1992
DOI: 10.1590/s0074-02761992000800003 View full text |Buy / Rent full text
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Abstract: In this review the authors analyze the effector and regulatory mechanisms in the immune response to schistosomiasis. To study these mechanisms two animal models were used, mouse and rat. The mouse totally permissive host like human, show prominent-T cell control in the acquisition of resistance. But other mechanisms like antibody mediated cytotoxicity (ADCC) involving eosinophils and IgG antibodies described in humans, are observed in rats. Also in this animal, it is observed specific IgE antibody high product… Show more

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“…Extensive work has been carried out to identify schistosome molecules that confer partial but significant protection in different animal models. These include the Schistosoma mansoni 28-kDa and the S. japonicum 26-kDa glutathione S-transferase (GST) (5,32), the S. mansoni and S. japonicum 97-kDa paramyosin (13,25), the S. mansoni 28-kDa triose phosphate isomerase (29), the S. mansoni 23-kDa integral membrane antigen (24), and so forth. These vaccine candidates were selected by the World Health Organization for a series of independent trials to test their protective efficacy in laboratory animals (2).…”
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“…Extensive work has been carried out to identify schistosome molecules that confer partial but significant protection in different animal models. These include the Schistosoma mansoni 28-kDa and the S. japonicum 26-kDa glutathione S-transferase (GST) (5,32), the S. mansoni and S. japonicum 97-kDa paramyosin (13,25), the S. mansoni 28-kDa triose phosphate isomerase (29), the S. mansoni 23-kDa integral membrane antigen (24), and so forth. These vaccine candidates were selected by the World Health Organization for a series of independent trials to test their protective efficacy in laboratory animals (2).…”
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“…The list of antigens and associated prophylactic efficacy has been extensively reviewed in the last few years. 10,12,16,27,[42][43][44][45] From all of these antigens, only one S. hematobium antigen, Sh-28-GST, has advanced into clinical trials, though this occurred over a decade ago and detailed findings are not available. 46 Another important schistosome antigen, Sm-14, a fatty acid binding protein has also been developed for clinical trials.…”
Section: Vaccine Candidates and Search Of Functionally Important Vaccmentioning
“…However, in order to attain the goal of filariasis elimination, it is desirable to have more than one control tool. Recently, great deal of interest has been generated in the possibility of blocking the development and transmission of parasites by vectors of diseases such as leishmaniasis (Tonui 1999), schistosomiasis (Capron et al 1992), and Lyme disease (de Silva et al1996). In the case of malaria, transmission-blocking vaccines have reached advanced stage of development (Kaslow 1997, Carter 2001.…”
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“…Vector transmission-blocking antibodies have been reported with respect to other parasites causing malaria (Khurna & Talib 1996, Carter 2001, leishmaniasis (Tonui 1999), schistosomiasis (Capron et al 1992), and Lyme disease (de Silva et al 1996). With respect to filarial parasites, a monoclonal antibody, MF1, has been reported to degrade the chitin containing structures in the microfilaria or in its mosquito vector during B. malayi development and transmission (Fuhrman et al1992).…”
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