Vaginal Brenner Tumor

Shaco‐Levy, Ruthy; Benharroch, Daniel

doi:10.1097/pgp.0b013e3182590ae8

Cited by 12 publications

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“…Sixteen cases of extraovarian Brenner tumors have been reported to date. They have been described in the lower abdomen or pelvic cavity such as the broad ligament and vagina, and in the testicular and paratesticular area [2, 3]. Here, we report a peculiar case of extraovarian Brenner tumor arising in the omentum that has not so far been reported in the English literature.…”

Section: Introductionmentioning

confidence: 80%

“…Ruthy Shco-Levy et al reported an extraovarian Brenner tumor that developed in the right distal vaginal wall and investigated the prior reported cases of extraovarian Brenner tumor in the English literature [2]. They found that 14 cases of extraovarian Brenner tumor have been reported with 5 in the vagina, 4 in the broad ligament, 3 in the testis, 1 in the uterus, and 1 in the paratesticular area.…”

Section: Discussionmentioning

confidence: 99%

“…The tumors were composed of epithelial cell nests resembling benign urothelium and hyalinized stroma surrounding the urothelial-type cell nests [2, 5–8]. Some epithelial cell nests showed squamous metaplasia, glandular structures, or cystic changes [2, 8].…”

Section: Discussionmentioning

confidence: 99%

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A peculiar case report of extraovarian Brenner tumor arising in the omentum

Hwang

Lee

et al. 2017

World J Surg Onc

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BackgroundBrenner tumors almost always develop in the ovary. Exceptionally, extraovarian Brenner tumors have been reported in the lower abdomen or pelvic organs. Here, we introduce a peculiar case of an extraovarian Brenner tumor arising in the omentum.Case presentationA 43-year-old woman presented with a palpable abdominal mass. Computed tomography (CT) scan revealed a 9.0-cm solid mass in the omentum. The tumor was not associated with pelvic structures, including the ovaries. It was excised under the clinical impression of an extragastrointestinal stromal tumor or neurogenic tumor. Grossly, the mass was a well-circumscribed solid tumor, with yellow-tan cut surface and minute cystic spaces. Microscopically, the tumor showed well-defined epithelial nests with variable cystic changes embedded in an abundant fibrous stroma. The cells within the nests were reminiscent of benign urothelial cells in that they had oval, frequently grooved nuclei. The epithelial cells focally showed a gradual transition into the surrounding stromal cells with short spindled features. The urothelium-like cells were positive for pancytokeratin, WT-1, p63, CK7, uroplakin-III, and GATA-3 but were negative for CD34, CD10, CK20, c-KIT, DOG-1, PAX-8, and calretinin. Morphological and immunohistochemical features of the tumor were the same as an ovarian Brenner tumor, and so it was diagnosed as an extraovarian Brenner tumor.ConclusionsAlthough the location of the tumor was very unusual, we could diagnose the tumor as an extraovarian Brenner tumor on the basis of the histologic and immunohistochemical findings. This is the first case of extraovarian Brenner tumor arising in the omentum near the stomach ever reported in the English literature.

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Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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A peculiar case report of extraovarian Brenner tumor arising in the omentum

Hwang

Lee

et al. 2017

World J Surg Onc

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“…Except for the ovary, it has been reported that BTs may also involve extraovarian tissues. Extraovarian BTs (EOBTs) are extremely rare and mainly occur around the female reproductive system such as the uterus [2,3], vagina [4][5][6][7][8], broad ligament [9][10][11][12], and omentum [13]. Another intriguing clinical observation is that EOBTs were observed occasionally in the testis [14][15][16][17] or epididymis [18], further evoking concerns regarding their origins and pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Extraovarian Brenner tumor in the uterus: a case report and review of literature

Deng

Zhu

et al. 2020

Diagn Pathol

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Background: Extraovarian Brenner tumors (EOBTs) are extremely rare and can be observed incidentally in both female and male patients, raising concerns regarding the origin of Brenner tumors. Case presentation: A 53-year-old postmenopausal woman presented with a nodular lesion in the left side of the corpus uteri, which was found at a routine health check. Macroscopically, the lesion appeared as a solid nodule with a yellowish-gray cut surface, approximately 6 cm in greatest diameter. Microscopically, the lesion consisted of well-defined epithelial nests and spindled stromal cells. Parenchymal cells expressed CK7, GATA3, CK5/6, 34βE12, and p63. A single layer of cavity-lined cells with umbrella-like shape showed apical Uroplakin III positivity. Stromal cells were positive for SMA, ER, and PR. The final diagnosis was EOBT and the patient was followed for 2 months with no recurrence. Conclusions: We report here the third case of EOBTs in the uterus. The combination of morphologic and immunohistochemical results supported the involvement of urothelial metaplasia in the development of EOBTs. The similarities between EOBTs and Walthard nests made Müllerian epithelium an attractive candidate as the cellular origin. Changes of tissue structure or sex hormones imbalance may lead to the translocation of Müllerian remnants to distant organs, explaining the pathogenesis of EOBTs.

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“…Brenner tumors are classified into three categories according to the World Health Organization, namely benign, borderline and malignant (3). Extraovarian Brenner tumors are extremely rare, and are mainly found in the broad ligament, uterus, vagina, testis and epididymis (4)(5)(6)(7). In the present study, we report a case of Brenner tumor of the right testis and discuss the clinical and pathological characteristics of this disease.…”

Section: Introductionmentioning

confidence: 99%

Brenner tumor of the testis: A case report and review of the literature

Quan

Jin

et al. 2016

Molecular and Clinical Oncology

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Abstract. Brenner tumor is a rare type tumor, which mainly develops in the ovaries and rarely in the adnexal region and urinary system. To the best of our knowledge, only 5 cases of testicular Brenner tumor have been reported to date. In this report, we present the case of a 55-year-old patient who noted a swelling of the right scrotum for ~20 days. The clinical suspicion was an epididymal cyst. However, following surgical resection and subsequent pathological examination, the mass was diagnosed as a testicular Brenner tumor. A supplementary review of previously published cases and literature is also presented. The aim of this report is to help elucidate this disease and reduce the rate of clinical and pathological misdiagnosis. IntroductionBrenner tumor, an uncommon subtype of surface epithelialstromal tumors, which are a class of ovarian neoplasms, was first described by Brenner in 1907 (1). It is an uncommon neoplasm, accounting for ~1.4-2.5% of all ovarian tumors (2). Brenner tumors are classified into three categories according to the World Health Organization, namely benign, borderline and malignant (3). Extraovarian Brenner tumors are extremely rare, and are mainly found in the broad ligament, uterus, vagina, testis and epididymis (4-7). In the present study, we report a case of Brenner tumor of the right testis and discuss the clinical and pathological characteristics of this disease. The study was approved by the Ethics Committee of Peking University Shenzhen Hospital (Shenzhen, China) and written informed consent was obtained from the patient for the publication of the case details. Case reportThe patient, a A 55-year-old man presented with a swelling of the right scrotum for ~20 days. There were no obvious precipitating or alleviating factors. The patient experienced a painless sensation of heaviness of the right testis. The only positive physical finding was a mildly tender mass in the right scrotum. The results of the laboratory and imaging examinations (hemogram, urinalysis, β-human chorionic gonadotropin, a-fetoprotein, liver and kidney function tests and chest X-ray) were normal. However, the results of a superficial color Doppler ultrasound examination suggested that the right scrotum had multiple cystic lesions, and an epididymal was considered as the possible clinical diagnosis.Following the doctors' recommendation, the patient consented to right epididymal cystectomy in Novermber, 2013. During the operation, the cyst was found to be located between the testis and the head of the epididymis and was sized ~50x30 mm. The cyst exhibited inflammatory adhesions to the surrounding organs, although invasion was not observed. On gross pathological examination, the resected specimen was a cyst with a thin wall (1 mm), sized 6.5x4x3.5 cm, containing a clear liquid. On microscopic examination, the fibrous cystic wall was coated with a monolayer or stratified squamous epithelium. Epithelium-like nests and a small quantity of epididymal canal tissue were also identified (Fig. 1). The pathological diagnosis...

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Vaginal Brenner Tumor

Cited by 12 publications

References 10 publications

A peculiar case report of extraovarian Brenner tumor arising in the omentum

A peculiar case report of extraovarian Brenner tumor arising in the omentum

Extraovarian Brenner tumor in the uterus: a case report and review of literature

Brenner tumor of the testis: A case report and review of the literature

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