-MB-231 and moderately cytotoxic in MCF-7, although experimental conditions cannot be directly compared .…”

Section: Resultsmentioning

confidence: 96%

“…As expected, Ar-Bian ligands efficiently intercalated between DNA base pairs; 11 however, their cytotoxicity was only marginal, possibly due to their poor solubility. 34,35 Coordination of Bian derivatives to Ru, 36 Cu, 37 V, 38 Co, 35 or Mo 34 yielded various M(Ar-Bian) complexes with a wide range of anticancer activities. The mechanism of action of M(Ar-Bian) complexes was linked to DNA binding and intercalation, 11 ROS induction, 36 lysosomal dysfunction, 36 interference with the cell cycle, 38 and induction of apoptosis.…”

Section: ■ Introductionmentioning

confidence: 99%

“…34,35 Coordination of Bian derivatives to Ru, 36 Cu, 37 V, 38 Co, 35 or Mo 34 yielded various M(Ar-Bian) complexes with a wide range of anticancer activities. The mechanism of action of M(Ar-Bian) complexes was linked to DNA binding and intercalation, 11 ROS induction, 36 lysosomal dysfunction, 36 interference with the cell cycle, 38 and induction of apoptosis. 36,38 In addition, Cu(Ar-Bian) and Ru(Ar-Bian) complexes demonstrated the ability to reduce tumor growth in vivo.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The mechanism of action of M(Ar-Bian) complexes was linked to DNA binding and intercalation, 11 ROS induction, 36 lysosomal dysfunction, 36 interference with the cell cycle, 38 and induction of apoptosis. 36,38 In addition, Cu(Ar-Bian) and Ru(Ar-Bian) complexes demonstrated the ability to reduce tumor growth in vivo. 33,36 Surprisingly, the anticancer activity of Pt-and Pd(Ar-Bian) complexes has never been investigated.…”

Section: ■ Introductionmentioning

confidence: 99%

“…aeruginosa, comparable to ampicillin and streptomycin. − The biological effects were dependent on the steric bulkiness of Bian substituents and overall lipophilicity of the molecules. , In addition to antimicrobial activity, uncoordinated Ar-Bian ligands and their metal complexes also demonstrated anticancer properties. As expected, Ar-Bian ligands efficiently intercalated between DNA base pairs; however, their cytotoxicity was only marginal, possibly due to their poor solubility. , Coordination of Bian derivatives to Ru, Cu, V, Co, or Mo yielded various M(Ar-Bian) complexes with a wide range of anticancer activities. The mechanism of action of M(Ar-Bian) complexes was linked to DNA binding and intercalation, ROS induction, lysosomal dysfunction, interference with the cell cycle, and induction of apoptosis. , In addition, Cu(Ar-Bian) and Ru(Ar-Bian) complexes demonstrated the ability to reduce tumor growth in vivo . , Surprisingly, the anticancer activity of Pt- and Pd(Ar-Bian) complexes has never been investigated.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism

et al. 2022

View full text Add to dashboard Cite

A series of heteroleptic square-planar Pt and Pd complexes with bis(diisopropylphenyl) iminoacenaphtene (dpp-Bian) and Cl, 1,3-dithia-2-thione-4,5-dithiolate (dmit), or 1,3-dithia-2-thione-4,5-diselenolate (dsit) ligands have been prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis, and cyclic voltammetry (CV). The intermolecular noncovalent interactions in the crystal structures were assessed by density functional theory (DFT) calculations. The anticancer activity of Pd complexes in breast cancer cell lines was limited by their solubility. Pd(dpp-Bian) complexes with dmit and dsit ligands as well as an uncoordinated dpp-Bian ligand were devoid of cytotoxicity, while the [Pd(dpp-Bian)Cl2] complex was cytotoxic. On the contrary, all Pt(dpp-Bian) complexes demonstrated anticancer activity in a low micromolar concentration range, which was 8–20 times higher than the activity of cisplatin, and up to 2.5-fold selectivity toward cancer cells over healthy fibroblasts. The presence of a redox-active dpp-Bian ligand in Pt and Pd complexes resulted in the induction of reactive oxygen species (ROS) in cancer cells. In addition, these complexes were able to intercalate into DNA, indicating the dual mechanism of action.

show abstract

Section: Resultsmentioning

confidence: 96%