V<scp>irulence</scp>F<scp>actors of</scp><i>E<scp>nterococcus faecalis:</scp></i>R<scp>elationship to</scp>E<scp>ndodontic</scp>D<scp>isease</scp>

Kayaoğlu, Güven; Ørstavik, Dag

doi:10.1177/154411130401500506

Cited by 394 publications

(285 citation statements)

References 191 publications

(207 reference statements)

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“…18 There is evidence that the presence of E. faecalis in teeth with filled canals, cases of chronic apical periodontitis, 24 and infections after endodontic treatments are due to its high resistance to antimicrobials, 3,21 its survival for long periods in environments deprived of nutrients and oxygen, 24 and its high virulence. These characteristics of E. faecalis are likely a result of its production of aggregation substances, surface adhesins, extracellular superoxide, lytic enzyme gelatinase, and hyaluronidase.…”

Section: Discussionmentioning

confidence: 99%

In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis

et al. 2015

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The aim of this study was to evaluate the in vitro antimicrobial activity of Brazilian brown propolis as an intracanal medication against Enterococcus faecalis. Thirty dentin discs prepared from intact freshly extracted bovine maxillary central incisors were infected with E. faecalis for 21 days. The specimens were distributed into six groups according to the medicament used as follows: G1-calcium hydroxide paste; G2-Carbowax 400 (control group); G3-20% brown propolis paste; G4-40% brown propolis paste; G5-20% brown propolis paste + calcium hydroxide paste; and G6-40% brown propolis paste + calcium hydroxide paste. The experimental pastes were placed into the canal lumen and left for 14 days. After each period, irrigation was performed with sterile saline to remove the medicament, and the canals were dried with sterile paper points. The dentin chips were removed from the canals with sequential sterile round burs at low speed and were immediately collected in separate test tubes containing BHI broth. The tubes were incubated at 37°C, and microbial growth was analyzed by spectrophotometry after 15 days. All the experimental medications significantly reduced the number of viable bacteria. The G4 and G5 pastes were more effective than the G1 paste, with 35.8%, 41%, and 21.3% antibacterial activity, respectively. Brazilian brown propolis shows antibacterial capacity against E. faecalis.

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Section: Discussionmentioning

confidence: 99%

In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis

et al. 2015

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“…the enterococcal surface protein, Esp) and aggregation substances (Aggs) (reviewed by Kayaoglu & Østavik, 2004). Esp was found to be enriched in infectionderived enterococcal strains (Shankar et al, 1999) and it is associated with enhanced adhesion to abiotic surfaces and biofilm formation by E. faecalis (Toledo-Arana et al, 2001;Tendolkar et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Several traits of E. faecalis are described as virulence factors (reviewed by Kayaoglu & Østavik, 2004), and adhesion to biotic and abiotic surfaces is one of them. E. faecalis is one of the predominant organisms found in biofilms in clogged biliary stents, used to palliate obstructions of the biliary and pancreatic ducts (Dowidar et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Enterococcus faecalis strains show culture heterogeneity in cell surface charge

et al. 2006

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Adhesion of micro-organisms to biotic and abiotic surfaces is an important virulence factor and involves different types of interactions. Enterococcus faecalis, a human commensal and an important opportunistic pathogen, has the ability to adhere to surfaces. Biliary stents frequently become clogged with bacterial biofilms, with E. faecalis as one of the predominant species. Six E. faecalis strains isolated from clogged biliary stents were investigated for the presence of specific biochemical factors involved in their adhesion: aggregation substances (Aggs) and the enterococcal surface protein (encoded by the esp gene). In addition, physico-chemical factors involved in adhesion (zeta potential and cell surface hydrophobicity) were determined, as well as the influence of ox bile on these properties. Two-thirds of the biliary stent isolates displayed culture heterogeneity in the pH dependence of their zeta potentials. Moreover, 24 out of 46 clinical isolates of E. faecalis, including 11 laboratory strains, also displayed such heterogeneity. The culture heterogeneity was demonstrated to be a stable trait, not caused by quorum sensing, not plasmid mediated, and independent of the presence of esp and Agg. Data presented show that culture heterogeneity in zeta potential enhances adhesion to an abiotic surface. A higher prevalence of culture heterogeneity in zeta potential in pathogenic as compared to non-pathogenic isolates could indicate that this phenomenon might play a role in virulence and putatively in pathogenesis.

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“…E. faecalis has displayed resistance to a wide range of antibiotics [15]. Moreover, it has been found that the effective proton pump mechanism which maintains optimal cytoplasmic pH levels of these species may participate in their resistance to the antimicrobial effects of calcium hydroxide [54].…”

Section: Discussionmentioning

confidence: 99%

“…E. faecalis, in particular, is difficult to remove owing to its considerable virulence factors constituting a source of recurrent infection after conservative as well as surgical treatments [15]. P. acnes is an anaerobic Grampositive bacterium responsible for a wide range of infections and inflammatory conditions [16].…”

Section: Introductionmentioning

confidence: 99%

Influence of a polymerizable eugenol derivative on the antibacterial activity and wettability of a resin composite for intracanal post cementation and core build-up restoration

2016

Br Dent J

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. Influence of a polymerizable eugenol derivative on the antibacterial activity and wettability of a resin composite for intracanal post cementation and core build-up restoration. Dental Materials, 32(7), 929-939. DOI: 10.1016929-939. DOI: 10. /j.dental.2016 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policyIf you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. AbstractObjectives: Eugenol has been used in dentistry due to its ability to inhibit the growth of a range of microorganisms, including facultative anaerobes commonly isolated from infected root canals. The aim of this study was to evaluate the antibacterial activity of the experimental composites containing eugenyl methacrylate monomer (EgMA), a polymeric derivative of eugenol, against a range of oral bacteria, commonly associated with failure of coronal and endodontic restorations. In vitro composite behaviour and wettability were also studied in conjunction with their antibacterial activity.

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VirulenceFactors ofEnterococcus faecalis:Relationship toEndodonticDisease

Cited by 394 publications

References 191 publications

In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis

In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis

Enterococcus faecalis strains show culture heterogeneity in cell surface charge

Influence of a polymerizable eugenol derivative on the antibacterial activity and wettability of a resin composite for intracanal post cementation and core build-up restoration

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