Using the Expression of Damage-Associated Molecular Pattern (DAMP) for the Evaluation and Monitoring of the Critically Ill Polytrauma Patient

Păpurică, Marius; Rogobete, Alexandru Florin; Săndesc, Dorel; Cradigati, Carmen Alina; Sărăndan, Mirela; Dumache, Raluca; Horhat, Florin George; Bratu, Lavinia Melania; Niţu, Răzvan; Crişan, Dan; Horhat, Delia Ioana; Popovici, Elena S; Tănăsescu, Sonia; Daliborca, Vlad; Borugă, Ovidiu; Bedreag, Ovidiu Horea

doi:10.7754/clin.lab.2016.160226

Cited by 4 publications

(5 citation statements)

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“…This reaction takes place only if it is catalyzed by the DiGeorge Syndrome Critical Region 8 (DGCR8). [43][44][45][46] The transporting protein, Exportin 5, will then act on the pre-miRNAs, which will transfer the epigenetic complex from the nucleus to the cell cytoplasm. [47][48][49] Once the signal that the complex has reached the cytoplasm is received, RNA polymerase III (Dicer) and trans-activator RNA binding protein (TRBP) attack it and lead to the formation of mature miRNAs.…”

Section: The Most Common Molecular Mechanisms Involved In Cvdsmentioning

confidence: 99%

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Buzaș

Rogobete

Popovici

et al. 2018

Journal of Cardiovascular Emergencies

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Worldwide, cardiovascular diseases (CVDs) represent one of the main causes of morbidity and mortality, and acute coronary syndromes are responsible for a large number of sudden cardiac deaths. One of the main challenges that still exist in this area is represented by the early detection and targeted monitoring of the pathophysiology involved in CVDs. During the last couple of years, researchers have highlighted the importance of molecular and epigenetic mechanisms involved in the initiation and augmentation of CVDs, culminating in their most severe form represented by acute myocardial infarction. One of the most studied molecular factors involved in this type of pathology is represented by nuclear transcription factor kappa B (NF-κB), as well as the involvement of microRNAs (miRNAs). It has been suggested that miRNAs can also be involved in the complex process of atheromatous plaque vulnerabilization that leads to an acute cardiac event. In this review paper, we describe the most important molecular mechanisms involved in the pathogenesis of CVDs and atheromatous plaque progression and vulnerabilization, which include molecular mechanisms dependent on NF-κB. For this paper, we used international databases (PubMed and Scopus). The keywords used for the search were “miRNAs biomarkers”, “miRNAs in cardiovascular disease”, “NF-κB in cardiovascular disease”, “molecular mechanism in cardiovascular disease”, and “myocardial NF-κB mechanisms”. Numerous molecular reactions that have NF-κB as a trigger are involved in the pathogenesis of CVDs. Moreover, miRNAs play an important role in initiating and aggravating certain segments of CVDs. Therefore, miRNAs can be used as biomarkers for early evaluation of CVDs. Furthermore, in the future, miRNAs could be used as a targeted molecular therapy in order to block certain mechanisms responsible for inducing CVDs and leading to acute cardiovascular events.

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Section: The Most Common Molecular Mechanisms Involved In Cvdsmentioning

confidence: 99%

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Buzaș

Rogobete

Popovici

et al. 2018

Journal of Cardiovascular Emergencies

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“…From a pathophysiological and molecular point of view, hypermetabolism is represented by a complex line of interconnected biochemical reactions that have disastrous effects on the clinical outcome. This is a very serious situation not only because of the hypermetabolism characterizing the critical period of these patients but also by the fact that this hypermetabolic status can continue years after the trauma, leading to a delayed recovery for these patients [58,[71][72][73]. The hypermetabolic status is characterized, in particular, by an alarming increase in oxygen consumption throughout the body.…”

Section: Biochemical and Pathophysiological Aspects Of The Hypermetabmentioning

confidence: 99%

Assessment of Metabolic and Nutritional Imbalance in Mechanically Ventilated Multiple Trauma Patients: From Molecular to Clinical Outcomes

et al. 2019

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The critically ill polytrauma patient is characterized by a series of metabolic changes induced by inflammation, oxidative stress, sepsis, and primary trauma, as well as associated secondary injuries associated. Metabolic and nutritional dysfunction in the critically ill patient is a complex series of imbalances of biochemical and genetic pathways, as well as the interconnection between them. Therefore, the equation changes in comparison to other critical patients or to healthy individuals, in which cases, mathematical equations can be successfully used to predict the energy requirements. Recent studies have shown that indirect calorimetry is one of the most accurate methods for determining the energy requirements in intubated and mechanically ventilated patients. Current research is oriented towards an individualized therapy depending on the energy consumption (kcal/day) of each patient that also takes into account the clinical dynamics. By using indirect calorimetry, one can measure, in real time, both oxygen consumption and carbon dioxide production. Energy requirements (kcal/day) and the respiratory quotient (RQ) can be determined in real time by integrating these dynamic parameters into electronic algorithms. In this manner, nutritional therapy becomes personalized and caters to the patients’ individual needs, helping patients receive the energy substrates they need at each clinically specific time of treatment.

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“…Critically ill polytrauma patients present one of the most complex clinical pictures that the intensivist and trauma team will encounter in their careers [1,2,3,4,5]. The complexity of these cases is due both to the initial traumatic injury, and to the secondary post-traumatic responses to injury [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16]. Moreover, through the interactions of molecular mechanisms with other, initially functional systems, and through molecular denaturation reactions, the critically ill polytrauma patient becomes a complex medical case from a clinical and molecular point of view.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Rogobete

Săndesc

Bedreag

et al. 2018

Cells

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A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Regarding the expression and activity of microRNAs in sepsis, their usefulness has reached new levels of significance. MicroRNAs can be used both as an early biomarker for sepsis, and as a therapeutic target because of their ability to block the complex reactions involved in the initiation, maintenance, and augmentation of the clinical status.

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Using the Expression of Damage-Associated Molecular Pattern (DAMP) for the Evaluation and Monitoring of the Critically Ill Polytrauma Patient

Abstract: Furthermore, evaluation, monitoring, and therapy adaptation in this type of patient is closely related to the biochemical and molecular disorders.

Cited by 4 publications

References 0 publications

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Assessment of Metabolic and Nutritional Imbalance in Mechanically Ventilated Multiple Trauma Patients: From Molecular to Clinical Outcomes

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

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