Validation of the Glasgow Meningococcal Septicemia Prognostic Score

Thomson, A. P. J.; Sills, J. A.; Hart, C. A.

doi:10.1097/00003246-199101000-00010

Cited by 126 publications

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“…Clinical and laboratory data were recorded throughout their hospital admission. Severity of disease was assessed using the Glasgow Meningococcal Septicaemia Prognostic Score (GMSPS) [10]. Severe disease was defined as a GMSPS of 8 or higher.…”

Section: Methodsmentioning

confidence: 99%

A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis

et al. 2005

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Objective-This study aimed to determine whether an anti-inflammatory profile in meningococcal disease is associated with an increased risk of severe disease or septic shock.Design and setting-Prospective observational study in a tertiary care children's hospital. Patients and participants-63 children with confirmed meningococcal disease.Interventions-Plasma concentrations of interleukin-1 receptor antagonist (IL-1Ra), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-α (TNF) were assayed on admission. Receiver operator characteristic curve analysis was used to determine optimum thresholds for IL-1Ra:TNF, IL-1Ra:IL-6 and IL-1Ra:IL-8 ratios.Measurements and results-Median IL-1Ra:TNF and IL-1Ra:IL-6 ratios were significantly higher in severe disease with septic shock than in severe disease without septic shock and in non severe disease (IL-1Ra:TNF 263 vs. 185 vs. 108; IL-1Ra:IL-6 139 vs. 23 vs. 17). Median IL-1Ra:IL-8 ratios were not significantly different in the three groups. A significantly larger proportion of children with high IL-1Ra:TNF-α and IL-1Ra:IL-6 ratios developed severe disease with septic shock than those with a low ratios (95.2% vs. 4.8%; 76.2% vs. 23 .8%).Conclusions-An anti-inflammatory profile appears to be associated with the development of severe disease and septic shock in meningococcal sepsis. This may imply that experimental new therapies of pro-inflammatory cytokine inhibition and anti-inflammatory cytokines in meningococcal disease could be detrimental.

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Section: Methodsmentioning

confidence: 99%

A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis

et al. 2005

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“…In contrast to the sepsis syndrome, meningococcal disease is a rapidly recognisable disease and therefore several simple scores have been developed which aim to predict outcome directly after admittance [10][11][12][13][14][15][16][17][18][19][20]. Unfortunately, most meningococcal disease scoring systems have been developed based on the analysis of small, and heterogenous, patient populations.…”

Section: Introductionmentioning

confidence: 99%

Meningococcal disease: A comparison of eight severity scores in 125 children

et al. 1996

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General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 12 May 2018Intensive Care Med (1996)

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“…17 A escala GMSPS foi durante vários anos usada em cuidados intensivos, sendo descrita uma sensibilidade que ronda os 100%. 18,19 No entanto, tem como desvantagens o elevado número de variáveis analisadas (sete), e a inclusão de parâmetros subjetivos como a opinião dos pais acerca da evolução da doença.…”

Section: Discussionunclassified

Doença Meningocócica Invasiva: Aplicação do Base Excess and Platelets Score numa Unidade de Cuidados Intensivos Pediátricos Portuguesa

et al. 2015

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Introduction:Meningococcal infection has a high mortality and morbidity. Recently a new prognostic scoring system was developed for paediatric invasive meningococcal disease, based on platelet count and base excess -base excess and platelets score. The main objective of this study was to evaluate the accuracy of base excess and platelets score to predict mortality in children admitted to intensive care due to invasive meningococcal disease. Material and Methods: Observational study, with retrospective data collection, during a 13.5 years period (01/2000 to 06/2013). Mortality by invasive meningococcal disease and related factors (organ dysfunction and multi-organ failure) were analysed. The base excess and platelets score was calculated retrospectively, to evaluate its accuracy in predicting mortality and compared with Paediatric Risk of Mortality and Paediatric Index of Mortality 2 . Results: Were admitted 76 children with invasive meningococcal disease. The most frequent type of dysfunction was cardiovascular (92%), followed by hematologic (55%). Of the total, 47 patients (62%) had criteria for multi-organ failure. The global mortality was 16%. Neurologic and renal dysfunction showed the strongest association with mortality, adjusted odds ratio 315 ( Conclusions:The Base Excess and Platelets score may be useful tool in invasive meningococcal disease because is highly sensitive and specific and is objectively measurable and readily available at presentation.

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Validation of the Glasgow Meningococcal Septicemia Prognostic Score

Cited by 126 publications

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A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis

A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis

Meningococcal disease: A comparison of eight severity scores in 125 children

Doença Meningocócica Invasiva: Aplicação do Base Excess and Platelets Score numa Unidade de Cuidados Intensivos Pediátricos Portuguesa

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