“…Some of the most recent guidelines, such as the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) 2020 ones, have incorporated a no-biopsy approach as the first pathway for diagnosing CD in children, which allows the direct confirmation of CD in children whose anti-tTG-IgA titers are more than 10 times (10×) the upper limit of normal (ULN) and anti-endomysial antibodies (anti-EMA) are positive [14,15]. Using this approach, 50-75% of patients can be diagnosed without further tests, resulting in a decrease in costs, risks, and refusals of diagnosis [14,16,17]. However, it is important to be aware Nutrients 2023, 15, 4926 2 of 13 that to avoid false-negative results complementary tests must be performed, and those who are tested need to maintain a gluten-containing diet to achieve active CD [1,2,18].…”