Using Remote Fields for Complex Tissue Engineering

Armstrong, James R.; Stevens, Molly M.

doi:10.1016/j.tibtech.2019.07.005

Cited by 72 publications

(51 citation statements)

References 60 publications

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“…Remote tissue engineering harnessing optical, acoustic and magnetic fields has attracted much attention in the last decades. Examples range from initiating cell differentiation or material degradation, to assembling components for tissue organization, aligning cell and matrix fibers [74]. The directed regeneration of aligned collagen fibers [75] and oriented neural cells requires only small magnetic fields [76], which can be provided by ferromagnetic liquid constructs.…”

Section: Technological Perspectivementioning

confidence: 99%

Perspective: Ferromagnetic Liquids

Streubel

Liu

et al. 2020

Materials

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Mechanical jamming of nanoparticles at liquid–liquid interfaces has evolved into a versatile approach to structure liquids with solid-state properties. Ferromagnetic liquids obtain their physical and magnetic properties, including a remanent magnetization that distinguishes them from ferrofluids, from the jamming of magnetic nanoparticles assembled at the interface between two distinct liquids to minimize surface tension. This perspective provides an overview of recent progress and discusses future directions, challenges and potential applications of jamming magnetic nanoparticles with regard to 3D nano-magnetism. We address the formation and characterization of curved magnetic geometries, and spin frustration between dipole-coupled nanostructures, and advance our understanding of particle jamming at liquid–liquid interfaces.

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Section: Technological Perspectivementioning

confidence: 99%

Perspective: Ferromagnetic Liquids

Streubel

Liu

et al. 2020

Materials

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“…The application of magnetic nanoparticles enables manipulation, handling, and rapid assembling of cell sheets into 3D tissue constructs. There are already several published well-written reviews describing label-based Mag-TE[ 15 - 17 ].…”

Section: Label-based Magnetic Tissue Engineeringmentioning

confidence: 99%

Scaffold-free, Label-free, and Nozzle-free Magnetic Levitational Bioassembler for Rapid Formative Biofabrication of 3D Tissues and Organs

Parfenov¹,

Petrov²,

Pereira³

et al. 2024

IJB

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Scaffolding is the conceptual framework of conventional tissue engineering. Over the past decade, scaffold-free approaches as a potential alternative to classic scaffold-based methods have emerged, and scaffold-free magnetic levitational tissue engineering (magnetic force-based tissue engineering [Mag-TE]) is a type of this novel tissue engineering strategy. However, Mag-TE is often based on the use of potentially toxic magnetic nanoparticles. Scaffold-free and label-free magnetic levitational bioassembly do not employ magnetic nanoparticles and thus, the potential toxicity of magnetic nanoparticles can be avoided. In this short review, we describe the conceptual foundation of scaffold-free, label-free, and nozzle-free formative biofabrication using magnetic fields as “scaffields.” The design and implementation of “Organ.Aut,” the first commercial magnetic levitational bioassembler, and the potential applications of magnetic bioassembler are discussed as well.

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“…The application of remote magnetic fields to hydrogels with magnetically responsive properties provides the liberty to control the 3D distribution and orientation of MNPs, which allows one not only to customize hydrogel’s internal architecture (reviewed below) but as well to remotely mechano-magnetically actuate the biomaterial. Actually, remote magnetic stimulation through magnetic responsive materials is emerging as one of the most interesting approaches to provide cells the adequate mechanical cues [ 157 , 158 ]. The effect of magneto-mechanical stimulation of neuron cells was analyzed using magnetic microparticles blended into high molecular weight hyaluronic acid hydrogels [ 159 ].…”

Section: Engineering Advanced Hydrogels For Tissue Engineering Appmentioning

confidence: 99%

Natural-Based Hydrogels for Tissue Engineering Applications

et al. 2020

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In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies.

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Using Remote Fields for Complex Tissue Engineering

Cited by 72 publications

References 60 publications

Perspective: Ferromagnetic Liquids

Perspective: Ferromagnetic Liquids

Scaffold-free, Label-free, and Nozzle-free Magnetic Levitational Bioassembler for Rapid Formative Biofabrication of 3D Tissues and Organs

Natural-Based Hydrogels for Tissue Engineering Applications

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