Value of repeat ultrasound-guided fine-needle aspiration in thyroid nodule with a first benign cytologic result: Impact of ultrasound to predict malignancy

Maia, Frederico Fernandes Ribeiro; Matos, Patrícia Francisca de; Pavin, Elizabeth João; Vassallo, José; Zantut-Wittmann, Denise Engelbrecht

doi:10.1007/s12020-011-9467-0

Cited by 22 publications

(8 citation statements)

References 27 publications

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“…Interestingly, a very high cancer rate (32 %) was found. This finding was perfectly in agreement with that previous reported by papers analyzing the likelihood for malignancy in these specific nodules [46][47][48]. More recently, CNB or conventional FNAC was proposed to patients with newly discovered at risk thyroid lesions [24]; the diagnostic accuracy of CNB was significantly higher than that of FNAC [24].…”

Section: Use Of Cnb In Thyroid Neoplasms (Thy 3/class 3/category Iii-supporting

confidence: 91%

Thyroid core needle biopsy: taking stock of the situation

Trimboli

Crescenzi²

2014

Endocrine

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Recently, the microhistologic evaluation by core needle biopsy (CNB) has been reported as high accurate to diagnose thyroid nodules with previous indeterminate or not adequate fine-needle aspiration cytology. In addition, sparse data have been reported regarding the use of CNB in other conditions. Aim of this review was to furnish the state of the art of this topic by summarizing published data about the diagnostic performance of CNB in thyroid lesions, and provide an easy to use reference for clinical practice. Sources encompass studies published through May 2014. Original articles were investigated and following specific aspects were discussed: 1. The "large" needle biopsy in 90's; 2. Complications by and patient's comfort with thyroid CNB; 3. Advantages provided by examination of a microhistologic sample of thyroid nodule; 4. Use of CNB in thyroid nodules with previous not adequate (Thy 1/Class 1/Category I) cytology; 5. Use of CNB in thyroid neoplasms (Thy 3/Class 3/Category III-IV) cytology; 6. Use of CNB in specific ultrasonographic presentations of thyroid nodules or in patients with peculiar clinical contexts; 7. First-line approach by CNB in thyroid nodules; 8. Immunohistochemistry and molecular tests on CNB samples; and 9. Future perspective.

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Section: Use Of Cnb In Thyroid Neoplasms (Thy 3/class 3/category Iii-supporting

confidence: 91%

Thyroid core needle biopsy: taking stock of the situation

Trimboli

Crescenzi²

2014

Endocrine

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“…We confirmed that in both examined groups malignant lesions showed at least 2 malignancy risk features more often than benign lesions. It is concordant with observations by Gul et al 2010 that the presence of CT seems to have no effect on the US characteristics of malignant nodules [33] as well as the other observations indicating that it is rational to perform repeat FNA of ultrasonographically suspected lesions [12, 34–36]. …”

Section: Discussionsupporting

confidence: 91%

Repeat FNA Significantly Lowers Number of False Negative Results in Patients with Benign Nodular Thyroid Disease and Features of Chronic Thyroiditis

Słowińska-Klencka

Woźniak-Oseła

Popowicz

et al. 2014

International Journal of Endocrinology

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Purpose. The aim of the study was to compare the risk of thyroid malignancy and efficacy of repeat FNA in patients with thyroid nodules diagnosed cytologically as benign lesion (BL) with features of chronic thyroiditis (BL-CT) and BL without CT features (BL-nCT). Methods. The analysis included 917 patients with BL-CT and 7046 with BL-nCT in the first FNA. Repeat biopsy was carried out in 787 patients of BL-CT and 5147 of BL-nCT; 218 patients of BL-CT and 2462 of BL-nCT were operated; in 88 cases of BL-CT and 563 of BL-nCT both ways of follow-up were available. Results. Outcome of repeat cytology implied surgery more frequently in patients with BL-CT than with BL-nCT—3.2% versus 1.9%, P < 0.05. Incidence of cancer (including incidentalomas) was higher in patients with BL-CT operated after one benign cytology than in patients with two benign FNA outcomes: 10.8% versus 1.6%, P < 0.05. In patients with BL-nCT that difference was not significant: 3.2% versus 2.6%. Conclusions. Patients with thyroid nodules diagnosed as BL with CT features have higher risk of malignancy than patients with BL without CT features. Repeat biopsy significantly lowers percentage of FN results in patients with BL-CT in the first FNA.

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“…Investigations into selecting repeat FNA as a management approach for thyroid nodules with benign cytology using US features have been done and reported on in a few institutions [13], [28], [34], [35]. Therefore, we investigated the management algorithm for thyroid nodules with benign cytology using US features from data collected from multiple institutions.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Nodule with Benign Cytology: Is Clinical Follow-Up Enough?

et al. 2013

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ObjectiveIn this multicenter study, we investigated the management algorithm for thyroid nodules with benign cytology using US features from data collected from 7 institutions.Materials and MethodsThe institutional review board approved this retrospective study. Data on 700 focal thyroid nodules in 673 consecutive patients were collected from 7 university-affiliated hospitals. This study included nodules that were diagnosed as benign at initial cytologic evaluation and that underwent pathologic or follow-up study. The risk of malignancy was compared according to the US assessments of each institution as well as looking at all the nodules together as a whole.ResultsOf the 700 nodules, 688 (98.3%) were benign and 12 (1.7%) were malignant. If initial cytologic results were benign, the likelihood of the nodule actually being malignant was from 1 to 3%, varying by institution. The likelihood of a cytologically benign nodule with positive US being malignant (4.7%, 8/169) was higher than that of one without positive US (0.8%, 4/531) (P = .002).ConclusionBased on our multicenter study, repeat FNA should be performed in thyroid nodules with initial benign cytology showing suspicious US features in order to decrease the number of false negative cases.

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Value of repeat ultrasound-guided fine-needle aspiration in thyroid nodule with a first benign cytologic result: Impact of ultrasound to predict malignancy

Cited by 22 publications

References 27 publications

Thyroid core needle biopsy: taking stock of the situation

Thyroid core needle biopsy: taking stock of the situation

Repeat FNA Significantly Lowers Number of False Negative Results in Patients with Benign Nodular Thyroid Disease and Features of Chronic Thyroiditis

Thyroid Nodule with Benign Cytology: Is Clinical Follow-Up Enough?

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