Valproate‐induced pure red cell aplasia and megakaryocyte dysplasia

Bartakke, Sandip; Abdelhaleem, Mohamed; Carção, Manuel

doi:10.1111/j.1365-2141.2008.06979.x

Cited by 9 publications

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“…Some of them had been treated with higher doses of valproate [9], and some had been taking other anticonvulsants [10] or other additional medications [11]. Our patient presented with normocellular bone marrow with qualitative abnormalities of erythropoiesis, whereas other authors have presented cases of patients with severe abnormalities of the bone marrow, such as hypocellularity, myelodysplasia, and changes resembling promyelocytic leukemia as well [1,3,12]. Thus, we believe that valproate caused dyserythropoiesis in our patient, resulting in mild macrocytic anemia.…”

Section: Discussionmentioning

confidence: 96%

Anemia secondary to valproic acid therapy in a 13-year-old boy: a case report

et al. 2012

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IntroductionValproic acid is a commonly used anti-epileptic drug. Hematological toxicities are among the occasionally observed adverse effects of this medication.Case presentationWe present the case of a 13-year-old Caucasian boy who demonstrated mild anemia 12 months after the introduction of valproic acid therapy. A bone marrow biopsy revealed maturation arrest of proerythroblasts.ConclusionPrompt diagnosis and valproic acid discontinuation resulted in the patient’s recovery.

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Section: Discussionmentioning

confidence: 96%

Anemia secondary to valproic acid therapy in a 13-year-old boy: a case report

et al. 2012

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“…Our patient had normocellular bone marrow with qualitative aberration of erythropoiesis unlike those reported by other authors like hypocellularity, myelodysplasia, changes resembling promyelocytic leukemia etc. [2,9,10]. Increase in haemoglobin, transient reticulocytosis and increased mean corpuscular volume during early weeks of follow up indicated recovery of erythroblast series.…”

Section: Discussionmentioning

confidence: 99%

Expansion of Circulating Follicular Helper T cells and their Phenotypes in Immune Thrombocytopenic Purpura and their Relation to Disease Outcome

Shafie¹,

Allam²,

Khalaf³

et al. 2017

J Hematol Thrombo Dis

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Sodium valproate is an effective antiepileptic drug used as monotherapy or adjuvant/alternative with other antiepileptic drugs. Haematological toxicity of this drug, though rare, is now an established fact and comprises mainly of neutropenia, thrombocytopenia and aplastic anemia. Very few cases of Pure Red Cell Aplasia (PRCA) following valproate therapy were reported in last 35 years but none presented as acute emergency. We report a case of a 7-year-old child suffering from absence seizure who developed features of acute heart failure due to anemia after 2 months of sodium valproate monotherapy. No underlying haematological or cardiological cause was found. Bone marrow study showed evidence of PRCA. After discontinuation of the drug patient improved gradually and never relapsed again. This case highlights the importance of haematological evaluation both clinically and by laboratory investigation during follow up visits after starting sodium valproate therapy.

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“…Antiepileptics such as diphenylhydantoin, sodium valproate, and carbamazepine were previously reported to be associated with PRCA. [3][4][5] Drugs can be responsible for various red blood cell-related syndromes, including hemolytic anemia, methemoglobinemia, PRCA, sideroblastic anemia, megaloblastic anemia, and polycythemia.…”

Section: Discussionmentioning

confidence: 99%

Carbamazepine-Induced Pure Red Cell Aplasia

Mansoor

Priya²

2018

International Journal of Epilepsy

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).Antiepileptic therapy is associated with various hematologic disorders. Pure red cell aplasia (PRCA) is a rare disease that may be congenital or acquired. Severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from an otherwise normal bone marrow should raise the suspicion of PRCA. A 32-year-old unmarried woman was admitted with fatigue for 4 months. She had been on carbamazepine therapy for 4 years (200 mg twice daily) for seizure disorder. On evaluation, she was diagnosed to have PRCA secondary to carbamazepine. We describe a patient with carbamazepine-induced PRCA that improved after discontinuation of the drug. AbstractKeywords ► antiepileptic therapy ► carbamazepine ► pure red cell aplasia Int

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Valproate‐induced pure red cell aplasia and megakaryocyte dysplasia

Cited by 9 publications

References 0 publications

Anemia secondary to valproic acid therapy in a 13-year-old boy: a case report

Anemia secondary to valproic acid therapy in a 13-year-old boy: a case report

Expansion of Circulating Follicular Helper T cells and their Phenotypes in Immune Thrombocytopenic Purpura and their Relation to Disease Outcome

Carbamazepine-Induced Pure Red Cell Aplasia

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