1985
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Validation of radioimmunoassay for human lactalbumin in the serum by testing the endogenous antibodies interference
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Cited by 6 publications
(4 citation statements)
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Abstract
Smart CitationsHow this paper cites the one you are viewing
“…The measurement of human serum a-lactalbumin is often hampered by the presence of endogenous cross reacting antibodies to bovine a-lactalbumin (Woods & Heath, 1978;Zangerle & Franchimont, 1985). The present study is the first report of the application of a monoclonal antibody specific for human a-lactalbumin for a radioimmunoassay which has been developed to overcome this interference by the endogenous antibodies.…”
Section: Discussion
mentioning
confidence: 84%
“…This is probably due to the presence of 'natural' antibodies to bovine alactalbumin which cross react with human x-lactalbumin (Woods & Heath, 1978). These natural antibodies, which have a higher affinity for bovine x-lactalbumin than for human a-lactalbumin (Zangerle & Franchimont, 1985), may have arisen through dietary exposure to cow's milk.…”
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…The measurement of human serum a-lactalbumin is often hampered by the presence of endogenous cross reacting antibodies to bovine a-lactalbumin (Woods & Heath, 1978;Zangerle & Franchimont, 1985). The present study is the first report of the application of a monoclonal antibody specific for human a-lactalbumin for a radioimmunoassay which has been developed to overcome this interference by the endogenous antibodies.…”
Section: Discussion
mentioning
confidence: 84%
“…This is probably due to the presence of 'natural' antibodies to bovine alactalbumin which cross react with human x-lactalbumin (Woods & Heath, 1978). These natural antibodies, which have a higher affinity for bovine x-lactalbumin than for human a-lactalbumin (Zangerle & Franchimont, 1985), may have arisen through dietary exposure to cow's milk.…”
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…mainly as a consequence of the use of heteroantisera to a-LA in the assays (26)(27)(28). A major problem with assays of human a-LA in serum is the presence of natural cross-reacting antibodies to human and bovine a-LA (13)(14)(15). These natural antibodies have a greater affinity for bovine than for human a-LA and may have arisen following dietary exposure to cow's milk.…”
Section: Discussion
mentioning
confidence: 99%
“…The discrepancies were mainly due to the lack of specificity of the antisera (13) used and/or the presence of natural antibodies in human sera that interfere with serum assays for these proteins (14,15). These problems may conceivably be overcome by using antibodies of higher specificity.…”
Section: Introduction
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…The measurement of human serum a-lactalbumin is often hampered by the presence of endogenous cross reacting antibodies to bovine a-lactalbumin (Woods & Heath, 1978;Zangerle & Franchimont, 1985). The present study is the first report of the application of a monoclonal antibody specific for human a-lactalbumin for a radioimmunoassay which has been developed to overcome this interference by the endogenous antibodies.…”
Section: Discussion
mentioning
confidence: 84%
“…This is probably due to the presence of 'natural' antibodies to bovine alactalbumin which cross react with human x-lactalbumin (Woods & Heath, 1978). These natural antibodies, which have a higher affinity for bovine x-lactalbumin than for human a-lactalbumin (Zangerle & Franchimont, 1985), may have arisen through dietary exposure to cow's milk.…”
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…mainly as a consequence of the use of heteroantisera to a-LA in the assays (26)(27)(28). A major problem with assays of human a-LA in serum is the presence of natural cross-reacting antibodies to human and bovine a-LA (13)(14)(15). These natural antibodies have a greater affinity for bovine than for human a-LA and may have arisen following dietary exposure to cow's milk.…”
Section: Discussion
mentioning
confidence: 99%
“…The discrepancies were mainly due to the lack of specificity of the antisera (13) used and/or the presence of natural antibodies in human sera that interfere with serum assays for these proteins (14,15). These problems may conceivably be overcome by using antibodies of higher specificity.…”
Section: Introduction
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…The measurement of human serum a-lactalbumin is often hampered by the presence of endogenous cross reacting antibodies to bovine a-lactalbumin (Woods & Heath, 1978;Zangerle & Franchimont, 1985). The present study is the first report of the application of a monoclonal antibody specific for human a-lactalbumin for a radioimmunoassay which has been developed to overcome this interference by the endogenous antibodies.…”
Section: Discussion
mentioning
confidence: 84%
“…This is probably due to the presence of 'natural' antibodies to bovine alactalbumin which cross react with human x-lactalbumin (Woods & Heath, 1978). These natural antibodies, which have a higher affinity for bovine x-lactalbumin than for human a-lactalbumin (Zangerle & Franchimont, 1985), may have arisen through dietary exposure to cow's milk.…”
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…mainly as a consequence of the use of heteroantisera to a-LA in the assays (26)(27)(28). A major problem with assays of human a-LA in serum is the presence of natural cross-reacting antibodies to human and bovine a-LA (13)(14)(15). These natural antibodies have a greater affinity for bovine than for human a-LA and may have arisen following dietary exposure to cow's milk.…”
Section: Discussion
mentioning
confidence: 99%
“…The discrepancies were mainly due to the lack of specificity of the antisera (13) used and/or the presence of natural antibodies in human sera that interfere with serum assays for these proteins (14,15). These problems may conceivably be overcome by using antibodies of higher specificity.…”
Section: Introduction
mentioning
confidence: 99%