Value of homocysteine levels, troponin I, and score for neonatal acute physiology and perinatal extension II as early predictors of morbidity

Usluer, Hale; Turker, Gülcan; Gökalp, Ayşe Sevim

doi:10.1111/j.1442-200x.2011.03485.x

Cited by 2 publications

(2 citation statements)

References 27 publications

(37 reference statements)

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“…The results suggest that significant elevation of cord troponin is an excellent early predictor of severity of hypoxic-ischaemic encephalopathy and mortality in term infants [48]. Umbilical cord troponin I was not different between hospitalized newborns versus non-hospitalized newborns in a study by Usluer et al [40].…”

Section: Cardiac Injury Biomarkers In the Cord Bloodmentioning

confidence: 95%

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Cardiac injury biomarkers in paediatric age: Are we there yet?

et al. 2016

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The aim of this article is to evaluate the clinical utility of cardiac injury biomarkers in paediatric age. In December 2015, a literature search was performed (PubMed access to MEDLINE citations; http://www.ncbi.nlm.nih.gov/PubMed/ ). The search strategy included the following medical subject headings and text terms for the key words: "cardiac injury biomarkers", "creatine kinase-MB", "myoglobin", "troponin", "children", "neonate/s", "newborn/s", "infant/s" and echocardiography. In the paediatric population, troponins show a good correlation with the extent of myocardial damage following cardiac surgery and cardiotoxic medication and can be used as predictors of subsequent cardiac recovery and mortality. Elevation of cardiac injury biomarkers may also have diagnostic value in cases when cardiac contusion or pericarditis is suspected. Cardiac injury biomarkers are very sensitive markers for the detection of myocardial injury and have been studied in healthy newborns, after tocolysis, intrauterine growth restriction, respiratory distress and asphyxia. The proportion of newborns with elevated troponin was higher than that in ill infants, children, and adolescents and in healthy adults, suggesting that myocardial injury, although clinically occult, is common in this young age group. Results suggest that significant elevation of cord troponin is an excellent early predictor of severity of hypoxic-ischaemic encephalopathy and mortality in term infants. Cardiac biomarkers may also benefit centres without on-site echocardiography with evidence showing good correlation with echo-derived markers of myocardial function. Further studies are needed to better clarify the role of cardiac biomarkers in paediatric age and their correlation with echocardiographic parameters.

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Section: Cardiac Injury Biomarkers In the Cord Bloodmentioning

confidence: 95%

“…Despite that, very little is known about its role in newborns [40]. Lipshultz et al evaluated the frequency of elevations in markers of myocardial injury in the umbilical cord and neonatal serum samples from 32 otherwise healthy newborns.…”

Section: Cardiac Injury Biomarkers In Newbornsmentioning

confidence: 98%