Using clinical and robotic assessment tools to examine the feasibility of pairing tDCS with upper extremity physical therapy in patients with stroke and TBI: A consideration-of-concept pilot study

Middleton, Addie; Fritz, Stacy L.; Liuzzo, Derek M.; Newman‐Norlund, Roger; Herter, Troy M.

doi:10.3233/nre-141178

Cited by 38 publications

(51 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Table 2 details seven tDCS studies. 39 – 45 Six clinical studies were found in the chronic phase of TBI, and there was only one study 39 in the subacute phase. In contrast to TMS studies, most tDCS studies were randomized controlled trials or crossover studies.…”

Section: Methodsmentioning

confidence: 99%

“…All patients received bihemispheric tDCS over M1 paired with standard upper extremity physical therapy (24 sessions of 40 minutes, three times per week). They monitored lasting motor function improvement 45 and reported positive results 6 months after tDCS stimulation.…”

Section: Methodsmentioning

confidence: 99%

“… 52 This enzymatic restoration improves cellular activity of brain tissue that has been damaged by TBI. 45 Thereby, transcranial LLLT may become a novel therapy to enhance cognitive performance; emotional functions; and neurological conditions 47 , 56 linked to mitochondrial dysfunction, 47 a ubiquitous finding in brain injury due to TBI.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence

Li¹,

Zaninotto²,

Neville³

et al. 2015

NDT

View full text Add to dashboard Cite

Traumatic brain injury (TBI) remains the main cause of disability and a major public health problem worldwide. This review focuses on the neurophysiology of TBI, and the rationale and current state of evidence of clinical application of brain stimulation to promote TBI recovery, particularly on consciousness, cognitive function, motor impairments, and psychiatric conditions. We discuss the mechanisms of different brain stimulation techniques including major noninvasive and invasive stimulations. Thus far, most noninvasive brain stimulation interventions have been nontargeted and focused on the chronic phase of recovery after TBI. In the acute stages, there is limited available evidence of the efficacy and safety of brain stimulation to improve functional outcomes. Comparing the studies across different techniques, transcranial direct current stimulation is the intervention that currently has the higher number of properly designed clinical trials, though total number is still small. We recognize the need for larger studies with target neuroplasticity modulation to fully explore the benefits of brain stimulation to effect TBI recovery during different stages of recovery.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence

Li¹,

Zaninotto²,

Neville³

et al. 2015

NDT

View full text Add to dashboard Cite

show abstract

“…There has been similar variability in the reports of combined rehabilitative training and tDCS in the injured population. Several studies have reported greater behavioral improvement with combined tDCS and training, compared with training alone, in motor function (Middleton et al, 2014 ; Kasashima-shindo et al, 2015 ), motor function associated electrophysiology measures (Kim and Ko, 2013 ), aphasia (Wu et al, 2015 ), neglect (single case report) (Brem et al, 2014 ), and attention (Park et al, 2013b ). However, some of the positive studies were conducted on extremely small numbers ( n < 10).…”

Section: Brain Lesions After Stroke and Injurymentioning

confidence: 99%

The contribution of interindividual factors to variability of response in transcranial direct current stimulation studies

Uehara

Hanakawa

2015

Front. Cell. Neurosci.

366

291

View full text Add to dashboard Cite

There has been an explosion of research using transcranial direct current stimulation (tDCS) for investigating and modulating human cognitive and motor function in healthy populations. It has also been used in many studies seeking to improve deficits in disease populations. With the slew of studies reporting “promising results” for everything from motor recovery after stroke to boosting memory function, one could be easily seduced by the idea of tDCS being the next panacea for all neurological ills. However, huge variability exists in the reported effects of tDCS, with great variability in the effect sizes and even contradictory results reported. In this review, we consider the interindividual factors that may contribute to this variability. In particular, we discuss the importance of baseline neuronal state and features, anatomy, age and the inherent variability in the injured brain. We additionally consider how interindividual variability affects the results of motor-evoked potential (MEP) testing with transcranial magnetic stimulation (TMS), which, in turn, can lead to apparent variability in response to tDCS in motor studies.

show abstract

“…Los métodos de evaluación del movimiento de la ES convencionales dependen de la experiencia y la subjetividad de los médicos o terapeutas evaluadores. Las evaluaciones de la función motora de la ES se centran en pruebas clínicas que dependen en gran medida de los criterios del examinador (Middleton et al, 2014) y requieren que un terapeuta califique a los pacientes mientras estos realizan tareas y actividades específicas.…”

Section: Introductionunclassified

Métodos para la evaluación motora objetiva de pacientes con daño cerebral adquirido en neurorrehabilitación funcional

Villán¹

View full text Add to dashboard Cite

Por último, pero no menos importante, gracias a mi esposo Jesús, por permitirme ser su compañera de vida, por ser el principal motivador de mi día a día, por su entrega y ayuda incondicional, por compartirme todos sus conocimientos, por su apoyo, por su paciencia, por su amor. Gracias Jesús, sin ti todo esto habría sido casi imposible.Hay bajo el sol un momento para todo, y un tiempo para hacer cada cosa: tiempo para plantar, y tiempo para cosechar. Eclesiastés 3, 1-2b. A DiosA Jesús, mi esposo A mis padres, hermana, sobrina y cuñado 3. Evaluación motora objetiva de la extremidad superior. Se diseña, desarrolla y valida la metodología de evaluación motora objetiva de los movimientos de la EFM de la ES realizados por pacientes con DCA. Esta metodología se basa en el cálculo de la puntuación de los parámetros de movimiento de los pacientes mediante el algoritmo implementado para este fin. Por tanto, la evaluación motora objetiva de la ES permite estimar de manera automática un score por cada movimiento de la EFM y un score global para todos los movimientos. 4.Interpretación del score global objetivo. Se realiza un análisis granular de los scores estimados por el algoritmo de evaluación, que permite la interpretación de la función motora de la ES de los pacientes con DCA. La interpretación se realiza con un nivel de detalle superior al disponible usando solo retroalimentación visual.Los resultados obtenidos han permitido alcanzar los objetivos planteados en la Tesis. Los métodos de evaluación motora objetiva de la ES en pacientes con DCA permiten mejorar los modelos actuales de neurorrehabilitación motora. Por tanto, los métodos propuestos pueden aumentar la precisión del diagnóstico y lograr una rehabilitación física más personalizada, basada en la evidencia y potencialmente efectiva de los pacientes con DCA. AbstractThe acquired brain injury (ABI) is an alteration of neuronal activity in areas of the brain that occurs after birth. The sequels after an episode of ABI can be motor, cognitive, social, among others, which can transform lives of patients in the educational, work and family environments. ABI can be caused by a traumatic or nontraumatic injury. The most common ABIs are cerebrovascular disease (stroke) and traumatic brain injury (TBI). Stroke is the second most common cause of death and is a major cause of long-term disability worldwide. The World Health Organization estimates that by the year 2020 the TBI will overtake many diseases to take the lead as the main cause of disability.The main objectives of physical neurorehabilitation are to restore and to compensate deficits to achieve maximum functional capacity, facilitating independence and reintegration in the family and social environments. Neurorehabilitation is a complex clinical process aimed at restoring, minimizing and/or compensating the alterations, physical and cognitive, in people with disabilities because of a nervous system injury. Neurorehabilitation is the main alternative, to reduce the impact of deficits derived from brain injuries. In ...

show abstract

Using clinical and robotic assessment tools to examine the feasibility of pairing tDCS with upper extremity physical therapy in patients with stroke and TBI: A consideration-of-concept pilot study

Cited by 38 publications

References 48 publications

Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence

Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence

The contribution of interindividual factors to variability of response in transcranial direct current stimulation studies

Métodos para la evaluación motora objetiva de pacientes con daño cerebral adquirido en neurorrehabilitación funcional

Contact Info

Product

Resources

About