Uterine Fibrosarcoma in a Warmblood Mare

Govaere, Jan; Maes, S.; Saey, Veronique; Blancke, W; Hoogewijs, Maarten; Deschauwer, C; Smits, Katrien; Roels, K.; Vercauteren, Griet; Kruif, Aart de

doi:10.1111/j.1439-0531.2010.01694.x

Cited by 11 publications

(14 citation statements)

References 13 publications

(16 reference statements)

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“…Primary fibrosarcomas of the intestine itself are extremely rare in dogs and other animal species (Goldschmidt and Hendrick 2002), and may originate anywhere in the body (Orr 1984;Mahler et al 2006;Speltz et al 2007;Govaere et al 2010). To the authors' knowledge, to date only one case has been reported in the veterinary literature, in which a tumour was described in a 17-year old Cocker Spaniel (Hurov 1962).…”

Section: Discussionmentioning

confidence: 91%

“…The skin and subcutis are the primary sites of occurrence of fibrosarcomas in dogs and other domestic animals (Goldschmidt and Hendrick 2002), but these can develop anywhere in the body such as the heart (Speltz et al 2007), liver (Gallati 1956), kidney (Brown et al 1975), urinary bladder (Olausson et al 2005), uterus (Govaere et al 2010), omentum (Rayner et al 2010), trachea (Mahler et al 2006) and, on rare occasions, in the mammary gland (Orr 1984). Primary malignant intestinal tumours are rare in dogs, and they may cause clinical signs of luminal obstruction, intestinal dysfunction and intestinal ulceration and/or perforation, resulting in septic peritonitis (Larock and Ginn 1997;Head et al 2002).…”

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confidence: 99%

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Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Avcı¹,

Yaygingül²,

Gültekin³

et al. 2012

Vet. Med. - Czech

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An 11-year-old male Cocker Spaniel was examined for a palpable abdominal mass located in the jejunum after presenting with a history of anorexia and constipation for several weeks. In a contrast radiogram, a structure with well-defined borders adjacent to the intestine was determined. The intestinal mass, measuring 16 × 9.19 × 8.6 cm and weighing 900 g was surgically removed. At gross examination, when the lumen of a portion of the intestine excised together with the tumour mass was exposed, an ulcerated, oval-shaped area 1.2 × 0.6 cm in size was observed on the mucosa. The outer surface of the tumour was homogenous and expanded outwards from the intestinal wall. Histologically, the tumour was composed of fusiform-elongated spindle-shaped to polygonal neoplastic cells forming interlacing fascicles or interwoven bundles in an atypical herringbone pattern. Immnunohistochemically, neoplastic cells stained intensely positive for vimentin, and negative for α-SMA, desmin, cyotokeratin (AE1/AE3), S-100 protein, glial fibrillary acidic protein, neuron specific enolase and synaptophsin. On the basis of the histopathological and immunohistochemical results, the tumour was diagnosed as a fibrosarcoma. The present report is a very rare description of fibrosarcoma of the dog intestine associated with intestinal perforation.

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Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Avcı¹,

Yaygingül²,

Gültekin³

et al. 2012

Vet. Med. - Czech

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“…In addition, an endometrial fibrosarcoma with invasion in the myometrium; tumor cell emboli in lymphatics; and metastases in lungs, liver, and spleen is described in an 18-year-old Warmblood mare [91]. Other published neoplasms with involvement of the endometrium are multicentric lymphosarcomas, i.e., T-cell lymphosarcoma in a 22-year-old pony mare [92] as well as B-cell lymphosarcomas in a 5-year-old Quarter horse mare [93] and an 8-year-old Thoroughbred mare [94].…”

Section: Endometrial Cancer: a Rare Disease In Maresmentioning

confidence: 99%

The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses

Schöniger¹,

Schoon

2020

Animals

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Mares are seasonally polyestric. The breeding season in spring and summer and the winter anestrus are flanked by transitional periods. Endometrial diseases are a frequent cause of subfertility and have an economic impact on the horse breeding industry. They include different forms of endometrosis, endometritis, glandular maldifferentiation, and angiosis. Except for suppurative endometritis, these are subclinical and can only be diagnosed by the microscopic examination of an endometrial biopsy. Endometrosis is characterized by periglandular fibrosis and nonsuppurative endometritis by stromal infiltration with lymphocytes and plasma cells. The pathogenesis of endometrosis and nonsuppurative endometritis is still undetermined. Some mares are predisposed to persistent endometritis; this has likely a multifactorial etiology. Glandular differentiation has to be interpreted under consideration of the season. The presence of endometrial diseases is associated with alterations in the expression of several intra- and extracellular molecular markers. Some of them may have potential to be used as diagnostic biomarkers for equine endometrial health and disease. The aim of this review is to provide an overview on pathomorphological findings of equine endometrial diseases, to outline data on analyses of cellular and molecular mechanisms, and to discuss the impact of these data on reproduction and treatment.

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“…Leiomyoma, a benign neoplasia arising from the outer smooth muscle of the uterus, seems to be the most frequently occurring uterine tumor in mares (Van Camp, 1993). Several other tumors have sporadically been described affecting either the endometrium: fi broma (Estrada et al, 2008), fi brosarcoma (Govaere et al, 2011), adenocarcinoma (Gunson et al, 1980) and lymphosarcoma (Sweeney et al, 1991) or the myometrium: leiomyosarcoma (Lofstedt et al, 1987), fi broleiomyoma (Broome et al, 1992), and rhabdomyosarcoma (Torbeck et al, 1980). There is only one report on oviductal neoplasia (adenoma) in a mare (McEntee and Nielsen, 1976).…”

Section: Introductionmentioning

confidence: 99%

“…Benign masses which interfere with fertility may be removed. Malignant neoplasia are usually not treated since the prognosis is generally poor (Neufeld, 1973, Torbeck et al, 1980, Govaere et al, 2011.…”

Section: Introductionmentioning

confidence: 99%

Leiomyomata van salpinx en baarmoeder bij merries

Nelis¹,

Leemans²,

Vries³

et al. 2013

Vlaams Diergeneeskundig Tijdschrift

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This paper describes a case of a sessile uterine leiomyoma in a 17-year-old chronic infertileSelle Français mare. The mass was removed by transendoscopic electrocoagulation. In the sameperiod, 725 mares were screened for oviductal and uterine solid masses in a slaughterhouse survey.Two uterine masses and one oviductal mass were detected in three different mares. Histologicaland immunohistochemical examination revealed leiomyoma in the four masses. To the authors’knowledge, this is the fi rst report of an oviductal leiomyoma in a mare.

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Uterine Fibrosarcoma in a Warmblood Mare

Cited by 11 publications

References 13 publications

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses

Leiomyomata van salpinx en baarmoeder bij merries

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