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Cited by 1,015 publications
(689 citation statements)
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“…Some of the rare or unique changes (144 aspartic acid-alanine and 145 glycine-arginine) have also been found in newborns of carrier mothers who developed HBV infection despite prophylaxis with HBIG and vaccination. 7,[19][20][21] The glycine-to-arginine substitution at codon 145 has been shown to reduce binding to monoclonal as well as polyclonal anti-HBs. 9,11,13,22,23 In addition, synthetic peptides with a proline-to-serine substitution at codon 142, aspartic acid-to-alanine substitution at 144, and glycine-to-arginine substitution at 145 have been shown to have reduced binding to anti-HBs compared with wild-type HBsAg.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Some of the rare or unique changes (144 aspartic acid-alanine and 145 glycine-arginine) have also been found in newborns of carrier mothers who developed HBV infection despite prophylaxis with HBIG and vaccination. 7,[19][20][21] The glycine-to-arginine substitution at codon 145 has been shown to reduce binding to monoclonal as well as polyclonal anti-HBs. 9,11,13,22,23 In addition, synthetic peptides with a proline-to-serine substitution at codon 142, aspartic acid-to-alanine substitution at 144, and glycine-to-arginine substitution at 145 have been shown to have reduced binding to anti-HBs compared with wild-type HBsAg.…”
Section: Discussionmentioning
confidence: 99%
“…5,6 This region is conformational and is thought to consist of two loops held by disulfide bridges between cysteines 124 and 137, and cysteines 138 and 147. 7 The second loop is more conserved and confers most of the antigenicity of the 'a' determinant; this loop is sometimes referred to as the major hydrophilic region (MHR). HBV can be classified into four major subtypes: adr, adw, ayr, and ayw.…”
mentioning
confidence: 99%
“…As mentioned previously, the 'a' determinant is a highly conserved region of HBsAg, and contains the majority of epitopes that host anti-HBs antibodies will target. Mutations within the 'a' determinant have been observed in persons who have received the HBV vaccine in several regions of the world [4,[94][95][96]. The selective pressure may increase the emergence of surface mutants compared to wild-type.…”
Section: Global Usementioning
confidence: 99%
“…Hepatitis B virus (HBV) variants have been reported to arise in immunized individuals in three situations : (i) after liver transplantation, despite treatment with monoclonal antibodies against surface antigen (antiHBs) and hyper-immunoglobulin (HBIG) treatment [1][2][3], (ii) neonatal infections, despite HBIG and\or vaccination in the UK [4], Italy [5], Singapore [6], Indonesia [7] and Japan [8], and (iii) horizontal infections in young children despite vaccination in The Gambia [9]. The 22 nm subviral surface antigen peptides (HBsAg) used in the current vaccines (both plasma derived and recombinant) produce a narrower immune response than immunity following infection.…”
Section: Introductionmentioning
confidence: 99%