Value Analysis of Neoadjuvant Radiotherapy for Breast Cancer after Modified Radical Mastectomy Based on Data Mining

Abstract

Over the last two generations, there has been a surge of interest in nonmutilating treatment for women with early breast cancer. Neoadjuvant radiation therapy, which is progressively being provided to breast cancer patients, could be used to decrease tumor burden while also providing an ability to examine treatment response. This paper aims to explore the effects of the initiation time of radiotherapy after modified adjuvant radical mastectomy on the prognosis of breast cancer. The EMR data can be used to mine hidden rules, which are of great significance for treatment and prognosis analysis. In collaboration with breast cancer, the appropriate prediction model and visualization method are selected and a visual analysis system for breast cancer group and treatment plan based on electronic medical record is constructed. Patients with multiple dimensions are reduced and clustered to form patient groups. The differences of characteristics among patient groups are intuitively displayed by using Nightingale diagram, word cloud, and time axis visualization methods. The support vector machine (SVM) model is used to predict the treatment scheme. The radiotherapy time after modified radical surgery in the two groups was within 15 weeks (observation group) and 15 weeks (routine group), respectively. The incidence of complications, local recurrence rate, progression-free survival, and quality of life scores of patients in the routine group and observation group were compared. The total incidence of complications differed significantly between the observation and routine groups. The physical function, material function, psychological function, and social function of the observation group were significantly higher than the routine group P < 0.05 . Radiotherapy within 15 weeks after modified radical mastectomy for breast cancer can not only reduce the local recurrence rate but also prolong the progression-free survival of patients, and the incidence of complications will not increase, which will greatly help improve the quality of life of patients.

CT-guided iodine-125 brachytherapy as salvage therapy for local-regional recurrent breast cancer

“…In China, the latest data from the National Cancer Center demonstrate that its morbidity ranks the fifth (2). To date, external beam radiotherapy (EBRT), which could reduce the local recurrence rate and prolong the progression-free survival (PFS) of BC patients, has become the standard treatment after modified radical mastectomy and Breast-Sparing Surgery (3,4). Unfortunately, approximately 5-30% of patients with BC who underwent surgical resection, chemoradiotherapy, endocrine, and/ or target therapy presented with local recurrence (5,6).…”

Radiotherapy dosimetry and radiotherapy related complications of immediate implant-based reconstruction after breast cancer surgery

“…Postmastectomy radiation therapy (PMRT) can both reduce the risk of local recurrence and improve the survival rate of patients with high risk factors, such as the maximum diameter of the primary tumor ≥5 cm and positive axillary lymph nodes (13)(14)(15). However, the impact of implant-based breast reconstruction (IBBR) on the delivery of PMRT remains controversial.…”

Retracted: Value Analysis of Neoadjuvant Radiotherapy for Breast Cancer after Modified Radical Mastectomy Based on Data Mining

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”