Validation of a C2–C7 cervical spine finite element model using specimen-specific flexibility data

Kallemeyn, Nicole A.; Gandhi, Anup; Kode, Swathi; Shivanna, Kiran H.; Smucker, Joseph D.; Grosland, Nicole M.

doi:10.1016/j.medengphy.2010.03.001

Cited by 135 publications

(104 citation statements)

References 41 publications

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“…The minimum value was in the C5/6 segment, especially in the anterior region and the posterior region of the annulus. 17,18 These conclusions were consistent with the results in the complexity of intervertebral movement in our study. Consequently, the complexity of the movement in different segments was negatively correlated with Young's modulus of the cervical annulus.…”

Section: Discussionsupporting

confidence: 92%

The Study of Cobb Angular Velocity in Cervical Spine during Dynamic Extension–Flexion

Ren

Yuan

2016

SPINE

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Section: Discussionsupporting

confidence: 92%

The Study of Cobb Angular Velocity in Cervical Spine during Dynamic Extension–Flexion

Ren

Yuan

2016

SPINE

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“…Finite element models of the spine or spinal motion segments often employ generalized anatomical geometry or subject-specific geometry where the morphology of spinal components (e.g., vertebrae, intervertebral disks, and ligamentous structures) is described based on a specific set of imaging data, in either an explicit or idealized manner (Kallemeyn et al, 2010). However, such generic or individualized models do not allow for investigation of the full range of effects of variation in vertebral and spinal segment orientation and geometry and the influence of geometrical factors on the mechanical behavior of the spine (Laville et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Statistical Shape Modeling-Based Finite Element Model of the Cervical Spine Under Low-Level Multiple Direction Loading Conditions

Bredbenner

Eliason

Francis

et al. 2014

Front. Bioeng. Biotechnol.

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Cervical spinal injuries are a significant concern in all trauma injuries. Recent military conflicts have demonstrated the substantial risk of spinal injury for the modern warfighter. Finite element models used to investigate injury mechanisms often fail to examine the effects of variation in geometry or material properties on mechanical behavior. The goals of this study were to model geometric variation for a set of cervical spines, to extend this model to a parametric finite element model, and, as a first step, to validate the parametric model against experimental data for low-loading conditions. Individual finite element models were created using cervical spine (C3–T1) computed tomography data for five male cadavers. Statistical shape modeling (SSM) was used to generate a parametric finite element model incorporating variability of spine geometry, and soft-tissue material property variation was also included. The probabilistic loading response of the parametric model was determined under flexion-extension, axial rotation, and lateral bending and validated by comparison to experimental data. Based on qualitative and quantitative comparison of the experimental loading response and model simulations, we suggest that the model performs adequately under relatively low-level loading conditions in multiple loading directions. In conclusion, SSM methods coupled with finite element analyses within a probabilistic framework, along with the ability to statistically validate the overall model performance, provide innovative and important steps toward describing the differences in vertebral morphology, spinal curvature, and variation in material properties. We suggest that these methods, with additional investigation and validation under injurious loading conditions, will lead to understanding and mitigating the risks of injury in the spine and other musculoskeletal structures.

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“…With a few exceptions, the FEA results obtained using converged INT Model are within the range obtained from experimental tests, as reported in the literature (Figure 3). Differences between some features of INT Model and those used in these experimental tests include spine section covered (C1-C7 in the present study versus C0-C7 [29], C2-T1 [30], and C2-C7 [31]) and the method and position used to apply the moments (in the present study, application of a load on the superior surface of the C1 vertebral body along an anatomical axis while the inferior surface of the C7 vertebral body was fixed in position and direction versus, for (Figure 4). When all of these observations were taken into account, it may be concluded that INT model was validated.…”

Section: Convergence Test and Model Validation Resultsmentioning

confidence: 95%

Finite Element Analysis Study of the Influence of Simulated Surgical Methods on Kinematics of a Model of the Full Cervical Spine

Lewis¹

2016

Spine Res

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IntroductionThe consensus is that degenerative disc disease (DDD), especially in its severe form, plays a key role in the etiology of a large assortment of symptomatic disorders of the spine, among which are herniation of the nucleus pulposus, discogenic pain, loss of disc height, loss of segmental mobility, development of osteophytes along the spine, myelopathy, radiculopathy, myeloradiculopathy, and traumatic instability at one or more levels [1]. In the cervical spine, when any of these disorders is diagnosed as originating from DDD and the pain/discomfort is not relieved by a conservative treatment, such as physical therapy and intermittent traction [2], the usual recourse is to use a surgical modality, the most widely used of which are anterior cervical discectomy without fusion (ACD), anterior cervical discectomy followed by fusion (ACDF), and disc arthroplasty (implantation of a total disc replacement) (TDR) [3,4]. Other surgical modalities include percutaneous nucleotomy [5] and nucleus pulposus replacement [6].Three shortcomings of the very large body of literature on finite element analysis (FEA) of models of the cervical spine are noted. First, a model of the full cervical spine (herein, defined as C0-T1, or C0-C7, or C1-T1, or C1-C7) is used in only a few studies [7][8][9][10][11][12][13]. Second, to the best of the present workers' knowledge, there are no studies in which a model of the full intact cervical spine and its modification to simulate each of the three most widely used surgical method (ACD, ACDF, and TDR) was used. Third, in two of the studies in which a full cervical spine model was used, kinematic parameters were not determined [9,13]. This omission is surprising given the fact that many normal activities of daily living involve motion of the cervical spine. Furthermore, since, in many clinical reports, data on motions are given, this omission means that only limited discussion of the clinical relevance of the reported FEA results can be undertaken.In the present FEA study, we constructed a three-dimensional (3D) solid model of the full cervical spine (C1-C7), validated it, Finite Element Analysis Study of the Influence of Simulated Surgical Methods on Kinematics of a Model of the Full Cervical Spine AbstractIt is common that a surgical method is used to treatment pain and other problems that are diagnosed to be due to a severe form of degenerative disc disease (DDD).In the cervical spine, DDD is frequently seen at the C5-C6 level and the three most widely used surgical methods are anterior cervical discectomy without fusion (ACD), anterior cervical discectomy with fusion achieved with the aid of either an autologous or a synthetic bone graft (ACDF), and total disc replacement (TDR). The present study involved the determination of the influence of each of the three widely used surgical methods on the kinematics of the full cervical spine. For this investigations, we built a detailed three-dimensional solid model of the full cervical spine (C1-C7 levels), simulated surgical treatment at ...

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Validation of a C2–C7 cervical spine finite element model using specimen-specific flexibility data

Cited by 135 publications

References 41 publications

The Study of Cobb Angular Velocity in Cervical Spine during Dynamic Extension–Flexion

The Study of Cobb Angular Velocity in Cervical Spine during Dynamic Extension–Flexion

Development and Validation of a Statistical Shape Modeling-Based Finite Element Model of the Cervical Spine Under Low-Level Multiple Direction Loading Conditions

Finite Element Analysis Study of the Influence of Simulated Surgical Methods on Kinematics of a Model of the Full Cervical Spine

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