Value of NT-ProBNP Level and Echocardiographic Parameters in ST-Segment Elevation Myocardial Infarction Treated by Primary Angioplasty: Relationships Between These Variables and Their Usefulness as Predictors of Ventricular Remodeling

Haldon, José López; Quero, Mónica Fernández; Mancha, Fernando; Urbano, José A.; Guisado, Agustín; Villa, Manuel; Valle, Juan Ignacio Soto; Puras, María José Rodríguez; Ballesteros, Sara; Pardo, F. López; Llera, Luis Díaz de la; González, A.; Martı́nez, Ángel

doi:10.1016/s1885-5857(10)70205-x

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Also, there was non-significant difference between both groups regarding the risk factors of coronary artery disease like hypertension (P 0.86), diabetes mellitus (P 0.065), dyslipidemia (P 0.22) and family history (P= 0.087). This agrees with López Haldón et al (21) who found no significant difference between both groups regarding cardiac risk factors. But On the other hand, there was significant difference regarding smoking (P=0.012), in favor of Group II (Patients with LV Remodeling) (21) .…”

Section: Discussionsupporting

confidence: 92%

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Predictors of Contractile Recovery After Successful Primary Percutaneous Coronary Intervention

Awady¹,

Roshdy²,

Mohammad³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Accurate diagnosis, characterization, and quantification of myocardial infarction (MI) are essential to assess the impact of therapy and to aid in predicting prognosis of patients with ischaemic heart disease.Objective: This study aimed to define different parameters regarding prediction of myocardial functional recovery following successful reperfusion of acute ST segment elevation myocardial infarction (STEMI). Patients and methods: This prospective study was carried out in Zagazig University and National Heart Institute (NHI) of Egypt during the period from June 2020 to June 2021. The study included 48 patients admitted with first acute STEMI. All patients were subjected to demographic data taking, electrocardiography and echocardiography examination (two examinations were done, the first was immediately after reperfusion and the second was 3 months from primary percutaneous coronary intervention (PCI). Results: There was no statistically significant difference between demographic data and risk factors except smoking habit. Regarding laboratory findings there were significant lower troponin value, peak CKMB value compared to patients had remolding (p=0.0001, p=0.027 respectively). Regarding ECG parameters, there was no statistical significant difference between the study groups regarding sum ST elevation and MI territory (p value > 0.05), but there was highly statistically significant difference between the study groups regarding 90 min ST resolution among contractile recovery (group I) p=0.0001. Conclusions: In this study patients affected by AMI with ST segment elevation and treated by primary PCI showed contractile recovery in 60.4% of the patients, while the remodeling of the LV has been observed in 39.6%.

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Section: Discussionsupporting

confidence: 92%

“…This agrees with López Haldón et al (21) who found no significant difference between both groups regarding cardiac risk factors. But On the other hand, there was significant difference regarding smoking (P=0.012), in favor of Group II (Patients with LV Remodeling) (21) .…”

Section: Discussionsupporting

confidence: 92%

Predictors of Contractile Recovery After Successful Primary Percutaneous Coronary Intervention

Awady¹,

Roshdy²,

Mohammad³

et al. 2022

The Egyptian Journal of Hospital Medicine

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“…We found that NT-proBNP was an independent predictive factor for LV remodeling in all the four models in our study. Comparable results have also been found in previous work (50,51). These studies illustrate the importance of specific cardiac biochemical biomarkers in predicting STEMI LV remodeling, including troponin T, CK-MB, and NT-proBNP.…”

Section: Discussionsupporting

confidence: 86%

Circulating miR-1 as a potential predictor of left ventricular remodeling following acute ST-segment myocardial infarction using cardiac magnetic resonance

Ma¹,

Ma²,

Wang³

et al. 2020

Quant Imaging Med Surg

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Background: The identification of patients with a high likelihood of left ventricular (LV) remodeling with a high-risk prognosis has critical implications for risk stratification after acute ST-segment elevation myocardial infarction (STEMI). This study aimed to evaluate the relationship between circulating miR-1 and 6-month post-infarct LV remodeling based on cardiac magnetic resonance (CMR) imaging.Methods: A total of 80 patients with a first STEMI treated with primary percutaneous coronary intervention (PCI) who underwent CMR imaging 1 week and 6 months after STEMI were evaluated. The percentage changes of LV ejection fraction (LVEF), LV end-diastolic volume (LVEDV), LV end-systolic volume index (LVESV) at 1 week and 6 months after PCI (%ΔLVEF, %ΔLVEDV and %ΔLVESV) were calculated. miR-1 was measured using polymerase chain reaction (PCR)-based technologies in plasma samples that were collected at admission. The study group was divided into two groups based on a 10% cutoff value for the percentage of change in the LV end-diastolic volume (%ΔLVEDV): remodeling at high risk of major adverse cardiac events (MACEs) (%ΔLVEDV ≥10%, termed the LV remodeling group) and remodeling at lower risk of MACEs (%ΔLVEDV <10%, termed the non-LV remodeling group). The associations of miR-1 expression with the %ΔLVEDV, percentage change in the LV end-systolic volume (%ΔLVESV), and percentage change in the LV ejection fraction at follow-up were estimated.Results: Twenty-two patients (27.5%) showed adverse LV remodeling, and 58 patients (72.5%) did not show adverse LV remodeling at the 6-month follow-up of CMR. The mean LVEF, LVEDV index, and LVESV index values at 1 week were 50.6%±8.2%, 74.6±12.8 mL/m 2 , and 37.2±10.2 mL/m 2 , respectively.Mean LVEF at follow-up (53.5%±10.6%) was increased compared with baseline (P<0.001). There were significant decreases in LVEDV index and LVESV index values at follow-up (72.0±14.9 mL/m 2 and 33.7±11.0 mL/m 2 , respectively; P=0.009 and P<0.001, respectively). The expression of miR-1 at admission was positively correlated with the %ΔLVEDV (r=0.611, P<0.001) and %ΔLVESV (r=0.268, P=0.016).Receiver operating characteristic (ROC) analysis showed that miR-1 expression predicted LV remodeling with an area under the curve (AUC) value of 0.68 (95% CI: 0.56-0.78). Compared with the clinical factors of peak creatine kinase-myocardial band (CK-MB) and peak troponin T level, peak logNT-proBNP showed the highest predictive power, with an AUC value of 0.75 (95% CI: 0.64-0.84). A model including the clinical, CMR, and miR-1 factors showed greater predictive power (P=0.034) than a model including only clinical and CMR factors, with AUCs of 0.89 (95% CI: 0.80-0.95) and 0.81 (95% CI: 0.71-0.89), respectively.Conclusions: Circulating miR-1 at admission is an independent predictor of LV remodeling 6 months after STEMI. miR-1 showed incremental value in predicting LV remodeling compared with the clinical and CMR measurements.

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“…Other studied early parameters of myocardial dysfunction included post-MI LVEDP, 31 LAVI, diastolic dysfunction stage, and E/E′ ratio. 32 Only diastolic dysfunction >stage I was shown to be associated with higher serum galectin-3 levels. However, this was not supported with other parameters of diastolic dysfunction such as E/E′ ratio or LVEDP.…”

Section: Discussionmentioning

confidence: 94%

The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study

et al. 2018

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Introduction:Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking galectin-3 expression would have an impact on the heart and that its relationship to remodeling is not simply an epiphenomenon. The direct association between galectin-3 and myocardial inflammation, dysfunction, and adverse cardiovascular outcomes post-MI was examined using clinical and translational studies.Methods:We performed expression analysis of 9753 genes in murine model of acute MI. For galectin-3 loss of function studies, homozygous galectin-3 knock-out (KO) mice were subjected to coronary artery ligation procedure to induce acute MI (MI, N = 6; Sham, N = 6). For clinical validation, serum galectin-3 levels were measured in 96 patients with ST-elevation MI. Echocardiographic and angiographic parameters of myocardial dysfunction and 3-month composite outcome including mortality, recurrent MI, stroke, and heart failure hospitalization were measured.Results:In the infarct regions of murine models, galectin-3 was a robustly expressed gene. Elevated galectin-3 expression strongly correlated with macrophage-mediated genes. Galectin-3 KO mice showed reduced myocardial macrophage infiltration after acute MI. Galectin-3 levels were higher in patients with early systolic dysfunction, and predicted 3-month major adverse cardiovascular events (area under the curve [AUC]: 0.917 ± 0.063; P = .001).Conclusions:Galectin-3 is directly associated with early myocardial inflammation post-MI and may represent a potential target for therapeutic inhibition.

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Value of NT-ProBNP Level and Echocardiographic Parameters in ST-Segment Elevation Myocardial Infarction Treated by Primary Angioplasty: Relationships Between These Variables and Their Usefulness as Predictors of Ventricular Remodeling

Cited by 3 publications

References 29 publications

Predictors of Contractile Recovery After Successful Primary Percutaneous Coronary Intervention

Predictors of Contractile Recovery After Successful Primary Percutaneous Coronary Intervention

Circulating miR-1 as a potential predictor of left ventricular remodeling following acute ST-segment myocardial infarction using cardiac magnetic resonance

The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study

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