PLoS ONE volume 9, issue 6, Pe98443 2014 DOI: 10.1371/journal.pone.0098443 View full text
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Susan J. Little, Sergei L. Kosakovsky Pond, Christy M. Anderson, Jason A. Young, Joel O. Wertheim, Sanjay R. Mehta, Susanne May, Davey M. Smith

Abstract: ObjectiveTo reconstruct the local HIV-1 transmission network from 1996 to 2011 and use network data to evaluate and guide efforts to interrupt transmission.DesignHIV-1 pol sequence data were analyzed to infer the local transmission network.MethodsWe analyzed HIV-1 pol sequence data to infer a partial local transmission network among 478 recently HIV-1 infected persons and 170 of their sexual and social contacts in San Diego, California. A transmission network score (TNS) was developed to estimate the risk of H…

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