2008
DOI: 10.1007/s10439-008-9508-x
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Abstract: Glycated hemoglobin A1c (HbA1c) concentration in blood is an index of the glycemic control widely used in diabetology. The aim of the work was to validate two mathematical models of HbA1c formation (assuming irreversible or reversible glycation, respectively) and select a model, which was able to predict changes of HbA1c concentration in response to varying glycemia courses with higher accuracy. The experimental procedure applied consisted of an original combination of: in vivo continuous glucose concentration… Show more

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Cited by 17 publications
(33 citation statements)
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“…According to one of these models both stages of the reaction are reversible 19,21 while the second model assumes irreversibility of the second stage. 2,4,12 Ladyzynski et al 16 compared performance of both the models directly using the same experimental framework and demonstrating clearly that the model assuming irreversibility of the second stage of the glycation is able to predict courses of HbA1c with significantly higher accuracy than the other model. Three reaction rate constants characterizing formation and dissociation of aldimine and its rearrangement into ketoamine are needed to identify the irreversible model.…”
Section: Introductionmentioning
confidence: 97%
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“…According to one of these models both stages of the reaction are reversible 19,21 while the second model assumes irreversibility of the second stage. 2,4,12 Ladyzynski et al 16 compared performance of both the models directly using the same experimental framework and demonstrating clearly that the model assuming irreversibility of the second stage of the glycation is able to predict courses of HbA1c with significantly higher accuracy than the other model. Three reaction rate constants characterizing formation and dissociation of aldimine and its rearrangement into ketoamine are needed to identify the irreversible model.…”
Section: Introductionmentioning
confidence: 97%
“…More recently, Ladyzynski et al 16 estimated the individual k constants for one non-diabetic volunteer and two type 1 diabetic patients using the continuous glucose monitoring, obtaining values of 1.315, 1.223, and 1.234 9 10 29 L 21 mmol 21 s 21 , respectively. In this study HbA1c concentrations during identification of k values were reflecting the most specific calibration standard recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and molality was used as a measure of glucose concentration.…”
Section: Introductionmentioning
confidence: 99%
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