Using Global Metabolomics to Identify Novel Biomarkers of Treatment-Associated Cognitive Impairment in Pediatric Acute Lymphoblastic Leukemia

Abstract

A significance decrease in the incidence was only observed in Whites, but not in Blacks, Hispanics, or Asians/Pacific Islanders. A significance decrease was observed in the incidence of non-squamous cell carcinoma (SCC) rather than SCC among young females 15-24 years from 3 in 2007 to 1.5 in 2013 (APD 9.1, 95% CI 3.1-14.7). Conclusion: A significance decrease in the incidence of cervical cancer during the vaccine era among young females 15-24 years may indicate early effects of HPV vaccination. Further research is needed to confirm this trend.

Biomarkers of Cognitive Impairment in Pediatric Cancer Survivors

“…Agnostic approaches (eg, metabolomics, RNA-seq, etc) might identify additional unsuspected pathways that are altered by cancer therapy, yielding useful biomarkers. 76 Given that cancer-related neurocognitive impairment is multifactorial, it is likely that the pathologic pathways overlap in cooperative or antagonistic feedback loops. Neuroinflammation, for example, induces oxidative stress and downstream epigenetic changes and chromosomal instability resulting in telomere attrition.…”

“…Agnostic approaches (eg, metabolomics, RNA-seq, etc) might identify additional unsuspected pathways that are altered by cancer therapy, yielding useful biomarkers. 76…”