Utilizing cross-species co-cultures for discovery of novel natural products

Zhuang, Lei; Zhang, Haoran

doi:10.1016/j.copbio.2021.01.023

Cited by 28 publications

(30 citation statements)

References 59 publications

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“…It is therefore a convenient way to exploit the interactions of different species and stimulate individual strain cryptic genes and trigger the generation of new products. Yet, the exact biosynthetic mechanisms and pathways behind the overall process are complex and still await elucidation ( Maglangit et al, 2020 ; Zhuang and Zhang, 2021 ). To be successful, biosynthesis of new products in co-culture requires appropriate conditions for the compatible coexistence of the different microbial species involved ( Zhuang and Zhang, 2021 ).…”

Section: Laccasesmentioning

confidence: 99%

“…Yet, the exact biosynthetic mechanisms and pathways behind the overall process are complex and still await elucidation ( Maglangit et al, 2020 ; Zhuang and Zhang, 2021 ). To be successful, biosynthesis of new products in co-culture requires appropriate conditions for the compatible coexistence of the different microbial species involved ( Zhuang and Zhang, 2021 ). In terms of compatibility, different interactions have been highlighted between species in co-culture fermentations: one species develops at the expense of the others, the species inhibit each other (deadlock), or they collaborate ( Wiberth et al, 2019 ).…”

Section: Laccasesmentioning

confidence: 99%

See 1 more Smart Citation

Recent Developments in the Immobilization of Laccase on Carbonaceous Supports for Environmental Applications - A Critical Review

Adamian

Lonappan

Alokpa

et al. 2021

Front. Bioeng. Biotechnol.

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Τhe ligninolytic enzyme laccase has proved its potential for environmental applications. However, there is no documented industrial application of free laccase due to low stability, poor reusability, and high costs. Immobilization has been considered as a powerful technique to enhance laccase’s industrial potential. In this technology, appropriate support selection for laccase immobilization is a crucial step since the support could broadly affect the properties of the resulting catalyst system. Through the last decades, a large variety of inorganic, organic, and composite materials have been used in laccase immobilization. Among them, carbon-based materials have been explored as a support candidate for immobilization, due to their properties such as high porosity, high surface area, the existence of functional groups, and their highly aromatic structure. Carbon-based materials have also been used in culture media as supports, sources of nutrients, and inducers, for laccase production. This study aims to review the recent trends in laccase production, immobilization techniques, and essential support properties for enzyme immobilization. More specifically, this review analyzes and presents the significant benefits of carbon-based materials for their key role in laccase production and immobilization.

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Section: Laccasesmentioning

confidence: 99%

Section: Laccasesmentioning

confidence: 99%

Recent Developments in the Immobilization of Laccase on Carbonaceous Supports for Environmental Applications - A Critical Review

Adamian

Lonappan

Alokpa

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Accessing this latent reservoir of chemical diversity is therefore of high interest, and multiple strategies have been developed to tap into this resource. These strategies include genome mining approaches that rely on a wealth of genomic information ( 6 , 58 , 59 ), metagenome-guided biosynthesis ( 60 , 61 ), chemical profiling of microbial interactions (reviewed in references 28 and 62 ), enriching for likely producers based on intrinsic antimicrobial resistance ( 63 ), and harnessing compound libraries as elicitors of silent gene cluster activation (HiTES) ( 23 , 24 , 64 ). Each of these strategies has their own unique advantages (reviewed in references 2 , 24 , and 65 ).…”

Section: Discussionmentioning

confidence: 99%

Harnessing Rare Actinomycete Interactions and Intrinsic Antimicrobial Resistance Enables Discovery of an Unusual Metabolic Inhibitor

McClung

Antonich

et al. 2022

mBio

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“…Moreover, the co-cultivation approach may in some cases result in the enhanced levels of target products. Inducing and stimulating the production of secondary metabolites in microbial co-cultures is a topic that has been thoroughly reviewed (Arora et al 2020 ; Bertrand et al 2014 ; Chen et al 2020 ; Liu and Kakeya 2020 ; Zhuang and Zhang 2021 ), also in the context of the Streptomyces genus (Hoshino et al 2019 ; Kim et al 2021 ). However, the previous reviews were rather focused on the chemical spectrum of newly discovered or enhanced metabolites, not on the bioprocess-related aspects of co-cultivation.…”

Section: Introductionmentioning

confidence: 99%

A bioprocess perspective on the production of secondary metabolites by Streptomyces in submerged co-cultures

Boruta

2021

World J Microbiol Biotechnol

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Filamentous microorganisms are potent sources of bioactive secondary metabolites, the molecules formed in response to complex environmental signals. The chemical diversity encoded in microbial genomes is only partially revealed by following the standard microbiological approaches. Mimicking the natural stimuli through laboratory co-cultivation is one of the most effective methods of awakening the formation of high-value metabolic products. Whereas the biosynthetic outcomes of co-cultures are reviewed extensively, the bioprocess aspects of such efforts are often overlooked. The aim of the present review is to discuss the submerged co-cultivation strategies used for triggering and enhancing secondary metabolites production in Streptomyces, a heavily investigated bacterial genus exhibiting an impressive repertoire of secondary metabolites, including a vast array of antibiotics. The previously published studies on influencing the biosynthetic capabilities of Streptomyces through co-cultivation are comparatively analyzed in the bioprocess perspective, mainly with the focus on the approaches of co-culture initiation, the experimental setup, the design of experimental controls and the ways of influencing the outcomes of co-cultivation processes. These topics are discussed in the general context of secondary metabolites production in submerged microbial co-cultures by referring to the Streptomyces-related studies as illustrative examples.

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Utilizing cross-species co-cultures for discovery of novel natural products

Cited by 28 publications

References 59 publications

Recent Developments in the Immobilization of Laccase on Carbonaceous Supports for Environmental Applications - A Critical Review

Recent Developments in the Immobilization of Laccase on Carbonaceous Supports for Environmental Applications - A Critical Review

Harnessing Rare Actinomycete Interactions and Intrinsic Antimicrobial Resistance Enables Discovery of an Unusual Metabolic Inhibitor

A bioprocess perspective on the production of secondary metabolites by Streptomyces in submerged co-cultures

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