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Cited by 52 publications
(21 citation statements)
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“…EI-mass spectra were recorded on a VG Biotech Quattro 5022 spectrometer. 1H-NMR spectra were recorded on a Bruker AMX-500 in CDCl 3 and chemical shifts are given in ppm with TMS as internal standard .Silica gel was used for CC and silica gel 60 F-254 for TLC preparation. TLC optical rotations were measured using a Jasco DIP -370 Polarimeter in CHCl 3 .…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…EI-mass spectra were recorded on a VG Biotech Quattro 5022 spectrometer. 1H-NMR spectra were recorded on a Bruker AMX-500 in CDCl 3 and chemical shifts are given in ppm with TMS as internal standard .Silica gel was used for CC and silica gel 60 F-254 for TLC preparation. TLC optical rotations were measured using a Jasco DIP -370 Polarimeter in CHCl 3 .…”
Section: Methodsmentioning
confidence: 99%
“…Many hydrazine derivatives are known to exhibit significant biological activity and several compounds with hydrazine moiety were shown to be effective for treatment of tuberculosis, Parkinson's disease and hypertension 1 .Hydrazines shows neuroprotective, antitumor antidepressant and antimicrobial properties 2,3,4,5 .…”
Section: Introductionmentioning
confidence: 99%
“…However, cyclisation in the case of phenylhydrazine 2 occurs to the cyano group (thus producing a 5-amino-4-acetylpyrazole) while with pentafluorophenylhydrazine 3 the cyclisation is to the acetyl group (producing the 5-methyl-4-cyanopyrazole derivative 7e) 5 . Another interesting fact is that, in the case of the reaction of 1e with 3 we were able to isolate the intermediate enehydrazine 4e and on the basis of 1 H NMR analysis (two different doublets) to establish that the first nucleophilic attack was through the terminal (primary) amino group of the pentafluorophenylhydrazine 3 (route a) and therefore the succeeding cyclisation should produce 6 or 7 and not 8 or 9.…”
Section: Reactivity Of Pentafluorophenylhydrazinementioning
confidence: 99%
“…3 In the case of two non-equivalent electron withdrawing groups ('unsymmetrical enol ethers') cyclisation can give rise to two isomeric products and when a monosubstituted hydrazine is used the number of final products is theoretically doubled and indeed, in some cases all four possible products have been isolated (Scheme 1). [4][5][6] 2: Ar = C6H5, 3 -9: Ar = C6F5 X, Y, X′, Y′ for 1, 4 -9 (OH or NH2 can exist also in their tautomeric forms 7,8 Recently we studied the reaction of pentafluorophenylhydrazine with 2-ethoxymethylene-3-oxobutanenitrile and isolated an intermediate enehydrazine (2-pentafluorophenylhydrazinylmethylene-3-oxobutanenitrile) due to the lower nucleophilicity of the second nitrogen in comparison with phenylhydrazine 5 (route a). In continuation we have now studied the reaction of the monosubstituted hydrazine (pentafluorophenylhydrazine 3) with enolethers 1a-d,f-i and the chemoselectivity of the cyclisation reaction in the case of 'unsymmetrical' enol ethers 1f-i.…”
Section: Introductionmentioning
confidence: 99%
“…These compounds were screened for antibacterial and cytotoxic activities in vitro. 26 The strongest biological activity was found for 4-amino-3-acetylquinoline (AAQ). The effect of AAQ on cell proliferation of leukemia cells has not been reported previously, nor has its mechanism of cell death induction.…”
Section: Introductionmentioning
confidence: 99%