2005
DOI: 10.1016/j.ejheart.2004.10.012
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: We have documented a pre-junctional h-2 adrenoceptor mediated reduction in cardiac norepinephrine spillover (CNES) in heart failure patients receiving chronic h-blockade. Our present objective was to ascertain the consequence of this decrease for vagal heart rate (HR) regulation by determining CNES, arterial baroreflex sensitivity for HR (BRS) and arterial baroreflex modulation of muscle sympathetic nerve activity (MSNA) before and upon 4 months of h-blockade with either carvedilol or metoprolol. In 19 heart f… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
20
0
2

Year Published

2007
2007
2022
2022

Publication Types

Select...
7
2

Relationship

2
7

Authors

Journals

citations
Cited by 30 publications
(24 citation statements)
references
References 6 publications
2
20
0
2
Order By: Relevance
“…26 In heart failure, where chronic ␤-adrenergic antagonism has been demonstrated to improve longevity, this drug class augments reflex vagal-HR modulation at an efferent site of interaction involving blockade of cardiac sympathetic prejunctional ␤2 adrenoceptors that facilitate norepinephrine release. 27 The potential use of BNT as a complementary antihypertensive treatment is further supported by the exploratory finding, albeit in a small sample, that ambulatory 24-hour SBP was reduced below the clinical threshold of 130 mm Hg for 1 of every 7 BNT subjects, representing an absolute risk reduction of 14% in comparison with AC. This modest exploratory outcome suggests that there is merit in conducting a larger scale trial to evaluate the long-term clinical efficacy of BNT.…”
Section: Nolan Et Al Behavioral Neurocardiac Training and Hypertensionmentioning
confidence: 66%
“…26 In heart failure, where chronic ␤-adrenergic antagonism has been demonstrated to improve longevity, this drug class augments reflex vagal-HR modulation at an efferent site of interaction involving blockade of cardiac sympathetic prejunctional ␤2 adrenoceptors that facilitate norepinephrine release. 27 The potential use of BNT as a complementary antihypertensive treatment is further supported by the exploratory finding, albeit in a small sample, that ambulatory 24-hour SBP was reduced below the clinical threshold of 130 mm Hg for 1 of every 7 BNT subjects, representing an absolute risk reduction of 14% in comparison with AC. This modest exploratory outcome suggests that there is merit in conducting a larger scale trial to evaluate the long-term clinical efficacy of BNT.…”
Section: Nolan Et Al Behavioral Neurocardiac Training and Hypertensionmentioning
confidence: 66%
“…103 Recent data suggest that ␤-blockade with metoprolol or carvedilol in HF can augment reflex vagus nerve control of heart rate by blockade of cardiac sympathetic prejunctional ␤2 receptors that facilitate norepinephrine release. 104 In an animal model of HF, the density of M 2 receptors was increased in the carvedilol-treated group, especially in endocardial tissues of the LV free wall. 105 Clinically, the putative role of carvedilol in the modulation of parasympathetic activity was inferred as a result of improvements in heart rate variability measurements.…”
Section: Therapeutic Strategies To Enhance Parasympathetic Tonementioning
confidence: 99%
“…15 Autonomic regulation of the heart plays a key role in cardiovascular functioning. 16,17 Poor cardiac autonomic regulation has been implicated in heart failure, 18,19 and increased vagal input (through vagal nerve stimulation or pharmacological modulators) is protective against ventricular fibrillation 20,21 and sudden cardiac death. 22 Heart rate variability (HRV), the assessment of beat-to-beat variation in the heart over time, provides a reliable index of cardiac autonomic funtion.…”
Section: Introductionmentioning
confidence: 99%