volume 28, issue 2, P323-336 2012
DOI: 10.3233/jad-2011-110761
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Claire Boutoleau-Bretonnière, Thibaud Lebouvier, Odile Delaroche, Estelle Lamy, Christelle Evrard, Tiphaine Charriau, Cédric Bretonnière, Philippe Damier, Pascal Derkinderen, Martine Vercelletto

Abstract: The objective of this study was to examine the diagnostic accuracy of imaging and CSF biomarkers in clinically ambiguous dementia (CAD). 69 patients were prospectively followed. The endpoint was clinical diagnosis at follow-up of 24 months based upon existing criteria. Medial temporal lobe atrophy score on MRI, distinctive patterns on 99 mTc-HMPAO-SPECT, and CSF levels of amyloid-β peptide, total tau protein, and P-tau181P were used together with neuropsychological testing to assess Se (sensitivity) and Sp (sp…

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