“…The use of ISLs to measure three-dimensional human joints motion were effectively applied for either in vitro or in vivo studies (Lewandowski et al, 1997;Van Sint Jan et al, 2002), and also effectively used whenever direct fixation to bones is required (Gardner et al, 1996;Danieli et al, 2005a;Ishii et al, 1997), as an alternative approach to active robotic systems (Danieli et al, 2005b). Requirements for adequate measurements involve advanced calibration of the devices (Liu and Panjabi, 1996;Gatti et al, 2010;Gatti and Danieli, 2008;Sholukha et al, 2004;Gatti and Danieli, 2007). Several authors (Hollister et al, 1993;Roland et al, 2010;Gatti, 2012), presented and validated techniques to estimate and identify both the functional FE axis and the LR axis of the human knee.…”