Valproate: It's effects on hair

Kakunje, Anil; Prabhu, Ashwini; Priya, ES Sindhu; Karkal, Ravichandra; Kumar, Parmod; Gupta, Nitin; Rahyanath, P. K.

doi:10.4103/ijt.ijt_10_18

Cited by 13 publications

(14 citation statements)

References 22 publications

(27 reference statements)

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“…Analyzing the reasons, the seizures of epilepsy are related to the impaired balance of excitability and inhibition of the central nervous system. As a classic AED, sodium valproate can interfere with the synthesis (promotion) and degradation (inhibition) of the inhibitory neurotransmitter γ -aminobutyric acid to reduce neuronal excitability and inhibit epileptic seizures but it also has the risk of causing adverse reactions such as tremor, hair loss, vomiting, and constipation [ 19 , 20 ]. Oxcarbazepineand levetiracetam are new AEDs.…”

Section: Discussionmentioning

confidence: 99%

Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy

Sun

Zhou

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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In this study, we performed a study on 106 children with epilepsy who were treated with sodium valproate (the VPA group, n = 37), oxcarbazepine (the OXC group, n = 34), or levetiracetam (the LEV group, n = 35). In addition, the clinical data of epileptic children who were newly diagnosed in the same period without antiepileptic drug (AED) treatment (the untreated group, n = 35) and normal children who received physical examination in our hospital (the healthy group, n = 35) were selected as controls. We analyzed the efficacy and safety of different AEDs, used blood ammonia and homocysteine levels as the observation indicators, and calculated the incidence of hyperammonemia (VAH) and hyperhomocysteinemia (HHcy) treated with different AEDs. And, based on the effect of epilepsy status on the cognitive function of patients, we also analyzed the effect of different AED treatments on children’s cognitive function. Our results show that sodium valproate, oxcarbazepine, and levetiracetam are all effective in the treatment of children with epilepsy and can be used as the first-line choice of antiepileptic treatment for children with epilepsy. However, compared with sodium valproate, levetiracetam and oxcarbazepine have a lower incidence of adverse drug reactions and do not cause an increase in blood ammonia and Hcy levels, so they have higher safety of drug treatment. In addition, compared with sodium valproate, levetiracetam and oxcarbazepine have better recovery of cognitive function in children with epilepsy and so they have better application value.

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Section: Discussionmentioning

confidence: 99%

Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy

Sun

Zhou

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Hair repigmentation is a possible but rare side effect of some drugs that may present with bothersome hair graying or desirable hair repigmentation like chloroquine and cancer chemotherapeutic agents as the mejor prevalent reports. Changing of hair color also has been reported by use of p-aminobenzoic acid, calcium pantothenate, anthralin, chinoform, mephenesin, minoxidil, propofol, valproic acid, and verapamil [2][3][4] .…”

Section: Discussionmentioning

confidence: 84%

Lamivudine associated hair repigmentation and a comprehensive review on reversal canities

Ghassemi¹,

Behrangi²,

Roohaninasab³

et al. 2021

PJMHS

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Background and Objective: Hair whitening is among important cosmetic problems in both genders but more annoying between women which necessitates more research about hair repigmenting methods or probable therapeutic drugs. The objective of this research was to review the mechanisms of hair pigmentation as well as the drug-related hair repigmentation. Methods: In this review article, we searched PubMed, Medline and Google scholar databases and reviewed all related articles in this area (hair repigmentation) since the reversal of canities has been an important cosmetic concern many years ago. Results: No reports of changes of hair color have been identified with lamivudine in the present research. Herein can be reported as the first case of hair repigmentation following the use of lamivudine. Conclusion: We reported a case of hair pigmentation with lamivudine for the first time that could be a desirable drug-induced side effect, also review all related articles about hair repigmention or reversal of canities. By research on probable mechanisms of drug-induced hair repigmentation, we may achieve a therapeutic strategy of hair graying as an important and highly prevalent cosmetic concern. Keywords: Lamivudine; hair repigmentation; reversal canities; drug-induced, review

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“…Similarly, cosmetic side effects such as hair loss, color changes and curling of hair have also been reported in VPA-treated patients. 41 To strengthen the predictive validity of the Clock delta19 mouse as an animal model for BD, future studies should examine whether the Clock delta19 mouse also emerges cosmetic side effects following treatment with VPA. In addition, the mechanisms of action of VPA are still not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus

Li¹,

Wei²,

Ni³

et al. 2021

NDT

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Background: Mice with a deletion at exon 19 of the circadian locomotor output cycles Kaput gene (Clock delta19) exhibit mania-like behavior and have been one of the most common animal models for bipolar disorder (BD). The predictive validity of the Clock delta19 was investigated via studies using lithium previously. Determination of effects of other mood stabilizers on Clock delta19 mouse would be helpful for better understanding of the mechanism underlined. Methods: Wildtype (WT) and Clock delta19 mice were treated with saline (n = 10 for WT and n=10 for Clock delta19) or valproate (VPA) (n = 10 for WT and n=10 for Clock delta19) for 10 days. The hyperactivity, anxiety-like behaviors and depression-like behaviors were tested. The concentration of monoamine neurotransmitters and their metabolites in the hippocampus of saline or VPA treated WT and Clock delta19 mouse (n = 8 for each) were also determined. Results: VPA can reverse hyperactivity, lower level of anxiety-like and depression-like behaviors of the Clock delta19 mouse. Clock delta19 mouse exhibited lower levels of serotonin (5-HT) and dopamine (DA) in right hippocampus compared to WT mouse. Chronic VPA treatment did not affect the levels of 5-HT and DA, but can reduce the level of levodopa (L-DOPA) in the right hippocampus of Clock delta19 mouse. Conclusion: Our results indicated that chronic VPA treatment can reverse the mania-like behaviors of the Clock delta19 mouse and further consolidate the validity of the Clock delta19 mouse as a model of BD. Monoamine neurotransmitters and their metabolites in the hippocampus are partly regulated by mutation of the Clock gene or VPA treatment.

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Valproate: It's effects on hair

Cited by 13 publications

References 22 publications

Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy

Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy

Lamivudine associated hair repigmentation and a comprehensive review on reversal canities

Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus

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