Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.03.045 View full text
Xiu-Li Wang, Ying Zhu, Qun Fang

Abstract: In this work, we developed a microfluidic chip-based liquid chromatography (LC) system with valveless gated sample injection method and monolithic columns. The valveless LC system consisted of a microchip with a separation column and a balance column, two syringe pumps and a laser induced fluorescence detector. Nanoliter-scale sample injection was achieved by simply switching the ON and OFF states of the syringe pumps under gated injection mode, without the need of any mechanical valve. The balance column faci…

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