Value of PET/CT in the Management of Liver Metastases, Part 1

Sacks, Ari; Peller, Patrick J.; Surasi, Devaki Shilpa; Chatburn, Luke; Mercier, Gustavo; Subramaniam, Rathan M.

doi:10.2214/ajr.10.6331

Cited by 76 publications

(37 citation statements)

References 22 publications

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“…On the other hand, diffusion-weighted MR imaging would be helpful for differentiating such lesions; metastatic tumors are expected to have high signals, and our patient showed no elevated signals, atypically for metastatic tumors (14). Positron emission tomography -CT would be useful (16), but the patient unfortunately did not have the opportunity to undergo this imaging modality. When there are any aspects that are not typical of metastatic tumors on images, a preoperative needle biopsy or intraoperative frozen section could be obtained, to avoid excessive therapy.…”

mentioning

confidence: 74%

Oxaliplatin-induced Liver Injury Mimicking Metastatic Tumor on Images: A Case Report

Uchino¹,

Fujisawa²,

Watanabe³

et al. 2013

Japanese Journal of Clinical Oncology

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Oxaliplatin-based chemotherapy is widely used for advanced colorectal cancer treatment, but it occasionally induces liver injury that is characterized histologically by sinusoidal dilatation, hepatic plate atrophy and/or venular obstruction. Most of the patients do not reveal apparent radiological abnormalities, however. Here, we report the case of a 47-year-old man with a radiologically detectable mass-forming oxaliplatin-induced sinusoidal injury that mimicked multiple liver tumors. These mass lesions were found on computed tomography images after the administration of six cycles of folinic acid, fluorouracil and oxaliplatin therapy as adjuvant chemotherapy for Stage III rectal cancer. The patient had to undergo liver resection because imaging studies could not exclude metastases. The histological examination revealed that a resected mass lesion was composed of severe sinusoidal dilatation. Milder dilatation was also seen in the surrounding parenchyma. We diagnosed the patient as having an oxaliplatininduced sinusoidal injury with severe deviation. As oxaliplatin is a standard agent in colorectal cancer therapy today, all clinicians and pathologists should be aware of such nonneoplastic lesions as one of the rare differential diagnoses of metastatic liver tumor, to prevent overtreatment.

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confidence: 74%

Oxaliplatin-induced Liver Injury Mimicking Metastatic Tumor on Images: A Case Report

Uchino¹,

Fujisawa²,

Watanabe³

et al. 2013

Japanese Journal of Clinical Oncology

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“…Sacks described a combined sensitivity of 88% and specificity of 96% for hepatic disease. Despite this high specificity this case highlights the importance of differential diagnoses [1]. However; this case demonstrates that benign gallstone abscesses can be misrepresented as metastatic cancer.…”

Section: Discussionmentioning

confidence: 82%

Spilled Gallstone Abscesses Mimicking Liver Metastases

Matthews¹

2016

JOJCS

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“…Liver metastases are 18 -40 times more common than a primary liver malignancy [2]. PET CT is considered useful in systemic therapy assessment and surveillance for liver metastases [3]. "Hepatic superscan" is an uncommon PET-CT finding.…”

Section: Discussionmentioning

confidence: 99%