Validation of MR thermometry: Method for temperature probe sensor registration accuracy in head and neck phantoms

Tarasek, Matthew; Pellicer-Guridi, Rubén; Hofstetter, Lorne W.; Numan, W C M; Bakker, Jurriaan F.; Kotek, Gyula; Togni, Paolo; Verhaart, René F.; Fiveland, Eric; Houston, J. Graeme; Rhoon, Gerard C. van; Paulides, Margarethus M.; Yeo, Desmond

doi:10.3109/02656736.2014.887794

Cited by 27 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The linear regression analysis of our phantom measurements provided robust data for each metabolites' chemical shift indicating a thorough and accurate choice of acquisition methods in agreement with the previous literature (Marshall et al, 2006;Zhu et al, 2008;Covaciu et al, 2010;Vescovo et al, 2013;Tarasek et al, 2014;Babourina-Brooks et al, 2015). However, by comparing the measured tympanic temperature with the calculated temperature from in vivo measurements, only NAA and Cr were consistent enough regarding their standard deviations.…”

Section: Discussionsupporting

confidence: 84%

Magnetic Resonance Spectroscopy Thermometry at 3 Tesla: Importance of Calibration Measurements

Verius

Frank

Gizewski

et al. 2019

Therapeutic Hypothermia and Temperature Management

View full text Add to dashboard Cite

To demonstrate the importance of calibration measurements in 3 Tesla proton magnetic resonance (MR) spectroscopy (1 H-MRS) thermometry for human brain temperature estimation for routine clinical applications. In vitro proton MR spectroscopy to obtain calibration constants of the water-chemical shift was conducted at 3 Tesla with a temperature-controlled phantom, containing a pH-buffered aqueous solution of N-acetyl aspartate (NAA), creatine (Cr), methylene protons of Cr (Cr2), dimethyl silapentane sulfonic acid (DSS), and sodium formate (NaFor). Estimations of absolute human brain temperature were performed utilizing the correlation of temperature to the water-chemical shift for the resonances of NAA, Cr, and Cr2. Data for calibration of the metabolites' chemical shift differences and in vivo temperature estimations were acquired with single-voxel point-resolved spectroscopy (PRESS) sequences (repetition time/echo time = 2000/30 ms; voxel size 2 • 2 • 2 cm 3). Spectroscopy data were quantified in the time-domain, and a Pearson correlation analysis was performed to estimate the correlation between the chemical shift of metabolites and measured temperatures. The correlation coefficients (r) of our calibration measurements were NAA 0.9975 (-0.0609), Cr-0.9979 (-0.0621), Cr2-0.9973 (-0.0577), DSS-0.9976 (-0.0615), and NaFor-0.8132 (-2.348). The mean calculated brain temperature was 37.78-1.447°C, and the mean tympanic temperature was 36.83-0.2456°C. Calculated temperatures derived from Cr and Cr2 provided significant (p = 0.0241 and p = 0.0210, respectively) correlations with measured temperatures (r = 0.4108 and r =-0.4194, respectively). Calibration measurements are vital for 1 H-MRS thermometry. Small numeric differences in measured signal and data preprocessing without any calibration measurements reduce accuracy of temperature calculations, which indicates that calculated temperatures should be interpreted with caution. Application of this method for clinical purposes warrants further investigation and a more practical approach.

show abstract

Section: Discussionsupporting

confidence: 84%

Magnetic Resonance Spectroscopy Thermometry at 3 Tesla: Importance of Calibration Measurements

Verius

Frank

Gizewski

et al. 2019

Therapeutic Hypothermia and Temperature Management

View full text Add to dashboard Cite

show abstract

“…The central heated region in this phantom corresponded very well to those obtained earlier by infrared measurements in a muscle-only split-phantom phantom for the setup without MR compatibility feature (LabCollar) [54]. This device was again validated pre-clinically in an oil-gel phantom by applying a combination of MR imaging and 3D spline fitting for accurate probe localization [55]. The result corresponds to a reduced average error of DT < 0.14 C with a maximum error of DT ¼ 0.22 C.…”

Section: Decoupled Devices (Ht-only Inserts)supporting

confidence: 78%

Systematic review of pre-clinical and clinical devices for magnetic resonance-guided radiofrequency hyperthermia

Adibzadeh

Sümser

Curto

et al. 2020

International Journal of Hyperthermia

View full text Add to dashboard Cite

Clinical trials have demonstrated the therapeutic benefits of adding radiofrequency (RF) hyperthermia (HT) as an adjuvant to radio-and chemotherapy. However, maximum utilization of these benefits is hampered by the current inability to maintain the temperature within the desired range. RF HT treatment quality is usually monitored by invasive temperature sensors, which provide limited data sampling and are prone to infection risks. Magnetic resonance (MR) temperature imaging has been developed to overcome these hurdles by allowing noninvasive 3D temperature monitoring in the target and normal tissues. To exploit this feature, several approaches for inserting the RF heating devices into the MR scanner have been proposed over the years. In this review, we summarize the status quo in MR-guided RF HT devices and analyze trends in these hybrid hardware configurations. In addition, we discuss the various approaches, extract best practices and identify gaps regarding the experimental validation procedures for MR-RF HT, aimed at converging to a common standard in this process.

show abstract

“…Given recent progress in thermal modelling [48], one can imagine further improved characterisation of pelvic temperature distribution using a combination of local thermometry, volumetric thermometry and patient specific simulations, as demonstrated for head and neck cancer [162], for example, where measurements and simulations are combined into estimated temperature maps [163]. One example of a hybrid simulation/optical probe approach recently demonstrated accurate assessment of the T 50 , based on sparse invasive probe measurements [164], but the fusion of MRI and invasive measurements in the same coordinate space is still challenging [165]. For bladder cancer, this technique might provide a good option to reconstruct the temperature within the bladder wall.…”

Section: Discussionmentioning

confidence: 99%

Thermal dosimetry for bladder hyperthermia treatment. An overview

Schooneveldt

Bakker

Balidemaj

et al. 2016

International Journal of Hyperthermia

View full text Add to dashboard Cite

The urinary bladder is a fluid-filled organ. This makes, on the one hand, the internal surface of the bladder wall relatively easy to heat and ensures in most cases a relatively homogeneous temperature distribution; on the other hand the variable volume, organ motion, and moving fluid cause artefacts for most non-invasive thermometry methods, and require additional efforts in planning accurate thermal treatment of bladder cancer. We give an overview of the thermometry methods currently used and investigated for hyperthermia treatments of bladder cancer, and discuss their advantages and disadvantages within the context of the specific disease (muscle-invasive or non-muscle-invasive bladder cancer) and the heating technique used. The role of treatment simulation to determine the thermal dose delivered is also discussed. Generally speaking, invasive measurement methods are more accurate than non-invasive methods, but provide more limited spatial information; therefore, a combination of both is desirable, preferably supplemented by simulations. Current efforts at research and clinical centres continue to improve non-invasive thermometry methods and the reliability of treatment planning and control software. Due to the challenges in measuring temperature across the non-stationary bladder wall and surrounding tissues, more research is needed to increase our knowledge about the penetration depth and typical heating pattern of the various hyperthermia devices, in order to further improve treatments. The ability to better determine the delivered thermal dose will enable clinicians to investigate the optimal treatment parameters, and consequentially, to give better controlled, thus even more reliable and effective, thermal treatments.

show abstract

Validation of MR thermometry: Method for temperature probe sensor registration accuracy in head and neck phantoms

Cited by 27 publications

References 35 publications

Magnetic Resonance Spectroscopy Thermometry at 3 Tesla: Importance of Calibration Measurements

Magnetic Resonance Spectroscopy Thermometry at 3 Tesla: Importance of Calibration Measurements

Systematic review of pre-clinical and clinical devices for magnetic resonance-guided radiofrequency hyperthermia

Thermal dosimetry for bladder hyperthermia treatment. An overview

Contact Info

Product

Resources

About