3D holographic azimuthal electromagnetic resistivity logging while drilling is a convenient and efficient technology to obtain information about formation. It has the advantages of instant, accurate. It can be applied to the field of engineering such as evaluating the anisotropy and detecting nearby geological interfaces. A 3D electromagnetic resistivity azimuthal LWD instrument consists of coaxial, coplanar, tilted, and orthogonal antenna systems, being able to solve for all nine components. The explicit generic formulation is derived from presenting the response for a basic unit of one arbitrarily-oriented transmitter and one arbitrarily-oriented receiver. Combining the responses of basic units with different transmitter-receiver spacing and different components, an ‘anisotropy signal’ is defined with the phase difference${M_{px}}$ and amplitude ratio ${M_{ax}}$. A ‘boundary signal’ is also defined with the phase difference ${M_{pz}}$ and amplitude ratio ${M_{az}}$. Forward simulation results show that the 2MHz ${M_{px}}$ can accurately identify geological anisotropy in highly deviated and horizontal wells. The ${M_{az}}$can detect geological interfaces in highly deviated and horizontal wells. the 100KHz${\rm{\,\,}}{M_{az}}\,\,$can detect geological boundaries in the range of 8m-9m.