Utility of flow cytometry in subtyping composite and sequential lymphoma

Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study

“…Among the 49 patients with multiple lymphomas, five (10.2%) were composite/discordant lymphomas (Table 1), of those, four were "composite lymphoma" (Kim 1993) with a combination of DLBCL and ATL or other T-cell lymphoma in a single tissue, and the rest one was "discordant lymphoma" (Acker et al 1983) with a combination of FL in the spleen and Waldenström macroglobulinemia in the bone marrow. The remaining 44 patients (89.8%) were "sequential lymphoma" (Siebert et al 1999) of various combinations of lymphoma types on different dates (Tables 2 and 3). The frequent combination of the first/second types of lymphoma were MZL/DLBCL (n = 4), DLBCL/ATL (n = 3), and WM or LPL/DLBCL (n = 3).…”

Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study

“…Among the 49 patients with multiple lymphomas, five (10.2%) were composite/discordant lymphomas (Table 1), of those, four were "composite lymphoma" (Kim 1993) with a combination of DLBCL and ATL or other T-cell lymphoma in a single tissue, and the rest one was "discordant lymphoma" (Acker et al 1983) with a combination of FL in the spleen and Waldenström macroglobulinemia in the bone marrow. The remaining 44 patients (89.8%) were "sequential lymphoma" (Siebert et al 1999) of various combinations of lymphoma types on different dates (Tables 2 and 3). The frequent combination of the first/second types of lymphoma were MZL/DLBCL (n = 4), DLBCL/ATL (n = 3), and WM or LPL/DLBCL (n = 3).…”

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma Are Biclonal Lymphomas

“…6,12 As illustrated in case 1, the absence of immunoglobulin expression of the FL population and the lack of detectable CD5 in the CLL population can potentially result in the diagnostic pitfall of interpreting the flow cytometry data as a single B-cell population with partial CD10, sIgλCD20, and CD23 expression. However, the exclusion between surface immunoglobulin λ and CD10 and the almost total lack of coexpression between CD20 (moderate intensity) and CD23 should raise the suspicion of a second neoplastic B-cell population.…”

Immunophenotyping of selected hematologic disorders – focus on lymphoproliferative disorders with more than one malignant cell population

“…Several case reports of biclonal or composite B‐cell lymphomas have been published . The reported overall incidence of B‐cell chronic LPDs presenting with more than one aberrant population in one larger series ( n = 477) studied by FCM was approximately 5% .…”

Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study

“…Among the 49 patients with multiple lymphomas, five (10.2%) were composite/discordant lymphomas (Table 1), of those, four were "composite lymphoma" (Kim 1993) with a combination of DLBCL and ATL or other T-cell lymphoma in a single tissue, and the rest one was "discordant lymphoma" (Acker et al 1983) with a combination of FL in the spleen and Waldenström macroglobulinemia in the bone marrow. The remaining 44 patients (89.8%) were "sequential lymphoma" (Siebert et al 1999) of various combinations of lymphoma types on different dates (Tables 2 and 3). The frequent combination of the first/second types of lymphoma were MZL/DLBCL (n = 4), DLBCL/ATL (n = 3), and WM or LPL/DLBCL (n = 3).…”

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma Are Biclonal Lymphomas

“…6,12 As illustrated in case 1, the absence of immunoglobulin expression of the FL population and the lack of detectable CD5 in the CLL population can potentially result in the diagnostic pitfall of interpreting the flow cytometry data as a single B-cell population with partial CD10, sIgλCD20, and CD23 expression. However, the exclusion between surface immunoglobulin λ and CD10 and the almost total lack of coexpression between CD20 (moderate intensity) and CD23 should raise the suspicion of a second neoplastic B-cell population.…”

Immunophenotyping of selected hematologic disorders – focus on lymphoproliferative disorders with more than one malignant cell population

“…Several case reports of biclonal or composite B‐cell lymphomas have been published . The reported overall incidence of B‐cell chronic LPDs presenting with more than one aberrant population in one larger series ( n = 477) studied by FCM was approximately 5% .…”

Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study

“…Among the 49 patients with multiple lymphomas, five (10.2%) were composite/discordant lymphomas (Table 1), of those, four were "composite lymphoma" (Kim 1993) with a combination of DLBCL and ATL or other T-cell lymphoma in a single tissue, and the rest one was "discordant lymphoma" (Acker et al 1983) with a combination of FL in the spleen and Waldenström macroglobulinemia in the bone marrow. The remaining 44 patients (89.8%) were "sequential lymphoma" (Siebert et al 1999) of various combinations of lymphoma types on different dates (Tables 2 and 3). The frequent combination of the first/second types of lymphoma were MZL/DLBCL (n = 4), DLBCL/ATL (n = 3), and WM or LPL/DLBCL (n = 3).…”

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma Are Biclonal Lymphomas

“…6,12 As illustrated in case 1, the absence of immunoglobulin expression of the FL population and the lack of detectable CD5 in the CLL population can potentially result in the diagnostic pitfall of interpreting the flow cytometry data as a single B-cell population with partial CD10, sIgλCD20, and CD23 expression. However, the exclusion between surface immunoglobulin λ and CD10 and the almost total lack of coexpression between CD20 (moderate intensity) and CD23 should raise the suspicion of a second neoplastic B-cell population.…”

Immunophenotyping of selected hematologic disorders – focus on lymphoproliferative disorders with more than one malignant cell population

“…Several case reports of biclonal or composite B‐cell lymphomas have been published . The reported overall incidence of B‐cell chronic LPDs presenting with more than one aberrant population in one larger series ( n = 477) studied by FCM was approximately 5% .…”