Valvulogenesis: Role of Periostin in Cushion Tissue Differentiation

Markwald, Roger R.; Krug, Edward L.; Hoffman, Stan; Rodríguez, Ricardo Moreno; Villavicencio, Laura N.; Mjaatvedt, Corey H.; Conway, Simon J.

doi:10.1002/9780470988664.ch15

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2005

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“…The difference between the isoforms of periostin lies in their temporal and spatial pattern of expression, reflecting possibly different functions for each. Upregulation during development and/or in response to damage and their role in cell adhesion possibly through integrins suggests a function in tissue remodeling (Markwald et al,2005). Modulating their expression and/or interaction with the integrins may lead to therapeutic alternatives during cardiovascular disease and/or oncogenesis.…”

Section: Discussionmentioning

confidence: 99%