Validity of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma

Dong, Yanmei; Wang, Xiaoyun; Wang, Yanan; Liu, Yuan; Zhang, Jiawen; Qian, Wenyan; Wu, Sufang

doi:10.1097/igc.0000000000000287

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…The overall sensitivity and specificity of FDG-PET in this cohort of patients with early stage disease was comparable with those we previously reported in a smaller study11 and with those found by Nogami and colleagues 15. Other groups have reported higher sensitivity in detecting nodal metastasis in early stage cervical cancer 16 17. These retrospective study results are summarized in Table 4.…”

Section: Discussionsupporting

confidence: 90%

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with ¹⁸F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer

Lin

Wright

Dehdashti³

et al. 2019

Int J Gynecol Cancer

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Objective18F-fluorodeoxyglucose–positron emission tomography (FDG-PET) detection of metastatic nodal disease is useful for guiding cervical cancer treatment but the impact of tumor histology is unknown. This study reports the detection of FDG avid pelvic and para-aortic lymph nodes in patients with early stage cervical cancer with squamous carcinoma and adenocarcinoma tumor histology.MethodsPatients with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IB1-2 cervical cancer who underwent pre-surgical FDG-PET between March 1999 and February 2018 were identified in a tertiary academic center database. All patients had radical hysterectomy with pelvic and para-aortic lymph node dissection. Detection of pelvic and para-aortic lymph nodes by FDG-PET versus surgical dissection was compared. FDG-PET sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined and stratified by tumor histology.ResultsWe identified 212 patients with early stage cervical cancer (84% FIGO IB1, 16% IB2) who underwent pre-surgical FDG-PET; 137 (65%) patients had squamous carcinoma and 75 (35%) patients had adenocarcinoma. PET/computed tomography was performed in 189 (89%) patients and 23 (11%) had PET only. Surgical dissection revealed positive pelvic and para-aortic lymph nodes in 25% and 3.3% of patients, respectively. For squamous carcinoma, sensitivity, specificity, PPV, and NPV of FDG-PET for pelvic nodal metastasis were 44%, 99%, 95%, and 78%, respectively. For adenocarcinoma, the corresponding results for pelvic nodal metastasis were 25%, 99%, 67%, and 92%, respectively. The overall values for sensitivity, specificity, PPV, and NPV of FDG-PET for para-aortic nodal metastasis were 29%, 99%, 67%, and 98%, respectively.DiscussionPelvic nodal metastasis was less likely to be detected by FDG-PET in patients with early stage adenocarcinoma than with squamous carcinoma.

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Section: Discussionsupporting

confidence: 90%

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with ¹⁸F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer

Lin

Wright

Dehdashti³

et al. 2019

Int J Gynecol Cancer

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“…In clinical practice, imaging diagnostics, including magnetic resonance imaging (MRI), positron emission tomography (PET), and computed tomography (CT) scans, are conventional methods of PLNM detection before treatment. Nevertheless, additional statistical analyses demonstrate that these methods have poor sensitivity for detecting lymph node metastasis ( 6 , 7 ). Recently, Sentinel LN (SLN) biopsy in early-stage cervical cancer yields high diagnostic value for the status of lymph node ( 8 ), but this still need general anesthesia.…”

Section: Introductionmentioning

confidence: 99%

Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer

Shang

Zhu

et al. 2016

Oncology Reports

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Pelvic lymph node metastasis (PLNM) is an independent prognostic parameter and determines the treatment strategies of cervical cancer. Increasing evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the process of tumor biological functions. This study aimed to mine lymph node metastasis-associated lncRNAs and investigate their potential pathophysiological mechanism in cervical cancer lymph node metastasis. We applied the lncRNA-mining approach to identify lncRNA transcripts represented on Affymetrix human genome U133 plus 2.0 microarrays from Gene Expression Omnibus (GEO) and then by validation in clinical specimens. The biological role and molecular mechanism of these lncRNAs were predicted by bioinformatic analysis. Subsequently, a receiver operating characteristic (ROC) curve and survival curve were conducted to evaluate the diagnostic and prognostic value of candidate lncRNAs. In total, 234 differentially expressed lncRNAs were identified to significantly associate with pelvic lymph node metastasis in early-stage cervical cancer. Our qRT-PCR results were consistent with the mining analysis (P<0.05). The functional enrichment analysis suggested that these lncRNAs may be involved in the biological process of lymph node metastasis. The ROC curves demonstrated satisfactory discrimination power of MIR100HG and AC024560.2 with areas under the curve of 0.801 and 0.837, respectively. Survival curve also indicated that patients with high MIR100HG expression had a tendency of poor prognosis. This is the first study to successfully mine the lncRNA expression patterns in PLNM of early-stage cervical cancer. MIR100HG and AC024560.2 may be a potential biomarkers of PLNM and these lncRNAs may provide broader perspective for combating cervical cancer metastasis.

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“…In the present study, the specificity and NPV of PET/CT were 81.8% and 92.3%, respectively. In previous retrospective studies, the specificity and NPV were 88.6% and 100%, respectively [10][11][12].…”

Section: Discussionmentioning

confidence: 84%

Utility of Whole Body 18F-FDG PET/CT in Comparison to Pelvic MRI in Evaluation of Local Staging of Early-Stage Carcinoma Cervix

Singaram¹,

Hulikal²,

Devi³

et al. 2022

Cureus

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Objective: This prospective comparative study aimed to investigate the applied value of whole body 2deoxy-2[fluorine-18]fluoro-D-glucose positron emission tomography integrated with computed tomography ( 18 F-FDG PET/CT) in comparison to pelvic magnetic resonance imaging (MRI) in early cervical cancer patients.Material and methods: A prospective study was performed on 47 clinically early-stage cervical cancer patients evaluated with positron emission tomography/computed tomography (PET/CT) and MRI before surgery. The final postoperative histopathology report served as the reference standard. Both PET/CT and MRI images were analyzed and correlated with histopathologic findings concerning parametrial and lymph node involvement.Results: Sensitivity, specificity, and negative predictive value (NPV) of PET/CT were 33.3%, 81.8%, and 94.7%, respectively, for parametrium assessment. And the corresponding values of pelvic MRI were 33.3%, 63.6%, and 93.3%, respectively (PET/CT versus MRI, p > 0.05). The positive predictive value (PPV) of PET/CT (11.1%) was higher than MRI (5.9%) for parametrial assessment (p < 0.05). The sensitivity, specificity, PPV, and NPV of PET/CT were 75%, 83.7%, 30%, and 97.3%, respectively, for lymph node assessment. And the corresponding values of MRI were 75%, 81.3%, 27.3%, and 97.2%, respectively (PET/CT versus MRI, p > 0.05). There was no significant difference between MRI and PET/CT concerning stage migration (p = 0.4276). Conclusion:The PET/CT had no additional utility (compared to MRI) in the evaluation of local staging of clinically early cervical carcinoma patients.

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Validity of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma

Abstract: The cervix invasion, negative uterine body invasion, and negative lymph node invasion are effective 18F-FDG PET/CT findings.

Cited by 8 publications

References 21 publications

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with ¹⁸F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with ¹⁸F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer

Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer

Utility of Whole Body 18F-FDG PET/CT in Comparison to Pelvic MRI in Evaluation of Local Staging of Early-Stage Carcinoma Cervix

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Validity of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma

Abstract: The cervix invasion, negative uterine body invasion, and negative lymph node invasion are effective 18F-FDG PET/CT findings.

Cited by 8 publications

References 21 publications

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with 18F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with 18F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer

Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer

Utility of Whole Body 18F-FDG PET/CT in Comparison to Pelvic MRI in Evaluation of Local Staging of Early-Stage Carcinoma Cervix

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Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with ¹⁸F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with ¹⁸F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer