Utilidad de los índices neutrófilo/linfocito, monocito/linfocito y linfocito/plaqueta para el pronóstico de complicaciones asociadas a COVID-19

Ramos-Peñafiel, Christian Omar; Santos-González, Brenda; Flores-López, Eder N; Galván-Flores, Francisco; Hernández-Vázquez, Lucía; Santoyo-Sánchez, Adrián; Oca-Yemha, Rosaura Montes de; Bejarano-Rosales, Mónica; Rosas-Gonzalez, Erika Areli; Olarte-Carrillo, Irma; Martínez-Murillo, Carlos; Martínez-Tovar, Adolfo

doi:10.24875/gmm.20000458

Cited by 5 publications

(18 citation statements)

References 21 publications

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“…The RR for mortality in men younger than 60 years was not significant. However, the magnitude of the association was similar to that found in older subjects (1.53 vs 1.54), and this particular meta-analysis was based only on four studies (10,13,19,22), which probably lacks power to reach definitive conclusions in this subgroup.…”

Section: Resultssupporting

confidence: 60%

“…In this analysis, the magnitude of the association of male sex and COVID-19 severity was similar regardless of age group: the group of patients o50 years old had an RR of 1.37 (95%CI: 1.01 to 1.86; I 2 44%, P for heterogeneity 0.06; 11 studies), the group of patients aged 51-60 years had an RR of 1.32 (95%CI: 1.11 to 1.56; I 2 57%, P for heterogeneity o0.01, 18 studies), and the group of patients aged 460 years had a RR of 1.24 (95%CI: 1.12 to 1.38; I 2 37%, P for heterogeneity 0.08, 14 studies). The quality assessment of the included studies is presented in Supplementary Tables S1 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) and S2 (9,10,12,14,15,19,, showing an overall good quality, and no publication bias was identified after inspection of the funnel plot (Supplementary Figure S1).…”

Section: Resultsmentioning

confidence: 99%

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Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age

Fabião

Sassi

Pedrollo

et al. 2022

Braz J Med Biol Res

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We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; I 2 63%, P for heterogeneity o0.01) compared to women. Age was not a significant covariate in meta-analysis heterogeneity (P=0.393) or subgroup analysis. For disease severity, being male was associated with a relative risk of 1.29 (95%CI: 1.19 to 1.40; I 2 48%, P for heterogeneity o0.01) compared to the relative risk of women. Again, age did not influence the outcomes of the metaregression (P=0.914) or subgroup analysis. Men had a higher risk of COVID-19 mortality and severity regardless of age, decreasing the odds of hormonal influences in the described outcomes.

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Section: Resultssupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age

Fabião

Sassi

Pedrollo

et al. 2022

Braz J Med Biol Res

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“… NLR reflects intensity of inflammation and also indicates a poor prognosis. Ramos-Penafiel et al 2020 67 Death n=54 Alive n=71 13.93 10.56 0.052 - - - - NLR can predicts SARS-CoV-2 infection-associated mortality. Kilercik et al 2021 80 Critical-survivors severe n=23 Critical non-survivors; death n=15 Non-critical mild n=59 Critical-survivors severe=6.2 Critical non-survivors; death=11.4 Non-critical Mild= 2.67 <0.001 3.1 - 54.1 87 NLR is the best time-related marker over the course of the disease, distinguishing non-critical patient group from non-survivor patient group after the 2th-4th day of admission NLR can be used as an indicator to distinguish critical patients from non-critical COVID-19 patients and to predict mortality from COVID-19.…”

Section: Introductionmentioning

confidence: 97%

“… PLR in COVID-19 can assist in the diagnosis of prediction of mortality. Ramos-Peñafiel et al 2020 67 Death n=54 0648 Alive n=71 419 338 0.192 - - - - PLR can predicts SARS-CoV-2 infection-associated mortality. PLR may be used in combination as indicators of the inflammatory and immunological status.…”

Section: Introductionmentioning

confidence: 97%

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Clinical Significance and Diagnostic Utility of NLR, LMR, PLR and SII in the Course of COVID-19: A Literature Review

Kosidło¹,

Wolszczak-Biedrzycka²,

Matowicka-Karna³

et al. 2023

JIR

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Nowadays, society is increasingly struggling with infectious diseases that are characterized by severe course and even death. Recently, the whole world has faced the greatest epidemiological threat, which is COVID-19 caused by SARS CoV-2 virus. SARS CoV-2 infection is often accompanied by severe inflammation, which can lead to the development of different complications. Consequently, clinicians need easily interpreted and effective markers of inflammation that can predict the efficacy of the treatment and patient prognosis. Inflammation is associated with changes in many biochemical and hematological parameters, including leukocyte counts and their populations. In COVID-19, changes in leukocytes count populations such as neutrophils, lymphocytes or monocytes are observed. The numerous research confirm that indicators like neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelets-to-lymphocyte ratio (PLR) and systemic inflammatory index (SII) may prove effective in assessment patient prognosis and choosing optimal therapy. Therefore, in this review, we would like to summarize the latest knowledge about the diagnostic utility of systemic inflammatory ratios – NLR, LMR, PLR and SII in patients with COVID-19. We focused on the papers evaluating the diagnostic utility of inflammatory ratios using ROC curve published in the recent 3 years. Identification of biomarkers associated with inflammation would help the selection of patients with severe course of COVID-19 and high risk of death.

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Post-chemotherapy Cardiotoxicity in Women With Breast Cancer

Maldonado-Vega,

Cejudo-Arteaga,

Ramirez-Reyes

et al. 2023

Preprint

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Chemotherapy (CT) with anthracyclines can generate cardiotoxicity. The immunological system is part of the response to treatment with CT. Objective. Women with breast cancer were evaluated during their CT treatment, assessing their response to cardiotoxicity according to the treatment regimens and the classification of the cancer. Methods. Single CT and combined CT groups were made up (anthracyclines, Trastuzumab, and taxanes). Cardiotoxicity was measured as the Left Ventricle Expulsion Function (LVEF). The hematological response was measured at the end of treatment as the Lymphocyte/Macrophage Index (L/M) and the Lymphocyte/Platelet Index (L/P) The study included 451 women with breast cancer, among whom 230 underwent follow-up with LVEF on at least three occasions. Eight study groups were conformed based on their CT treatment. The comparison with LVEF was obtained between the baseline and the last LVEF. Results. Combined CT diminished the LVEF, contrary to the CT of a single compound, which in addition showed a recovery from LVEF. The combined CT caused functional loss in terms of LVEF in 27% of the studied population. The L/MI increased, and the L/PI diminished in patients with the combined therapy. This suggests the participation of inflammation processes and vascular damage. Human epidermal growth factor receptor 2positive (HER2+) and triple- negative patients have less survival, above all when the LVEF baseline was <55%. Conclusions. Anthracycline CT combined with other CT reduced the LVEF in women with breast cancer due to cardiotoxicity associated LVEF dysfunction. The use of only taxanes exerted a poor cardiotoxicity effect.

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Utilidad de los índices neutrófilo/linfocito, monocito/linfocito y linfocito/plaqueta para el pronóstico de complicaciones asociadas a COVID-19

Cited by 5 publications

References 21 publications

Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age

Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age

Clinical Significance and Diagnostic Utility of NLR, LMR, PLR and SII in the Course of COVID-19: A Literature Review

Post-chemotherapy Cardiotoxicity in Women With Breast Cancer

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