Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections

Abstract

Infections have accounted for the majority of failures in implants over the past decades. Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce drug resistance, and remarkable biocompatibility. In this review, covalent-grafting strategies are mainly discussed to tether host defense peptide mimicking polymers on surfaces, aiming to obtain potent antimicrobial activity. In addition to the antimicrobial function, we review the antimicrobial mechanism of these polymer-modified antimicrobial surfaces in precedent literatures. We also review the in vivo subcutaneous implant infection models that are critical assessments for potential biomedical applications. In the end, we provide our perspective on the future development of this field, especially for biomedical applications.

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A novel antibacterial gold nanoparticle layer with a self-cleaning ability through the production of oxygen bubbles

“…As one of the side effects, bacterial contamination of medical devices has caused serious consequences. [1][2][3] The results show that 75% of nosocomial urinary tract infections come from bacterial colonization on the surface of an indwelling catheter. 4 If left untreated, a urinary tract infection may further lead to kidney infection or septicemia, and even cause the death of patients in extreme cases.…”

Plasmonic photoreactors-coated plastic tubing as combined-active-and-passive antimicrobial flow sterilizer

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