Validation and Extension of the Association Between Potentially Excess Oxygen Exposure and Death in Mechanically Ventilated Children

Abstract

OBJECTIVES: "Cumulative excess oxygen exposure" (CEOE)-previously defined as the mean hourly administered Fio 2 above 0.21 when the corresponding hourly Spo 2 was 95% or above-was previously shown to be associated with mortality. The objective of this study was to examine the relationship among Fio 2 , Spo 2 , and mortality in an independent cohort of mechanically ventilated children. DESIGN:Retrospective cross-sectional study.SETTING: Quaternary-care PICU. PATIENTS:All patients admitted to the PICU between 2012 and 2021 and mechanically ventilated via endotracheal tube for at least 24 hours. INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Among 3,354 patients, 260 (8%) died. Higher CEOE quartile was associated with increased mortality (p = 0.001). The highest CEOE quartile had an 87% increased risk of mortality (95% CI, 7-236) compared with the first CEOE quartile. The hazard ratio for extended CEOE exposure, which included mechanical ventilation data from throughout the patients' mechanical ventilation time rather than only from the first 24 hours of mechanical ventilation, was 1.03 (95% CI, 1.02-1.03). CONCLUSIONS:Potentially excess oxygen exposure in patients whose oxygen saturation was at least 95% was associated with increased mortality.