Value of Tumor Size as a Prognostic Variable in Colorectal Cancer

Kornprat, Peter; Pollheimer, Marion J.; Lindtner, Richard A.; Schlemmer, Andrea; Rehak, Peter; Langner, Cord

doi:10.1097/coc.0b013e3181cae8dd

Cited by 105 publications

(90 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These tumors are diagnosed in the early stages with the technological improvement and common use of colonoscopy, but the problem is still going on. Several studies emphasized that larger tumors are more frequent in the right colon (2,20,21). We also found that proximal tumor cancers tended to have a larger diameter.…”

Section: Discussionsupporting

confidence: 65%

“…According to our data, we found that there was a significant statistical relationship between the size of the horizontal diameter and lymph node invasion; large tumors were associated with more positive lymph nodes. Although some studies in the literature support our data (2,19,24), other studies concluded that the size of the horizontal diameter is not an important factor in determining lymph node involvement (18,20,25).…”

Section: Discussioncontrasting

confidence: 47%

“…Li et al (26) found that the diameter of the tumor was smaller than 3 cm in patients with Duke's stage A or B, and it was greater than 3 cm in patients with Duke's stage C or D. Another study demonstrated that tumor size was significantly associated with UICC stage and concluded that increasing tumor diameter was not associated with either depth of invasion or lymph node involvement (2,18). Poritz et al (14) investigated the effect of tumor size on metastatic disease, and it was interesting that tumor volume was smaller in patients with metastatic disease compared to patients without metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are studies that have investigated the relationship between tumor size and survival rate (2,27,28). When overall survival rates and 5-year survival rates are examined, it is generally proposed that large tumors have a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Can horizontal diameter of colorectal tumor help predict prognosis?

Balta

Özdemi̇r

Sücüllü

et al. 2014

UCD

View full text Add to dashboard Cite

Can horizontal diameter of colorectal tumor help predict prognosis? INTRODUCTIONColorectal cancer (CRC) is the third most common cancer among men and women in developed countries (1, 2). The preferred management of non-metastatic colon cancer is removal of the tumor and surrounding lymph nodes. Post-surgical treatment is closely related to the tumor node metastasis (TNM) staging system (3, 4).Depth of tumor penetration (T), regional lymph node involvement (N), and distant metastasis (M) are major parameters predicting the prognosis in CRC patients. The literature data show that tumor staging may be more accurate and the prognosis may be more favorable as the number of harvested lymph nodes increases (5-7).Several studies show that vertical penetration of the tumor on the bowel wall is related to the number of positive lymph nodes and a poorer prognosis. The relationship between horizontal tumor diameter and prognosis is still controversial (8-10). Few studies in gastric and colon cancer indicate that the horizontal extension of the tumor could be an important prognostic factor (2, 11, 12).In this study, we aimed to investigate the relationship between horizontal tumor diameter and prognosis, as well as other well-known prognostic factors of CRC. MATERIAL AND METHODSA total of 486 colorectal cancer patients who were treated in our surgical clinic between 1991 and 2012 were enrolled. Data were obtained from a CRC database and the medical records of the patients. Clinical information and follow-up data were obtained from hospital charts and electronic records. Patients who received neo-adjuvant therapy or underwent palliative resection, had a pathological diagnosis other than adenocarcinoma, and patients with inflammatory bowel disease were excluded (n=47). The remaining 439 patients were included in our retrospective analysis.Adjuvant chemotherapy was given according to the lymph node involvement. Patients with nodenegative tumors did not receive chemotherapy. Patients showing poor prognostic indicators, such as

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Can horizontal diameter of colorectal tumor help predict prognosis?

Balta

Özdemi̇r

Sücüllü

et al. 2014

UCD

View full text Add to dashboard Cite

show abstract

“…However, in our cohort, just the increased tumor size in CRC was closely correlated with the high expression of STYK1/NOK. Although the increased tumor size in CRC was not part of the staging system, previous studies have suggested that tumor size is also an important prognostic factor in CRC (Kornprat et al, 2011). Thus, collectively, STYK1/NOK might be important biological marker in carcinogenesis of CRC and the high expression of STYK1/NOK may contribute to the proliferation of CRC tissues.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Relevance of Overexpressed Serine Threonine Tyrosine Kinase/Novel Oncogene with Kinase Domain (STYK1/NOK) mRNA in Colorectal Cancer

Orang

Safaralizadeh

Feizi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Association of tumor size in pathological T4 colorectal cancer with desmoplastic reaction and prognosis

Shiraishi

Ogawa

Katayama

et al. 2022

Annals of Gastroent Surgery

View full text Add to dashboard Cite

Background Tumor size in pathological T4 (pT4) colorectal cancer (CRC) is associated with oncological prognosis; however, its relation to epithelial‐mesenchymal transition (EMT)‐associated histology is unclear. We aimed to investigate the association of tumor size with oncological prognosis and EMT. Methods We performed a retrospective analysis of 95 patients with primary CRC who underwent radical surgery and were consecutively diagnosed with pT4. Results Both 3‐y disease‐free survival (DFS) and cancer‐specific survival (CSS) were significantly higher in patients with tumor size ≥50 mm than in those with tumor size <50 mm (P = .009 and P = .011, respectively). The independent factors identified in the multivariate analysis for DFS were pathological lymph node metastasis (hazard ratio [HR], 2.551; 95% confidence interval [CI], 1.031–6.315; P = .043), distant metastasis (HR, 2.511; 95% CI, 1.140–5.532; P = .022), tumor size (HR, 0.462; 95% CI, 0.234–0.913; P = .026), and adjuvant chemotherapy (HR, 0.357; 95% CI, 0.166–0.766; P = .008). The independent factors identified in multivariate analysis for CSS were tumor location (HR, 10.867; 95% CI, 2.539–45.518; P = .001) and tumor size (HR, 0.067; 95% CI, 0.014–0.321; P < .001). In pT4 CRC, smaller tumor size was associated with nonmature desmoplastic reaction and EMT‐related histology. Conclusions Tumor size ≥50 mm was associated with a better DFS and CSS than that of <50 mm, in patients with pT4 CRC. Smaller tumor size with advanced invasion likely reflects a more biologically aggressive phenotype in pT4 CRC.

show abstract

Value of Tumor Size as a Prognostic Variable in Colorectal Cancer

Abstract: Tumor size proved to be an independent prognostic parameter for patients with colorectal cancer. Optimal cut-off values vary among different parts of the large bowel. Whereas prognostic significance is strong within the colon, it appears to be of minor value within the rectum.

Cited by 105 publications

References 25 publications

Can horizontal diameter of colorectal tumor help predict prognosis?

Can horizontal diameter of colorectal tumor help predict prognosis?

Diagnostic Relevance of Overexpressed Serine Threonine Tyrosine Kinase/Novel Oncogene with Kinase Domain (STYK1/NOK) mRNA in Colorectal Cancer

Association of tumor size in pathological T4 colorectal cancer with desmoplastic reaction and prognosis

Contact Info

Product

Resources

About