Vaccines for preventing malaria (pre-erythrocytic)

Abstract

Graves PM, Gelband H. Vaccines for preventing malaria (pre-erythrocytic).

Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model

“…This profile is precisely corroborated by results for leading CSP-containing RTS,S, vaccine formulations. These protect malaria-naïve adults partially [12] , [13] , endemic-area infants (2–17 month-old) similarly partially [9] , [10] , [11] , older children poorly [7] , [8] , [342] and endemic-area adults negligibly [1] , [14] , [15] .…”

Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model

“…This profile is precisely corroborated by results for leading CSP-containing RTS,S, vaccine formulations. These protect malaria-naïve adults partially [12] , [13] , endemic-area infants (2–17 month-old) similarly partially [9] , [10] , [11] , older children poorly [7] , [8] , [342] and endemic-area adults negligibly [1] , [14] , [15] .…”

Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions

“…Pre-erythrocytic vaccines prevent liver-stage infections by targeting the sporozoite stage (injected by the bite of an infected female Anopheles mosquito) before the parasite reaches the blood stream [ 27 ]. These vaccines can induce both antibody-mediated and cellular immune responses.…”

Highlighting the Historical, Current, and Future Challenges to Control and Eradicate Malaria in Uganda - A Narrative Review

“…(Access, 2012). One such project is Progress made on RTS, S vaccine effective in preventing a great number of clinical malaria episodes and its progression towards licensing status already justified (Pm, Gelband, Graves, & Gelband, 2010). One similar study has already suggested that, since the malaria community is considering the main role of a first-generation malaria vaccine to control malaria, it is very important to also strategically document the halted as well as ongoing research projects on the malaria vaccine.…”

Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model

“…This profile is precisely corroborated by results for leading CSP-containing RTS,S, vaccine formulations. These protect malaria-naïve adults partially [12] , [13] , endemic-area infants (2–17 month-old) similarly partially [9] , [10] , [11] , older children poorly [7] , [8] , [342] and endemic-area adults negligibly [1] , [14] , [15] .…”

Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions

“…Pre-erythrocytic vaccines prevent liver-stage infections by targeting the sporozoite stage (injected by the bite of an infected female Anopheles mosquito) before the parasite reaches the blood stream [ 27 ]. These vaccines can induce both antibody-mediated and cellular immune responses.…”

Highlighting the Historical, Current, and Future Challenges to Control and Eradicate Malaria in Uganda - A Narrative Review

“…(Access, 2012). One such project is Progress made on RTS, S vaccine effective in preventing a great number of clinical malaria episodes and its progression towards licensing status already justified (Pm, Gelband, Graves, & Gelband, 2010). One similar study has already suggested that, since the malaria community is considering the main role of a first-generation malaria vaccine to control malaria, it is very important to also strategically document the halted as well as ongoing research projects on the malaria vaccine.…”

Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model

“…This profile is precisely corroborated by results for leading CSP-containing RTS,S, vaccine formulations. These protect malaria-naïve adults partially [12] , [13] , endemic-area infants (2–17 month-old) similarly partially [9] , [10] , [11] , older children poorly [7] , [8] , [342] and endemic-area adults negligibly [1] , [14] , [15] .…”

Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions

“…Pre-erythrocytic vaccines prevent liver-stage infections by targeting the sporozoite stage (injected by the bite of an infected female Anopheles mosquito) before the parasite reaches the blood stream [ 27 ]. These vaccines can induce both antibody-mediated and cellular immune responses.…”

Highlighting the Historical, Current, and Future Challenges to Control and Eradicate Malaria in Uganda - A Narrative Review

“…(Access, 2012). One such project is Progress made on RTS, S vaccine effective in preventing a great number of clinical malaria episodes and its progression towards licensing status already justified (Pm, Gelband, Graves, & Gelband, 2010). One similar study has already suggested that, since the malaria community is considering the main role of a first-generation malaria vaccine to control malaria, it is very important to also strategically document the halted as well as ongoing research projects on the malaria vaccine.…”