Valorisation of keratin waste: Controlled pretreatment enhances enzymatic production of antioxidant peptides

Cai, Ganwei; Moffitt, Kaylee; Navone, Laura; Zhang, Zhanying; Robins, Karen; Speight, Robert

doi:10.1016/j.jenvman.2021.113945

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…Several studies have demonstrated the signifcance of BAPs and their applicability in the pharmacological and pharmaceutical felds. Tey may also be used in crop development and cosmetology, though to a lesser level [179][180][181][182][183]. Tese bioactivities, especially the antibacterial potential, can be advantageous to the agri-food sector.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Microbial- and Plant-Derived Bioactive Peptides and Their Applications against Foodborne Pathogens: Current Status and Future Prospects

Parvez,

Jubyda,

Ayaz

et al. 2024

International Journal of Microbiology

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Bioactive peptides (BAPs) obtained from plants and microbes have been thoroughly explored and studied due to their prophylactic properties. The use of BAPs seems to be a promising substitute for several currently available antibiotics because of their antimicrobial properties against foodborne pathogens. BAPs have several other useful properties including antitumor, antihypertensive, antioxidant, antiobesity, and antidiabetic activities. Nowadays, scientists have attempted to recombinantly synthesize bioactive peptides to study their characteristics and potential uses, since BAPs are not found in large quantities in nature. Many pathogenic microorganisms including foodborne pathogens are becoming resistant to various antibiotics. To combat these pathogens, scientists are working to find novel, innovative, and safe antimicrobial agents. Plant- and microbe-based BAPs have demonstrated noteworthy antimicrobial activity against a wide range of pathogenic microorganisms, including foodborne pathogens. BAPs can kill pathogenic microorganisms by disrupting membrane integrity, inhibiting DNA and RNA synthesis, preventing protein synthesis, blocking protein activity, or interacting with certain intracellular targets. In addition, the positive effect of BAP consumption extends to gut microbiota modulation and affects the equilibrium of reactive oxygen species in the gut. This article discusses recombinant BAPs, BAPs generated from plants and microbes, and their antimicrobial applications and modes of action for controlling foodborne pathogens.

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Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Microbial- and Plant-Derived Bioactive Peptides and Their Applications against Foodborne Pathogens: Current Status and Future Prospects

Parvez,

Jubyda,

Ayaz

et al. 2024

International Journal of Microbiology

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“…The AA contents of FM and ileal digesta were determined as described by Cai et al (2022). Briefly, the protein sample (50 mg) was hydrolysed under nitrogen with 6 mol/L hydrochloric acid containing 5 mL dithiothreitol (DTT; 20 mM) at 110°C overnight.…”

Section: Chemical Analysismentioning

confidence: 99%

Physical treatment and protease or probiotic supplementation and feather meal digestibility by broilers

Sun,

Li,

Zhang

et al. 2024

Anim. Prod. Sci.

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Context Improving the utilisation of alternative protein ingredients in livestock production will reduce feeding costs and improve industry sustainability. Feather meal (FM) is an abundant, alternative protein source with a high protein content but poor amino acid (AA) digestibility. Aim This study evaluated strategies for improving AA digestibility of FM. Methods Experiment 1 examined the effects of physical treatment with ultrasound, microwave and autoclaving on FM AA profile and digestibility. Experiment 2 evaluated the dietary addition of a protease (Ronozyme ProAct, 200 and 600 mg/kg; RPA) and a probiotic (BioPlus 400, 1500 mg/kg) on FM AA digestibility. Apparent ileal digestibility was determined by feeding each treatment to four replicate groups of six birds in Experiment 1 and five replicate groups of seven birds in Experiment 2, and then collecting the contents of the lower half of the ileum. Key results None of the physical treatments improved (P > 0.05) the AA profile or ileal AA digestibility of FM. Dietary supplementation with RPA at 200 mg/kg or BioPlus 400 at 1500 mg/kg did not significantly (P > 0.05) influence the apparent ileal AA digestibility of FM. However, the higher concentration of RPA (600 mg/kg) significantly (P < 0.05) increased the apparent ileal AA digestibility of FM. Conclusion The increased digestibility of FM by the protease and numerical increase (P < 0.1) by the probiotic (1500 mg/kg) presumably reflects keratinase activity of both feed supplements. Implications The results of this study indicated that there is scope for further improvement in the nutritive value of FM for broilers.

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“…Many studies have shown their applicability in the pharmacological and nutraceutical fields due to their antioxidant, antidiabetic, antihypertensive, anticancer, anti-inflammatory, hypocholesterolemic, anti-hyperpigmentation, intestine-modulatory, and antimicrobial activities, among others [ 47 , 155 , 158 ]. To a lesser extent, their potential use in cosmetology and crop improvement has also been described [ 22 , 159 , 160 , 161 , 162 ].…”

Section: Prospectsmentioning

confidence: 99%

Bioactive Antimicrobial Peptides from Food Proteins: Perspectives and Challenges for Controlling Foodborne Pathogens

et al. 2023

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Bioactive peptides (BAPs) derived from food proteins have been extensively studied for their health benefits, majorly exploring their potential use as nutraceuticals and functional food components. These peptides possess a range of beneficial properties, including antihypertensive, antioxidant, immunomodulatory, and antibacterial activities, and are naturally present within dietary protein sequences. To release food-grade antimicrobial peptides (AMPs), enzymatic protein hydrolysis or microbial fermentation, such as with lactic acid bacteria (LAB), can be employed. The activity of AMPs is influenced by various structural characteristics, including the amino acid composition, three-dimensional conformation, liquid charge, putative domains, and resulting hydrophobicity. This review discusses the synthesis of BAPs and AMPs, their potential for controlling foodborne pathogens, their mechanisms of action, and the challenges and prospects faced by the food industry. BAPs can regulate gut microbiota by promoting the growth of beneficial bacteria or by directly inhibiting pathogenic microorganisms. LAB-promoted hydrolysis of dietary proteins occurs naturally in both the matrix and the gastrointestinal tract. However, several obstacles must be overcome before BAPs can replace antimicrobials in food production. These include the high manufacturing costs of current technologies, limited in vivo and matrix data, and the difficulties associated with standardization and commercial-scale production.

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Valorisation of keratin waste: Controlled pretreatment enhances enzymatic production of antioxidant peptides

Cited by 10 publications

References 30 publications

Microbial- and Plant-Derived Bioactive Peptides and Their Applications against Foodborne Pathogens: Current Status and Future Prospects

Microbial- and Plant-Derived Bioactive Peptides and Their Applications against Foodborne Pathogens: Current Status and Future Prospects

Physical treatment and protease or probiotic supplementation and feather meal digestibility by broilers

Bioactive Antimicrobial Peptides from Food Proteins: Perspectives and Challenges for Controlling Foodborne Pathogens

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