Validation of an automated method of three-dimensional finite element modelling of bone

Keyak, Joyce H.; Fourkas, M.G.; Meagher, J.M.; Skinner, Harry B.

doi:10.1016/0141-5425(93)90066-8

Cited by 148 publications

(90 citation statements)

References 9 publications

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“…However, the verification of surface strain by Keyak et al 44 supported the validity of the internal strain and stress predictions in the proximal femur, because surface strain is intimately related to strain inside the bone. 45 In the present study conventional Gruen zones were used; however, there is a justification for higher resolution assessment of DIC and clinical DXA data over smaller regions, such as the 4mm x 4mm virtual strain gauge zones used in this study. Gruen zones have been adopted for assessment of periprosthetic bone adaptation, but in vitro (FE, DIC) and in vivo (DXA) techniques offer more information through their higher spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

Full-field in vitro measurements and in silico predictions of strain shielding in the implanted femur after total hip arthroplasty

Chanda

Dickinson

Gupta

et al. 2015

Proc Inst Mech Eng H

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Alterations in bone strain as a result of implantation may contribute towards periprosthetic bone density changes after Total Hip Arthroplasty (THA). Computational models provide full-field strain predictions in implant-bone constructs; however, these predictions should be verified using experimental models wherever possible. In the present work, finite element (FE) predictions of surface strains in intact and implanted composite femurs were verified using digital image correlation (DIC). Relationships were sought between post implantation strain states across seven defined Gruen zones (GZ) and clinically observed longer term bone density changes. Computational predictions of strain distributions in intact and implanted femurs were compared to DIC measurements in two regions of interest. Regression analyses indicated strong linear correlation between measurements and predictions (R = 0.927 intact, 0.926 implanted) with low standard error (SE = 38µε intact, 26µε implanted). Pre-to postoperative changes in measured and predicted surface strains were found to relate qualitatively to clinicallyobserved volumetric bone density changes across seven Gruen zones: marked proximal bone density loss corresponded with a 50-64% drop in surface strain, and slight distal density changes corresponded with 4-14% strain increase. These results support the use of DIC as a pre-clinical tool for predicting post implantation strain shielding, indicative of long-term bone adaptations.

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Section: Discussionmentioning

confidence: 99%

Full-field in vitro measurements and in silico predictions of strain shielding in the implanted femur after total hip arthroplasty

Chanda

Dickinson

Gupta

et al. 2015

Proc Inst Mech Eng H

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“…In this study, a fresh validated FEM has permitted predictions of the biomechanical response of the mandible affected by the surgical BTDO process. The small differences in strains between the experimental test and the FEM could be due to practical difficulties attaching the strain gauges properly to the cortical bone surface, and critical electrical outcomes due to thermal effects during the recording process [42]. It is also important to consider the initial yield of the mandible and the support under the loading effect of the universal testing machine, and any possible slippage of the machine stick on the enamel of the tooth.…”

Section: Discussionmentioning

confidence: 99%

Biomechanics of the Canine Mandible During Bone Transport Distraction Osteogenesis

Zapata

Dechow

Watanabe

et al. 2014

Journal of Biomechanical Engineering

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This study compared biomechanical patterns between finite element models (FEMs) and a fresh dog mandible tested under molar and incisal physiological loads in order to clarify the effect of the bone transport distraction osteogenesis (BTDO) surgical process. Three FEMs of dog mandibles were built in order to evaluate the effects of BTDO. The first model evaluated the mandibular response under two physiological loads resembling bite processes. In the second model, a 5.0 cm bone defect was bridged with a bone transport reconstruction plate (BTRP). In the third model, new regenerated bony tissue was incorporated within the defect to mimic the surgical process without the presence of the device. Complementarily, a mandible of a male American foxhound dog was mechanically tested in the laboratory both in the presence and absence of a BTRP, and mechanical responses were measured by attaching rosettes to the bone surface of the mandible to validate the FEM predictions. The relationship between real and predicted values indicates that the stress patterns calculated using FEM are a valid predictor of the biomechanics of the BTDO procedures. The present study provides an interesting correlation between the stiffness of the device and the biomechanical response of the mandible affected for bone transport.

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“…Before being used to derive clinical indications, a model needs to be verified and validated (Keyak et al 1993;Dalstra et al 1995;Lengsfeld et al 1998;GomezBenito et al 2005;Viceconti et al 2005). The term verification is commonly used to indicate the process ensuring that the numerical model accurately predicts the results of the theoretical model it is based on, which means assessing its numerical accuracy.…”

Section: Organ Level: the Bone Modelmentioning

confidence: 99%

“…Subsequently, the sensitivity of the model to the uncertainties in modelling the geometry and the material properties of a human femur from the CT data needs to be assessed (Keyak et al 1993;Lengsfeld et al 1998;Bayraktar et al 2004;Taddei et al 2006a). A sensitivity analysis, based on a Monte Carlo method, was performed on three femur models generated from the in vivo CT datasets (Taddei et al 2006c).…”

Section: Organ Level: the Bone Modelmentioning

confidence: 99%

Multiscale investigation of the functional properties of the human femur

Cristofolini

Taddei

Baleani

et al. 2008

Phil. Trans. R. Soc. A.

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The mechanical strength of human bones has often been investigated in the past. Bone failure is related to musculoskeletal loading, tissue properties, bone metabolism, etc. This is intrinsically a multiscale problem. However, organ-level performance in most cases is investigated as a separate problem, incorporating only part (if any) of the information available at a higher scale (body level) or at a lower one (tissue level, cell level). A multiscale approach is proposed, where models available at different levels are integrated. A middle-out strategy is taken: the main model to be investigated is at the organ level. The organ-level model incorporates as an input the outputs from the bodylevel (musculoskeletal loads), tissue-level (constitutive equations) and cell-level models (bone remodelling). In this paper, this approach is exemplified by a clinically relevant application: fractures of the proximal femur. We report how a finite-element model of the femur (organ level) becomes part of a multiscale model. A significant effort is related to model validation: a number of experiments were designed to quantify the model's sensitivity and accuracy. When possible, the clinical accuracy and the clinical impact of a model should be assessed. Whereas a large amount of information is available at all scales, only organ-level models are really mature in this perspective. More work is needed in the future to integrate all levels fully, while following a sound scientific method to assess the relevance and validity of such an integrated model.

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Validation of an automated method of three-dimensional finite element modelling of bone

Cited by 148 publications

References 9 publications

Full-field in vitro measurements and in silico predictions of strain shielding in the implanted femur after total hip arthroplasty

Full-field in vitro measurements and in silico predictions of strain shielding in the implanted femur after total hip arthroplasty

Biomechanics of the Canine Mandible During Bone Transport Distraction Osteogenesis

Multiscale investigation of the functional properties of the human femur

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