Utility of gray-scale ultrasound to differentiate benign from malignant thyroid nodules

Popli, Manju Bala; Rastogi, Ashita; Bhalla, Pjs; Solanki, Yachna

doi:10.4103/0971-3026.95407

Cited by 34 publications

(27 citation statements)

References 13 publications

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“…Sensitivity of US in detecting thyroid malignancy in the present study was 83.3% which was similar to a study of 203 patients from September 2009 to August 2010 where the overall sensitivity of thyroid US for diagnosing a malignant nodule was 81.8%. 22 Among cervical lymphadenopathy, out of 8 malignant lymph nodes, US correctly diagnosed 7. Out of these, 7 were metastatic lymph nodes and 1 was Hodgkin's lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of efficacy of Ultrasound in diagnosis of Neck Swellings

Rastogi

Sharma

Gauba

2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Neck swellings are a common cause of dilemma to clinicians. Accurate diagnosis of neck swellings is of paramount importance. This study evaluated patients with neck swellings to study their ultrasonographic features and correlated the ultrasound findings with the final diagnosis.Methods: 100 patients with neck swellings were evaluated clinically and divided into four groups– congenital, inflammatory, benign and malignant. Thereafter, they underwent high-resolution Ultrasound (US) and the ultrasonographic features of each type of swelling were studied. A final diagnosis was established after further evaluation using FNAC, further imaging, surgical intervention in the form of incision and drainage or excision/incisional biopsy with histopathological examination or successful non-surgical treatment. Ultrasound findings were compared with final diagnosis. Results: For swellings of inflammatory nature, this study showed the sensitivity, specificity, PPV and NPV of US to be 87.2%, 96.6%, 94.4%, 91.9% respectively. For benign swellings, sensitivity, specificity, PPV and NPV was 97.5%, 91.3%, 88.6% and 98.1% respectively. Sensitivity of US in diagnosing malignant lesions of the neck was 87.5% with a specificity of 98.7%, PPV 93.3% and NPV 97.5%. Sensitivity of US in detecting thyroid malignancy in the present study was 83.3% and in diagnosing malignant lymph nodes was 87.5%.Conclusions: Ultrasound is the ideal modality for initial imaging for neck swellings. Later on, as per the need and Ultrasound findings, one can go in for further haematological investigations, Fine Needle Aspiration Cytology and Radiological investigations.

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Section: Discussionmentioning

confidence: 99%

Evaluation of efficacy of Ultrasound in diagnosis of Neck Swellings

Rastogi

Sharma

Gauba

2017

Int J Otorhinolaryngol Head Neck Surg

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“…Similar findings (sensitivity and specificity of 65.9% and 87.2% respectively) were reported in another study. 1 We also found that hypoechogenicity had a high negative predictive value of 98.8% indicating that nodules which were not hypoechoic are likely to be malignant in only 4.2% of cases. We observed that US feature of microcalcification had a high specificity (96.5 %) and less sensitivity (16.6%).…”

Section: Resultsmentioning

confidence: 78%

“…Many sonological features like irregular margins, micro calcifications, taller than wider shape, marked hypoechogenicity have been shown to have predilection for malignancy. [1][2][3][4][5][6][7] However, there is also overlap in the appearance of benign and malignant t hyroid nodules. Due to inconsistent predictive value of USG features, fine needle aspiration and cytopathological…”

Section: Introductionmentioning

confidence: 99%

Application of society of radiologists in ultrasound recommendations for fine needle aspiration of thyroid nodules

et al. 2017

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Background: The Society of Radiologists in Ultrasound (SRU) recommendations on thyroid nodules are intended to "diagnose thyroid cancers that have reached clinical significance,while avoiding unnecessary tests and surgery in patients with benign nodules."Methods: This prospective observational study was conducted on 193 consecutive patients undergoing ultrasonography (USG) guided thyroid FNA. Nodules were categorized as "SRU-positive"and "SRU-negative" based on USG features. The sensitivity and specificity of the SRU recommendations and of various US features for thyroid malignancy were calculated.Results: Of 193 patients subjected to FNA, 83 patients of Bethesda class I,III,IV,V were excluded. Among 110 nodules subjected to FNA, 79 were SRU positive and 31were SRU negative. There were 24 malignancies in 110 FNA (22% malignancy prevelance). There was significant difference between the malignancy rates of SRU positive and negative groups (p=0.0192). The sensitivity, specificity, PPV, NPV of thyroid malignancy in our cohort was 91.6%, 33.7%, 27.8% and 93.5% respectively. Conclusions:The application of SRU recommendations reduces the number of benign nodules that undergo workup. Potentially missed malignancies in SRU negative nodules are less aggressive by histologic type and stage compared to SRU-positive malignancies.

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“…Tiroid nodüllerinin tespitinde fizik muayene önemlidir ve yapılan klinik çalışmalarda, dikkatli bir muayene ile toplumun %3-7 sinde nodül tespit edilebileceği gösterilmiştir (8). Türkiye'de yapılan çalışmalarda, bu oran yaklaşık %2,8 olarak bulunmuştur (9).…”

Section: Discussionunclassified

Relationship Between Thyroid Nodule Diameter and Malignancy: Does Nodule Diameter Actually Increase Probability of Malignancy?

Er¹,

Akın²,

Baba³

et al. 2017

Akd Med J

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ÖZAmaç: Tiroid nodülleri tiroid glandının en önemli patolojilerindendir. Tiroid nodüllerinde, bazı özel-liklerin bulunması nodülün malign olma olasılığını artırmaktadır. Çalışmamızda, bu parametrelerden özellikle nodül çapının malignite ile olan ilişkisini ve ek olarak bunun yanında ultrasonografi de karşılaş-tığımız diğer risk faktörlerinin malignite açısından destekleyici özelliklerini incelemeyi amaçladık. Gereç ve Yöntemler: Çalışma Ankara Numune Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği'nde 2006-2012 yılları arasında opere edilen toplam 271 olgu üzerinde yapılmıştır. Olgular; yaş, cinsiyet, USG ( nodül boyutu, yapısı, sayısı, ekojenitesi, kontur özellikleri, kalsifikasyon durumu) bulgularına ve İİAB sonuçlarına göre değerlendirildi. Bulgular: Çalışmaya dahil edilen 271 hastanın, 227'si(%83,8) kadın, 44'ü(%16) erkekti. Hastaların yaş ortalaması 49,2 ± 13 idi. Tek nodül çapı ile malignite arası değerlendirme yapıldığında; hastaların nodül çapı ile postoperatif sonuç arasında anlamlı bir ilişki olduğu görüldü (p=0,001). Benign nodüller içerisinde çapı 1 cm'den az olanların oranı daha az iken, malign nodüller içerisinde ise çapı 1 cm'den az olanların oranı daha fazla tespit edildi. Multinodüler grupta ise malignite ve çap arasındaki ilişki anlamlı bulunmadı (p=0,679). Sonuç: Nodül çapı ile malignite arasında anlamlı bir ilişki mevcut olup, bu ilişki soliter nodüllerde daha anlamlı olmakla beraber, küçük çaplı nodüller daha malign bulunmuştur. Nodül çapı tiroid nodül takibinde önemlidir ancak, benign-malign ayrımında tek başına çok anlam ifade etmemektedir. Anahtar Sözcükler: Tiroid nodülü, Tiroid kanseri, Nodül çapı-malignite ilişkisi ABSTRACT Objective: Thyroid nodules are the most important pathologies of the thyroid gland. The presence of certain features in thyroid nodules increases the likelihood that the nodule is malignant. In our study, we aimed to investigate the relationship between malignancy and nodule diameter, and other risk factors that we encountered on ultrasonography (USG) in terms of malignancy. Material and Methods: This study was carried out on 271 cases operated between 2006 and 2012 at the Clinic of General Surgery, Ankara Numune Training and Research Hospital. Features such as age, gender, USG (nodule size, structure, number, echogenicity, contour features, calcification status) were evaluated according to the findings and the results of fine needle aspiration biopsy (FNAB). Results: Of the 271 patients included in the study, 227 (83.8%) were female and 44 (16%) were male. The mean age for all groups was 49.2 ± 13. When single nodule diameter and malignancy were evaluated, there was a significant correlation between nodule diameter and post-operative outcome of the patients (p = 0.001). The proportion of nodules with a diameter less than 1 cm was lower in benign nodules while nodules with a diameter less than 1 cm were more common among malignant nodules. In the multinodular group, the relationship between malignancy and diameter was not significant (p = 0.679). Conclusion: The...

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Utility of gray-scale ultrasound to differentiate benign from malignant thyroid nodules

Cited by 34 publications

References 13 publications

Evaluation of efficacy of Ultrasound in diagnosis of Neck Swellings

Evaluation of efficacy of Ultrasound in diagnosis of Neck Swellings

Application of society of radiologists in ultrasound recommendations for fine needle aspiration of thyroid nodules

Relationship Between Thyroid Nodule Diameter and Malignancy: Does Nodule Diameter Actually Increase Probability of Malignancy?

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