Using High-Resolution 3D Magnetic Resonance Imaging to Quantitatively Analyze the Shape of Eyeballs with High Myopia and Provide Assistance for Posterior Scleral Reinforcement

Wen, Baohong; Yang, Ge; Cheng, Jingliang; Jin, Xuemin; Zhang, Huixia; Wang, Feifei; Yan, Chenyu; Zheng, Dandan; Xu, Tian-Yong

doi:10.1159/000477466

Cited by 16 publications

(11 citation statements)

References 30 publications

(29 reference statements)

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“…Intriguingly, although LT was not associated with myopia in a previous study [34], we detected a significant difference in LT between the high myopic group and the emmetropic group in this study and in another study using the IOLMaster 700 [17]. High myopic eyes are more susceptible to zonular failure [12,35]; therefore, we suspect that the reduction in LT with longer AL can be attributed in part to zonular weakness. Zonular failure may cause the lens to sink, which will affect the accurate measurement of LT.…”

Section: Discussioncontrasting

confidence: 47%

Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography

Lü

Qian

et al. 2020

Eye and Vis

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Background: To measure the crystalline lens tilt in eyes with various degrees of myopia before cataract surgery using swept-source optical coherence tomography (SS-OCT). Methods: We used SS-OCT (IOLMaster 700) to scan 131 emmetropic eyes (axial length < 24.5 mm), 25 mild/moderate myopic eyes (axial length 24.5-26 mm), and 123 high myopic eyes (52, 29, and 42 eyes with axial lengths of 26-28, 28-30, and > 30 mm, respectively) as part of the routine preoperative examination before cataract surgery. SS-OCT involved B-scans along six meridians. The data were analyzed to assess the magnitude and orientation of the lens tilt and their correlation with other optical biometric parameters. Result: The mean tilt was 3.36 ± 0.98°in emmetropic eyes, 3.07 ± 1.04°in mild/medium myopic eyes, and 2.35 ± 1.01°i n high myopic eyes. Tilt correlated significantly and inversely with axial length (Pearson's r = − 0.427, P < 0.001). The crystalline lens tilt predominantly faced the upper outer quadrant relative to the visual axis, symmetrically in both eyes, with mean angles of 24.32°and 147.36°in the right and left eyes, respectively. The variability in the lens tilt direction increased with increasing axial length (χ 2 test, P < 0.001). Conclusion:The magnitude of crystalline lens tilt decreased with increasing axial length. The direction of tilt was predominantly towards the upper outer quadrant in both eyes. The variability in the tilt orientation increased with increasing axial length. Trial registration: NIH (clinicaltrial.gov), NCT03062085. Registered 23 February 2017.

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Section: Discussioncontrasting

confidence: 47%

Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography

Lü

Qian

et al. 2020

Eye and Vis

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“…Khokhar et al suggested that the anterior and posterior segments of the eye with low myopia or ametropia were proportional to eye growth but disproportionate in high myopia (Khokhar et al, 2018). Research using 3D MRI of myopia morphology also found that the longitudinal and transverse diameter ratio of the eyeball was larger in high myopia than in non-high myopia (Wen et al, 2017). This suggested that the expansion of the eyeball was uneven in SEE as compared to MEE.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Axial Length Elongation on Corneal Biomechanical Property

Hua

Zhang

et al. 2021

Front. Bioeng. Biotechnol.

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Background: To investigate the correlation between the corneal biomechanical parameter stress-strain index (SSI) and axial length (AL) in moderately elongated eye (MEE) and severely elongated eye (SEE).Methods: This study included 117 eyes from 117 participants. Among them, 59 (50.4%) had MEE (AL<26 mm) and 58 (49.6%) had SEE (AL≥26 mm). AL was measured using Lenstar LS-900, and central corneal thickness (CCT) and anterior chamber volume (ACV) were measured using Pentacam. SSI was measured via corneal visualisation Scheimpflug technology (Corvis ST). Kolmogorov-Smirnov test, Student’s t-test, and Pearson and partial correlation analyses were used for statistical analyses.Results: The mean (±SD) SSI was 1.08 ± 0.15 in the MEE group and 0.92 ± 0.13 in the SEE group (p < 0.01). SSI was positively correlated with age (MEE: r = 0.326, p < 0.05; SEE: r = 0.298, p < 0.05) in both groups; it was negatively correlated with AL (r = −0.476, p < 0.001) in the MEE group but not in the SEE group (p > 0.05). CCT was negatively correlated with AL (r = −0.289, p < 0.05) and ACV positively correlated with AL (r = 0.444, p < 0.001) in the MEE group. Neither CCT nor ACV was correlated with AL (p > 0.05) in the SEE group.Conclusion: Corneal biomechanical parameter SSI, which represents the stiffness of corneal tissue, was lower in the SEE group than in the MEE group. When analyzed separately, SSI was negatively correlated with AL in the MEE group, but not in the SEE group, which may provide insight into different ocular growth patterns between lower myopia and higher myopia.

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“…The method for 3D MRI scanning has been described in our previous studies. 10 Briefly, a magnetic resonance scanner and 32-channel head coil were used while the patient was in a supine position. After closing the eyelid, the 3D sequence MRI scanning of the eye was applied.…”

Section: Methodsmentioning

confidence: 99%

Correlation Between Posterior Staphyloma and Dome-Shaped Macula in High Myopic Eyes

Dai

Wang

et al. 2019

Retina

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Using High-Resolution 3D Magnetic Resonance Imaging to Quantitatively Analyze the Shape of Eyeballs with High Myopia and Provide Assistance for Posterior Scleral Reinforcement

Cited by 16 publications

References 30 publications

Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography

Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography

The Effect of Axial Length Elongation on Corneal Biomechanical Property

Correlation Between Posterior Staphyloma and Dome-Shaped Macula in High Myopic Eyes

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