V.—monilia Candida Infection of the Mouth

Engman, Martin F.

doi:10.1001/archderm.1920.02350020002001

Cited by 9 publications

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“…Robinson &Tasker (1947) suggested that chronic candidiasis might be pre cancerous, and there have been a number of reports of carcinoma developing in relation to lesions of chronic candidiasis. The earliest of these was that of Engman & Weiss (1920), while more recently Kugelman, Cripps & Harrell (1963), Jansen, Dilaha & Honeycutt (1963), Williamson (1969), and Eyre & Nally (1971) have reported cases. It is probable that the small number of reported cases has been due to the common failure, which Robinson & Tasker (1947) emphasized, to recognize chronic candidiasis in the past.…”

Section: Progress Of Superficial Candidiasismentioning

confidence: 99%

Induction of epithelial hyperplasia by Candida albicans

Cawson

1973

Br J Dermatol

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SUMMARY Epithelial hyperplasia is a characteristic feature of mucosal infection by Candida albicans, but doubt may exist as to the extent to which this reaction is a direct result of fungal invasion. An experimental model using the chick embryo chorio‐allantoic membrane infected by C. albicans shows an essentially similar hyperplastic response of the ectoderm, and several features in common with human infections. It is suggested that the intracellular growth of C. albicans in epithelium is probably a major factor provoking this response.

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Section: Progress Of Superficial Candidiasismentioning

confidence: 99%

Induction of epithelial hyperplasia by Candida albicans

Cawson

1973

Br J Dermatol

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“…Scattered reports of malignant transformation occurring in chronic candidal lesions of the oral mucosa have appeared in the dental/medical literature for the past 70 years (1)(2)(3)(4)(5)(6)(7)(8)(9). Typically the malignant change would develop in longstanding white patches which histologically showed candidal hyphae embedded in a prominent, thickened parakeratin layer.…”

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confidence: 99%

Resolution of candidal lesions of the dorsal rat tongue by ketoconazole

Allen

Rossie

Haring

et al. 1988

J Oral Pathology Medicine

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The purpose of this study was to determine whether the mucosal alterations of the dorsal rat tongue produced by Candida albicans infection were reversible upon treatment with the antifungal drug ketoconazole. Following experimentally‐produced infection, 17 rats showed clinical evidence of persistent lesions over a period of 20 weeks. Eight of these animals were then treated with ketoconazole daily for 2 weeks (20 mg/kg/day). Appropriate non‐infected controls and ketoconazole‐only controls were also maintained. Five weeks after the ketoconazole treatment, all animals were killed and the dorsal tongues evaluated clinically and histologically. Control groups showed no abnormalities. Of the 8 animals in the treated‐lesion group, all showed lesional resolution, while only 2 of the 9 animals in the untreated‐lesion group showed resolution of their lesions (p=0.002). These findings indicate that the epithelial changes produced by this candidal isolate for this period of time are reversible.

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Late-Onset Chronic Mucocutaneous and Ocular Candidiasis and Malignant Thymoma

Palestine¹

1983

Arch Dermatol

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V.—monilia Candida Infection of the Mouth

Cited by 9 publications

References 0 publications

Induction of epithelial hyperplasia by Candida albicans

Induction of epithelial hyperplasia by Candida albicans

Resolution of candidal lesions of the dorsal rat tongue by ketoconazole

Late-Onset Chronic Mucocutaneous and Ocular Candidiasis and Malignant Thymoma

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