UV-assisted treatment on hydrophobic acrylic IOLs anterior surface with methacryloyloxyethyl phosphorylcholine: Reducing inflammation and maintaining low posterior capsular opacification properties

Huang, Xiaodan; Luo, Chenqi; Lin, Lin; Zhang, Li; Li, Heyi; Yao, Ke; Xu, Zuhua

doi:10.1016/j.msec.2017.03.029

Cited by 18 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flaw is that plasma technology requires vacuum equipment and takes a long time to accomplish. Huang then tried to graft MPC onto hydrophobic acrylate to construct a hydrophilic interior surface by ultraviolet irradiation ( Huang et al, 2017 ) ( Figure 4 ). This method grafted MPC on the surface of IOL more efficiently.…”

Section: Intraocular Lens Surface Modification Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Luo

Wang

Chen

et al. 2022

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Advances in cataract surgery have increased the demand for intraocular lens (IOL) materials. At present, the progress of IOL materials mainly contains further improving biocompatibility, providing better visual quality and adjustable ability, reducing surgical incision, as well as dealing with complications such as posterior capsular opacification (PCO) and ophthalmitis. The purpose of this review is to describe the research progress of relevant IOL materials classified according to different clinical purposes. The innovation of IOL materials is often based on the common IOL materials on the market, such as silicon and acrylate. Special properties and functions are obtained by adding extra polymers or surface modification. Most of these studies have not yet been commercialized, which requires a large number of clinical trials. But they provide valuable thoughts for the optimization of the IOL function.

show abstract

Section: Intraocular Lens Surface Modification Materialsmentioning

confidence: 99%

“… The modified IOL from Huang et al (2017) , with the permission of Elsevier. MPC, 2-methacryloyloxyethyl phosphorylcholine.…”

Section: Intraocular Lens Surface Modification Materialsmentioning

confidence: 99%

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Luo

Wang

Chen

et al. 2022

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…At present, in addition to the optimization of IOL shape and development of novel IOL materials, IOL surface modification, which is easy to prepare and does not require extra intraocular surgery also contributes to PCO prevention [ 6 , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. In previous studies, researchers mainly focused on hydrophilic coating on the IOL surface to prevent the adhesion of LECs [ [19] , [20] , [21] , [22] ]. However, recent studies have shown that hydrophilic coating can only initially reduce LECs adhesion and proliferation on the surface but do not inhibit PCO in the long term [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

Zhu

Huang

Liu

et al. 2022

Bioactive Materials

View full text Add to dashboard Cite

“…For example, an enhanced hydrophobic surface was constructed by fluorination on IOL, aiming at reducing cell adhesion. More studies have been focused on hydrophilic surface construction to minimize cell adhesion for PCO prevention in recent years, such as immobilizing heparin, poly(ethylene glycol), or phosphatidylcholine molecules onto the IOL surface. − However, drug injection causes concomitant side effects to the nearby ocular tissues, whereas the biologically inert surface modification alone just delays PCO formation but cannot prevent its development in long-term observations . Due to the effective PCO-prevention performance, the drugs were introduced into the IOL materials to prepare drug-eluting IOLs for PCO prevention.…”

Section: Introductionmentioning

confidence: 99%

Drug-Eluting Hydrophilic Coating Modification of Intraocular Lens via Facile Dopamine Self-Polymerization for Posterior Capsular Opacification Prevention

Liu

Zhao

Tang

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Posterior capsular opacification (PCO) is the most important complication in cataract phacoemulsification and intraocular lens (IOL) implantation surgery, mainly stemming from the adhesion, proliferation, and transdifferentiation of the postsurgically residual lens epithelial cells (LECs). Previous investigations mainly focused on the hydrophilic surface modification of the IOLs for PCO prevention, such as heparinization. However, the long-term clinical investigations show that there is no significant difference between pristine and heparinized IOLs. In the present study, a synergetic coating with properties of drug-eluting and hydrophilicity was designed and modified onto the IOL surface via facile dopamine self-polymerization. The antiproliferative drug doxorubicin (DOX) was loaded when a polydopamine (PDA) coating was formed on the IOL surface. The hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) could be subsequently grafted onto the drug-loaded PDA coating surface easily. The hydrophilic outer layer could slow down drug-eluting from underneath the drug-incorporated coating. In vitro and in vivo investigations demonstrated that such multifunctionalized coating-modified IOLs could not only thoroughly and effectively prevent PCO development by induced cell apoptosis but also render safety and biocompatibility to the surrounding tissues.

show abstract

UV-assisted treatment on hydrophobic acrylic IOLs anterior surface with methacryloyloxyethyl phosphorylcholine: Reducing inflammation and maintaining low posterior capsular opacification properties

Cited by 18 publications

References 35 publications

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

Drug-Eluting Hydrophilic Coating Modification of Intraocular Lens via Facile Dopamine Self-Polymerization for Posterior Capsular Opacification Prevention

Contact Info

Product

Resources

About