Value of imprint cytology for ultrasound-guided transthoracic core biopsy

Liao, Wen-Chieh

doi:10.1183/09031936.04.00030404

Cited by 22 publications

(20 citation statements)

References 19 publications

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“…These values are comparable to some of the studies in the literature and are even better than some (table 5) [6,7,8,9,10,11,12,13,14,15,16]. It should be pointed out here that biopsy diagnosis is attained after immunohistochemistry which was not possible on cytology.…”

Section: Discussionsupporting

confidence: 70%

“…Our data clearly show that the results of ROSAC obtained by the cytotechnologist are equivalent to or better than most of the studies in the literature [9,10,12,13], besides being very cost-effective.…”

Section: Discussionmentioning

confidence: 49%

“…In most of the studies, imprint cytology is used as a technique for on-site adequacy checking with an adequacy rate in the range of 94-98% (table 5) [6,7,8,9,10,11,12,13,14,15,16]. …”

Section: Discussionmentioning

confidence: 99%

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The Role of Squash Cytology in Rapid On-Site Adequacy Checking and Rapid Diagnosis in Image-Guided Gun Biopsy at a Tertiary Cancer Center

Kane¹,

Prabhudesai²,

Ojha³

et al. 2013

Acta Cytologica

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Objective: To evaluate the role of squash cytology in rapid on-site adequacy checking (ROSAC) of image-guided gun biopsy and to determine its diagnostic accuracy at a tertiary cancer center. Study Design: This was a prospective study on 183 patients undergoing image-guided biopsy. Squash smears were prepared from biopsy cores and checked for adequacy by cytotechnologists. When adequate, more cores were sampled from the same area for histopathology. If inadequate, the procedure was repeated at the same sitting on a different area. The squash smears were reported by cytopathologists within 4 h after staining with conventional Papanicoloau stain. The results were compared with the final histopathology report. Results: The sampling was representative in 95.6% cases with concordance for adequacy in 97.3% cases. The sensitivity, specificity, positive predictive value and negative predictive value of squash cytology for diagnosis of the lesion were 99.4, 92.7, 97.7 and 97.4%, respectively. Conclusions: Squash cytology is an ideal and cost-effective technique for ROSAC of image-guided biopsies, which ensures adequacy, avoids repeat procedures and prevents delay in diagnosis. It can be effectively performed by trained cytotechnologists in radiology clinics. Squash cytology is also a cost-effective tool offering rapid diagnosis which expedites planning of treatment.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 49%

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The Role of Squash Cytology in Rapid On-Site Adequacy Checking and Rapid Diagnosis in Image-Guided Gun Biopsy at a Tertiary Cancer Center

Kane¹,

Prabhudesai²,

Ojha³

et al. 2013

Acta Cytologica

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“…Recently, PAULOSE et al [13] showed that imprint cytology could assist rapid diagnosis of lung cancer metastasis in mediastinal lymph nodes following CT-guided TNB. LIAO et al [14] demonstrated improved diagnostic accuracy by using imprint cytology following ultrasound (US)-guided TNB of peripheral lung lesions. The role of touch imprint cytology in CT-guided coaxial core biopsy of intrathoracic lesions has not been investigated.…”

mentioning

confidence: 99%

Imprint cytology improves accuracy of computed tomography-guided percutaneous transthoracic needle biopsy

Chang

Yu²,

Lee³

et al. 2008

European Respiratory Journal

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The aim of the present study was to investigate whether imprint cytology can improve the diagnostic accuracy of computed tomography-guided transthoracic core biopsy.Between October 1997 and June 2004, thoracic lesions in 622 patients underwent biopsy using 19-gauge coaxial guiding needles and 20-gauge biopsy needles under computed tomography guidance. Touch imprint cytology and histopathology were performed for all biopsy specimens.Of these lesions, 431 (74.1%) were diagnosed as malignant, 151 (25.9%) as benign and 40 (6%) as nondiagnostic. Imprint cytology plus histology shows an improved diagnostic accuracy of 96.4% compared with that of imprint cytology alone (92.3%) or histopathology alone (93.0%). Procedure-related complications requiring further treatment occurred in eight (1.4%) patients.In conclusion, imprint cytology combined with histopathology can improve the diagnostic accuracy of computed tomography-guided transthoracic needle biopsy.KEYWORDS: Computed tomography, cytology, diagnostic accuracy, needle lung biopsy P ercutaneous transthoracic needle biopsy (TNB) is an important diagnostic tool in the management of lung and mediastinal lesions [1][2][3][4][5]. Fine-needle aspiration (FNA) with computed tomography (CT) guidance has an accuracy and sensitivity of 76-95% for the detection of malignancy in solitary lung nodules [3][4][5]. Automated biopsy needles can acquire more core specimens and increase the diagnostic sensitivity to 84-96% [6,7]. Coaxially guided needle biopsy minimises the risk associated with repeated pleural penetration and increases the volume of tissue retrieved compared with aspiration cytology or single-shot core biopsy. The diagnostic sensitivity for malignancy is 77-96% and the specificity for benign disease is 91-94% with automated coaxial core biopsy [1,2,8].Efforts to increase the diagnostic accuracy of image-guided TNB include frozen-section pathology [9] or FNA cytology combined with core biopsy under CT fluoroscopic guidance [10]. Touch imprint cytology is useful for diagnosing metastasis in surgically removed lymph nodes in breast cancer and better than conventional haematoxylin-eosin staining of paraffin sections [11,12]. However, data regarding imprint cytology and TNB are very limited. Recently, PAULOSE et al. [13] showed that imprint cytology could assist rapid diagnosis of lung cancer metastasis in mediastinal lymph nodes following CT-guided TNB. LIAO et al. [14] demonstrated improved diagnostic accuracy by using imprint cytology following ultrasound (US)-guided TNB of peripheral lung lesions. The role of touch imprint cytology in CT-guided coaxial core biopsy of intrathoracic lesions has not been investigated. The objective of the present study was to evaluate whether touch imprint cytology as an adjunct to CT-guided coaxial core biopsy can improve diagnostic accuracy for thoracic lesions. METHODS AND MATERIALS Study subjectsTissue specimens from 622 patients who underwent CT-guided TNB of thoracic lesions between October 1997 and June 2004 at the Natio...

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“…Touch imprint cytology (TIC) offers sensitivity and specifi city that is equivalent to that of frozen sections. TIC preserves the original sample for permanent fi xation and avoids potential sample loss, which is virtually impossible with frozen sectioning (Creager et al 2002, Khana et al 1988, Hahn et al 1995, Liao et al 2004, Suen et al 1976, Brogi et al 2005.…”

mentioning

confidence: 99%

Touch imprint cytology: a rapid diagnostic tool for oral squamous cell carcinoma

Geetha

Astekar²,

Ashok

et al. 2015

Biotechnic & Histochemistry

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Techniques for intraoperative pathologic examination of oral squamous cell carcinoma are rare in the literature. We evaluated the advantages and limitations of touch imprint cytology for intraoperative diagnosis of oral squamous cell carcinoma. We used 30 incisional biopsies of clinically diagnosed oral squamous cell carcinoma and compared touch imprint cytology to histopathological sections. Touch imprint cytology showed 24 specimens positive for malignancy, two suspicious for malignancy and four inadequate specimens. The accuracy of the test was 93.2%. Touch imprint cytology is an accurate, simple, rapid and cost-effective method that aids diagnosis of oral squamous cell carcinoma during operation, but it does not replace incisional biopsy.

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Value of imprint cytology for ultrasound-guided transthoracic core biopsy

Cited by 22 publications

References 19 publications

The Role of Squash Cytology in Rapid On-Site Adequacy Checking and Rapid Diagnosis in Image-Guided Gun Biopsy at a Tertiary Cancer Center

The Role of Squash Cytology in Rapid On-Site Adequacy Checking and Rapid Diagnosis in Image-Guided Gun Biopsy at a Tertiary Cancer Center

Imprint cytology improves accuracy of computed tomography-guided percutaneous transthoracic needle biopsy

Touch imprint cytology: a rapid diagnostic tool for oral squamous cell carcinoma

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