Validation and Prognostic Value of Plasma Lactate Measurement in Bovine Respiratory Disease

Coghe, J.; Uystepruyst, Christophe; Bureau, Fabrice; Detilleux, Johann; Art, Tatiana; Lekeux, Pierre

doi:10.1053/tvjl.2000.0487

Cited by 26 publications

(27 citation statements)

References 26 publications

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“…The inflammatory response has been studied in relation to several lipid-and carbohydrate-related metabolic changes and is known to elicit variation in blood concentrations of cholesterol, NEFA, glucose, and lactate and increase the rate of lipolysis (Hardardottir et al, 1994;Coghe et al, 2000;Kushibiki et al, 2000). Our results agree with these physiological responses underscoring alterations in lipid metabolism, as also detected by blood analysis of the cows used in this study (Table 2) in which NEFA were greater in SU than SP cows.…”

Section: Heat Shock and Endoplasmic Reticulum (Er) Stresssupporting

confidence: 86%

The effect of calving in the summer on the hepatic transcriptome of Holstein cows during the peripartal period

Shahzad

Akbar²,

Vailati-Riboni³

et al. 2015

Journal of Dairy Science

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The liver is the main metabolic organ coordinating the adaptations that take place during the peripartal period of dairy cows. A successful transition into lactation, rather than management practices alone, depends on environmental factors such as temperature, season of parturition, and photoperiod. Therefore, we analyzed the effect of calving season on the hepatic transcriptome of dairy cows during the transition period. A total of 12 Holstein dairy cows were assigned into 2 groups based on calving season (6 cows March-April, spring; 6 cows June-July, summer, SU). The RNA was extracted from liver samples obtained at -30, 3, and 35 DIM via percutaneous biopsy and hybridized to the Agilent 44K Bovine (V2) Gene Expression Microarray (Agilent Technologies Inc., Santa Clara, CA). A quantitative PCR on 22 target genes was performed to verify and expand the analyses. A total of 4,307 differentially expressed genes were detected (false discovery rate ≤0.05) in SU compared with spring. Furthermore, 73 unique differentially expressed genes were detected in SU compared with spring cows after applying a fold-change threshold ≥3 and ≤-3. For Kyoto Encyclopedia of Genes and Genomes pathways analysis of differentially expressed genes, we used the dynamic impact approach. Ingenuity Pathway Analysis software was used to analyze upstream transcription regulators and perform gene network analysis. Among metabolic pathways, energy metabolism from lipids, carbohydrates, and amino acids was strongly affected by calving in SU, with a reduced level of fatty acid synthesis, oxidation, re-esterification, and synthesis of lipoproteins, leading to hepatic lipidosis. Glycan-synthesis was downregulated in SU cows probably as a mechanism to counteract the progression of this lipidosis. In contrast, calving in the SU resulted in upregulation of gluconeogenesis but also greater use of glucose as an energy source. Among nonmetabolic pathways, the heat-shock response was obviously activated in SU cows but was also associated with inflammatory and intracellular stress response. Furthermore, data support a recent finding that cows experience endoplasmic reticulum stress around parturition. Transcription regulator analysis revealed how metabolic changes are related to important regulatory mechanisms, including epigenetic modification. The holistic analyses of the liver transcriptome response to calving in the summer at high environmental temperatures underscore how transition cows should be carefully managed during this period, as they experience alterations in liver energy metabolism and inflammatory state increasing susceptibility to health disorders in early postpartum.

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Section: Heat Shock and Endoplasmic Reticulum (Er) Stresssupporting

confidence: 86%

The effect of calving in the summer on the hepatic transcriptome of Holstein cows during the peripartal period

Shahzad

Akbar²,

Vailati-Riboni³

et al. 2015

Journal of Dairy Science

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“…34 However, we did not find blood lactate concentration to be useful in identifying early BRDC, possibly because generalized bodytissue anaerobic metabolism did not have a chance to develop because of the low percentage of pulmonary involvement. 34 However, we did not find blood lactate concentration to be useful in identifying early BRDC, possibly because generalized bodytissue anaerobic metabolism did not have a chance to develop because of the low percentage of pulmonary involvement.…”

Section: Discussionmentioning

confidence: 60%

Serial evaluation of physiologic, pathological, and behavioral changes related to disease progression of experimentally induced Mannheimia haemolytica pneumonia in postweaned calves

Hanzlicek¹,

White²,

Mosier³

et al. 2010

ajvr

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This single-pathogen challenge model successfully yielded clinical signs and pathological effects consistent with naturally acquired respiratory disease. Routine laboratory variables and subjective measures were not reliable indicators of lung involvement or the progression of pneumonia. However, activity, objectively measured with pedometers and accelerometers, appeared to be a promising indicator for early recognition of bovine respiratory disease.

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“…One of the pitfalls of this study is single blood sampling time at the day of inclusion. Even if some studies showed some predictive value of NO in diseases where hypoperfusion is well documented, many studies have indicated that repetitive measures over days of LAC are more useful than one measurement . However, the objective of the present study was to predict the outcome of DCS in field conditions, where economic factors will limit veterinary visits and where prognosis should be established as early as possible.…”

Section: Discussionmentioning

confidence: 92%

“…The cTnI was increased in some extracardiac diseases of cattle, and the highest values were obtained with DCS cases . Dosage of LAC was already evaluated as a predictor of survival in cattle affected by various diseases but has not been studied per se in DCS. Our hypothesis was that increased LAC and cTnI concentrations are associated with a negative outcome in DCS.…”

mentioning

confidence: 99%

Prognostic Value of Cardiac Troponin I and L‐Lactate in Blood of Dairy Cows Affected by Downer Cow Syndrome

Labonté¹,

Dubuc

Roy

et al. 2017

Veterinary Internal Medicne

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BackgroundThe downer cow syndrome (DCS) is a challenging health issue in the dairy industry. No cow‐side test is available to provide an accurate prognosis for DCS cases in farm settings.Hypothesis/ObjectivesLocal or systemic hypoperfusion and myocardial lesions lead to an increase in blood concentration of biomarkers cardiac troponin I (cTnI) and L‐lactate. The objective was to determine the prognostic values of these biomarkers assessed cow‐sides in addition to clinical examinations in prognostication of a negative outcome (NO: death or euthanasia within 7 days).Animals218 client‐owned dairy cows affected by DCS.MethodsIn a prospective study, animals were monitored for 60 days after inclusion of each cow. Blood cTnI and L‐lactate concentrations were measured on the day of inclusion. The prognostic accuracy of both biomarkers and physical examination variables was estimated to predict NO. A mixed multivariable logistic regression model was used for data analysis.ResultsPrevalence of NO in this study was 63% on day 7. Troponin concentrations greater than 0.7 ng/mL had sensitivity and specificity of 54.1% (95% CI: 45.3–62.7%) and 78.4% (95% CI: 67.3–87.1%), respectively, for predicting NO. Blood L‐lactate was not associated with the outcome. The multivariable model revealed that heart rate >100 bpm (OR; 95% CI: 3.7; 1.3–10.2) and cTnI > 0.7 ng/mL (OR; 95% CI: 5.5; 2.1–14.6) were associated with the risk of NO.Conclusions and Clinical ImportanceHypertroponinemia and tachycardia were associated with reduced survival in DCS cases. The use of cow‐side blood cTnI concentrations and heart rate could help to rapidly identify cows in farm setting that have poor chances of recovery and would benefit from a more aggressive treatment or euthanasia.

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Validation and Prognostic Value of Plasma Lactate Measurement in Bovine Respiratory Disease

Cited by 26 publications

References 26 publications

The effect of calving in the summer on the hepatic transcriptome of Holstein cows during the peripartal period

The effect of calving in the summer on the hepatic transcriptome of Holstein cows during the peripartal period

Serial evaluation of physiologic, pathological, and behavioral changes related to disease progression of experimentally induced Mannheimia haemolytica pneumonia in postweaned calves

Prognostic Value of Cardiac Troponin I and L‐Lactate in Blood of Dairy Cows Affected by Downer Cow Syndrome

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